Search Criteria: Research Area is "Mouse/Human Gene Homologs: hypohidrotic ectodermal dysplasia"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 001809 | B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J | Repository- Live |
| Testicular feminization (ArTfm) is a dominant spontaneous mutation on the X chromosome. Hemizygous male mice are outwardly female in appearance except that the vagina does not open until 3 months of age if at all. Male reproductive development is abnormal leading to very small testes, and the absense of vas deferens, the epididymis, and male accessory glands. Spermatogonia and Sertoli cells are present in the testes, but spermatogenesis does not proceed past meiotic prophase. Leydig cells, which normally produce androgen in males, fail to develop normally. This strain is also segregating for the tabby 6J mutation (EdaTa-6J) that affects both the coat color and hair pattern growth. The tabby mutation is maintained in repulsion with the testicular feminization mutation and is used as a coat color marker to assist in identifying resulting genotypes obtained from matings. | ||
| 000314 | B6CBACa Aw-J/A-EdaTa/J-XO | Repository- Live |
| XO or monsomy X mice lack a second sex chromosome. The condition is inherited as an X-linked dominant trait with male lethality. XO mice exhibit some degree of growth retardation, high frequency hearing loss, reduced thyroid activity, reduced body temperature and some behavioral abnormalities. Unlike Turner Syndrome in humans, XO females are fertile. The two-step mating system for this strain (described under Mating System) incorporates the X-linked coat color marker tabby so that mice can be identified by a combination of coat color and sex. This strain may be useful for studies of Turner Syndrome or X-linked recessive alleles. | ||
| 002016 | B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ | Repository-Cryopreserved |
| 000552 | B6-Aw-J-EdaTa-6J.Cg-Sxr | Repository-Cryopreserved |
| 001730 | B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J | Repository-Cryopreserved |
| 000841 | B6-Aw-J.CBy-EdaTa-By/J | Repository-Cryopreserved |
| 000207 | B6C3Fe a/a-Edaraddcr/J | Repository-Cryopreserved |
| 000287 | B6CBACa Aw-J/A-Plp1jp EdaTa/J | Repository-Cryopreserved |
| Hemizygous males carrying the X-linked jimpy spontaneous mutation (Plp1jp) appear normal when sitting quietly, but beginning at about 3 weeks of age they show a marked tremor of the hindquarters when attempting movement. After 3 weeks of age convulsions may occur. These males die between 20 and 40 days of age. In males, the CNS is very deficient in myelin, but the PNS is normally myelinated. Heterozygous jimpy females have normal lifespans with no overt phenotype. However, jimpy heterozygous females are reported to have reduced numbers of oligodendrocytes compared to wildtype females. The stock is also carrying the X-linked tabby mutation (EdaTa). | ||
| 001232 | C3H/HeJ-EdaTa-5J/J | Repository-Cryopreserved |
| 000338 | C57BL/6J Aw-J-EdaTa-6J/J | Repository-Cryopreserved |
| 000569 | C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J | Repository-Cryopreserved |
| Testicular feminization (ArTfm) is a dominant spontaneous mutation on the X chromosome. Hemizygous male mice are outwardly female in appearance except that the vagina does not open until 3 months of age if at all. Male reproductive development is abnormal leading to very small testes, and the absense of vas deferens, the epididymis, and male accessory glands. Spermatogonia and Sertoli cells are present in the testes, but spermatogenesis does not proceed past meiotic prophase. Leydig cells, which normally produce androgen in males, fail to develop normally. This strain is also segregating for the tabby mutation (EdaTa) that affects both the coat color and hair pattern growth. The tabby mutation is maintained in repulsion with the testicular feminization mutation and is used as a coat color marker to assist in identifying resulting genotypes obtained from matings. | ||
| 003112 | STOCK EdaTa-5J/J | Repository-Cryopreserved |
| 000583 | STOCK T(X;16)16H +/+ EdaTa | Repository-Cryopreserved |
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