Search Criteria: Research Area is "Mouse/Human Gene Homologs: severe combined immunodeficiency disease, autosomal recessive, T-negative/ B-positive type"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 002852 | B6;129S4-Jak3tm1Ljb/J | Repository- Live |
| Mice homozygous for the Jak3tm1Ljb mutation are viable and fertile. B cell development is blocked at pre-B resulting in a significant decrease in peripheral IgM+ B cells. The thymus is small but T cell development is relatively normal. There are increased numbers of CD4+ Cd8- cells in some homozygotes. Proliferative responses to mitogenic signals are defective and Il2 receptor signaling is blocked. The overall phenotype results in a severely immunocompromised mouse. | ||
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