Search Criteria: Research Area is "Mouse/Human Gene Homologs: Wiskott-Aldrich syndrome"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 003292 | 129S6/SvEvTac-Wastm1Sbs/J | Cryopreserved - Ready for recovery |
| WAS-deficient mice are viable and fertile. Mutant mice show normal lymphocyte development, serum immunoglobulin (Ig) levels and antibody responses. However, peripheral blood lymphocyte counts and platelet numbers are reduced in these mice. Development of chronic colitis is also observed. In vitro, WAS-deficient T cells show markedly impaired proliferative responses to anti-CD3e mediated stimulation. The Was gene is X-linked, so hemizygous males are WAS deficient. | ||
| 002498 | B6;129S4-Spntm1Bam/J | Cryopreserved - Ready for recovery |
| Mice homozygous for the Spntm1Bam mutation are viable and fertile. Homozygous mutant mice have normal numbers of T-cells, however, there is increased proliferation over controls in response to various T-cell activators. Adhesion is increased. Mice may be used as a model for Wiskott-Aldrich Syndrome, an X-linked combined T- and B-cell deficiency characterized by eczema and thrombocytopenia, and recurrent infection. Also known as CD43 and leukosialin. | ||
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