Search Criteria: Research Area is "Mouse/Human Gene Homologs: osteogenesis imperfecta congenita, Ehlers-Danlos syndrome, type VII, autosomal dominant"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 001815 | B6C3Fe a/a-Col1a2oim/J | Repository- Live |
| 006238 | B6;129S4-Thbs2tm1Bst/J | Cryopreserved - Ready for recovery |
| Mice homozygous for this targeted mutation are viable and fertile. Multiple analyses has confirmed the absence of protein in embryonic and adult tissue of homozygous mice. Homozygotes exhibit skin disorders (abnormal collagen fiber patterns, reduced tensile strength, increased fragility) and skin fibroblasts have attachment defects. Mice also exhibit an increase in total density/cortical thickness of the long bones, abnormally long bleeding times, and a significant increase in blood vessel density. Homozygous mice exhibit accelerated wound healing after biopsy and accelerated/increased tumor formation following chemically-induced skin carcinogenesis. Mutant mice may be useful in studies of collagen fibrillogenesis in skin and tendons, angiogenesis and vascular pathophysiology, wound healing, chemically-induced tumor progression, and as a potential model for Ehlers Danlos syndrome. In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are fre ..... | ||
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