Search Criteria: Research Area is "Metabolism Research: Iron Metabolism"
| Stock Number |
Strain Name Phenotype |
Standard Supply |
| 003333 | C57BL/6-Tg(TF-CAT)48Gsa/J | Repository-Cryopreserved |
| Transferrin is regulated by iron at the level of translation. This transgenic strain carries a chimeric gene composed of the human TF 5'-flanking sequences fused to the CAT reporter gene. Iron administration to transgenic mice results in a significant decrease of transferrin-directed CAT enzyme activity and CAT protein in the liver. This strain is useful for understanding the expression of the human TF gene and its age-related regulation. During aging, expression of the transgene decreases in the liver, but not in the brain, and liver expression is suppressed by iron and lipopolysaccharide. | ||
| 003582 | STOCK Cptm1Hrs/J | Repository-Cryopreserved |
| Mice that are homozygous null for the Cp gene demonstrate a progressive accumulation of iron in hepatocytes and reticuloendothelial cells. By one year of age, iron content of the liver and spleen reaches three to six-fold that observed in wild-type litter mates. The Cp gene product appears to be necessary for proper iron efflux from these cell types. This strain represents a viable murine model for aceruloplasminemia. At one year of age there is no evidence of anemia, diabetes, or neurological symptoms despite iron accumulation at the corresponding tissue sites. | ||
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