Search Criteria: Research Area is "Research Tools: Genetics Research (Mutagenesis and Transgenesis)"

JAX^® Mice Strains

Stock Number	Strain Name   Strain Description	Standard Supply
003462	B6.129S1-Thrbtm1Df/J	Repository-Cryopreserved
	Mice homozygous for the Thrbtm1Df targeted mutation are viable and fertile displaying normal growth rates. Homozygous mutant mice exhibit goiter and elevated levels of both thyroid hormone and thyroid stimulating hormone. Defects in liver responses to thyroid hormone and subtle behavioral abnormalities are observed. The mice fail to develop normal hearing, as assessed by impaired auditory-evoked brainstem responses, and are susceptible to audiogenic seizures. This strain provides a recessive model for the human syndrome of generalized thyroid hormone resistance (GTHR).

(1 stocks)         Back to Top

Send questions to our Technical Support team using the Express Technical Support Form.
(3.2)