Search Criteria: Research Area is "Mouse/Human Gene Homologs: immunodeficiency with hyper-IgM, type I (hyper-IgM syndrome)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 002770 | B6.129S2-Cd40lgtm1Imx/J | Repository- Live |
| Mice homozygous for the targeted mutation are viable and fertile. Homozygous mutant mice show no overt phenotypic abnormalities. Percentages of B and T cell subpopulations is normal. Homozygotes do show selective deficiencies in humoral immunity (low basal serum isotype levels and undetectable IgE) as well as abnormal secondary antigen-specific responses to immunization with a thymus-dependent antigen. The phenotype of the mice resembles human X-linked hyper IgM syndrome. | ||
| 002428 | B6;129S2-Cd40lgtm1Imx/J | Repository-Cryopreserved |
| Mice homozygous for the targeted mutation are viable and fertile. Homozygous mutant mice show no overt phenotypic abnormalities. Percentages of B and T cell subpopulations is normal. Homozygotes do show selective deficiencies in humoral immunity (low basal serum isotype levels and undetectable IgE) as well as abnormal secondary antigen-specific responses to immunization with a thymus-dependent antigen. The phenotype of the mice resembles human X-linked hyper IgM syndrome. | ||
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