Search Criteria: Research Area is "Mouse/Human Gene Homologs: leukocyte adhesion deficiency, type I"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 002128 | B6.129S7-Itgb2tm1Bay/J | Repository- Live |
| Mice homozygous for the Itgb2tm1Bay mutation are viable and fertile. Homozygous mutant mice show an increased neutrophil count, and a decreased inflammatory response to peritonitis. Responses to delayed-type hypersensitivity and rejection of transplanted tissue are impaired. PLEASE NOTE: The Itgb2tm1Bay allele is not a null mutation; it is a hypomorphic mutation which results in the expression of very low levels of Itgb2 protein. This strain serves as a model for the moderate form of human CD18 deficiency. | ||
| 006112 | B6.129X1-Ela2tm1Sds/J | Repository- Live |
| Homozygous mice are viable, fertile and phenotypically normal in the absence of inflammatory stress. Homozygotes do not express the targeted gene in bone marrow myeloid cells. Homozygous mice have increased susceptibility to sepsis, morbidity, and mortality following intraperitoneal injection of Gram-negative (e.g. (K. pneumoniae and E. coli), but not Gram-positive (e.g. (S. aureus), bacteria. Despite this, mutant mice are not at increased risk to spontaneous infection. Although neutrophil, T cell, and macrophage migration/recruitment to the site of infection is unaffected in homozygous mutant mice, neutrophils show impaired bactericidal activity. Further, homozygous mice treated with a broad-spectrum inflammatory stimulus (zymosan) have impaired leukocyte firm adhesion and transmigration as well as reduced pro-inflammatory cytokine production. Upon exposure to cigarette smoke, homozygous mice are protected from the accumulation of neutrophils and macrophages in th
..... For more information please see the full descriiption on the strain data sheet | ||
| 003329 | B6.129S7-Itgb2tm2Bay/J | Repository-Cryopreserved |
| Mice homozygous for the Itgb2tm2Bay targeted mutation are viable and fertile, though not good breeders. This mutation differs from the Itgb2tm1Bay mutation (Stock No. 2128) in that it is a null mutation for the Itgb2 subunit of leukocyte integrins. Mutant mice develop chronic dermatitis with extensive facial and submandibular erosions. They also exhibit elevated neutrophil counts, increased immunoglobulin levels, lymphadenopathy, splenomegaly, and abundant plasma cells in skin, lymph nodes, gut and kidney. A severe defect in T cell proliferation can be found in mutant mice when T cell receptors are stimulated either by staphylococcal enterotoxin A or by major histocompatibility complex alloantigens. The phenotype of the mutant mice resembles the phenotype for the human disorder Leukocyte Adhesion Deficiency Type I (LADI). | ||
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