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New Strains Awaiting Transfer from the Donor
Additional Register Interest Strains

JAX® Mice Strains

Stock
Number
Strain Name
 
Strain Description
Standard Supply
007850 J:NU
Level 1
Outbred homozygous nude (Foxn1nu/Foxn1nu) mice are the standard in vivo model for drug efficacy testing in oncology. Nude mice are athymic and hairless as a result of the recessive nu mutation. T cell precursors exist but development is blocked in the absence of a thymus, resulting in an immunodeficiency that permits transplantation of tumor cell xenografts. Homozygous females are poor breeders and fail to lactate. Heterozygous males and females breed well and have normal immune function. Homozygous pups can be identified as young as 24 hours by their lack of whiskers or poorly developed, crinkled whiskers.
002019 NU/J
Level 2
The two main defects of mice homozygous for the nude spontaneous mutation (Foxn1nu, formerly Hfh11nu) are abnormal hair growth and defective development of the thymic epithelium. Although the mice appear hairless, they are born with functional but faulty hair growth follicles. Hair growth cycles and patterns are evident especially in pigmented mice but the faulty follicles do not allow the hair to properly erupt. Homozygous pups can be identified as young as 24 hours by their lack of whiskers or poorly developed, crinkled whiskers. Nude mice are also athymic caused by a developmental failure of the thymic anlage. Consequently, homozygous nude mice lack T cells and suffer from a lack of cell-mediated immunity. However there is not a defect in T-cell precursors, and under the right conditions some functional mature T cells can be found especially in adult mice. Because of a defect in helper T-cell activity, responses to thymus-dependent antigens when d .....
For more information please see the full phenotype on the strain data sheet
007799 NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ
Level 3
These NRG mice are NOD-congenic mice harboring the Rag1null mutation (Rag1KO or Rag1tm1Mom) on chromosome 2 and the IL2rγnull mutation (IL2RγcKO or Il2rgtm1Wjl) on the X chromosome. These NRG mutant mice are also called NOD-Rag1null IL2rγnull double mutant mice or NOD.Rag1KO.IL2RγcKO mice. Females homozygous for both mutations (and males homozygous for Rag1null; hemizygous for the X-linked IL2rγnull mutation) are viable and fertile. When compared to NOD-scid IL2rgnull mice (NSG mice; Stock No. 005557), these NRG mice tolerate much higher levels of irradiation conditioning. Additionally, NRG mice support higher levels of both human cord blood stem cell engraftment following irradiation-conditioning (leading to multi-lineage hematopoietic cel .....
For more information please see the full phenotype on the strain data sheet
000819 B6.Cg-Foxn1nu/J
Level 4
The two main defects of mice homozygous for the nude spontaneous mutation (Foxn1nu, formerly Hfh11nu) are abnormal hair growth and defective development of the thymic epithelium. Although the mice appear hairless, they are born with functional but faulty hair growth follicles. Hair growth cycles and patterns are evident especially in pigmented mice but the faulty follicles do not allow the hair to properly erupt. Homozygous pups can be identified as young as 24 hours by their lack of whiskers or poorly developed, crinkled whiskers. Nude mice are also athymic caused by a developmental failure of the thymic anlage. Consequently, homozygous nude mice lack T cells and suffer from a lack of cell-mediated immunity. However there is not a defect in T-cell precursors, and under the right conditions some functional mature T cells can be found especially in adult mice. Because of a defect in helper T-cell activity, responses to thymus-dependent antigens when .....
For more information please see the full phenotype on the strain data sheet
017700 B6.129-Rag1tm1Mom Fcgrttm1Dcr/DcrJ
Repository- Live
The neonatal Fc receptor, encoded by the Fcgrt gene, is a MHC class I like molecule. One of its functions is to protect IgG and albumin from degradation, and to mediate the transport of IgG across epithelial cells. Further, it plays a role in antigen presentation by professional antigen presenting cells. It has been demonstrated that FcRn is critical for the materno-fetal transport and intestinal uptake of IgG. Mice that are homozygous for the FcRn α-chain and Rag1 knockout mutations are viable and fertile. Homozygotes exhibit a low plasma albumin concentration due to the lack of murine FcRn (see strain description Stock No. 003982) and lack mature B- and T-cells caused by the Rag1 knockout (see strain description Stock No. 002216). It is possible to perform xenograft studies in these mice and to study the involvement of the FcRn pathway in resp .....
For more information please see the full phenotype on the strain data sheet
008451 B6.129P(Cg)-Ptprca Cx3cr1tm1Litt/LittJ
Repository- Live
Mice that are homozygous for the CX3CR1-GFP targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. RT-PCR analysis of lymphoid tissue from homozygotes detects mutant gene product (mRNA) and no wild type gene product (mRNA). Flow cytometric analysis of peripheral blood cells identified a subset of green fluorescent cells not observed in wild type mice. Enhanced Green Fluorescent Protein (EGFP), but not the endogenous gene, is expressed in monocytes, dendritic cells, NK cells, and brain microglia, mimicking endogenous gene expression. The same subset of peripheral blood cells isolated from heterozygote mice express detectable levels of EGFP. Immunohistochemical analysis of spleen and peripheral nerve tissue from homozygotes does not detect EGFP. These mice also express the CD45.1 (Ly5.1 or Ptprca) allele, which is atypical for the C57BL/6 congenic background, and this marker may be used to track donor cell popul .....
For more information please see the full phenotype on the strain data sheet
005582 B6.129P-Cx3cr1tm1Litt/J
Repository- Live
Mice that are homozygous for the CX3CR1-GFP targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. RT-PCR analysis of lymphoid tissue from homozygotes detects mutant gene product (mRNA) and no wild type gene product (mRNA). Flow cytometric analysis of peripheral blood cells identified a subset of green fluorescent cells not observed in wild type mice. Enhanced Green Fluorescent Protein (EGFP), but not the endogenous gene, is expressed in monocytes, dendritic cells, NK cells, and brain microglia, mimicking endogenous gene expression. The same subset of peripheral blood cells isolated from heterozygote mice express detectable levels of EGFP. Immunohistochemical analysis of spleen and peripheral nerve tissue from homozygotes does not detect EGFP. These CX3CR1-GFP mutant mice may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies.

Of note, CX3CR1-GFP mice are also avail .....
For more information please see the full phenotype on the strain data sheet

013115 B6.Cg-Rag1tm1Mom Tg(UBC-GFP)30Scha/J
Repository- Live
Rag1-deficient ubiquitin-GFP mice on the C57BL/6 genetic background (B6.Rag1-/-;UBC-GFP) combine lymphocyte-deficiency with widespread green fluorescent protein expression. Mice homozygous for both the Rag1 null allele and the UBC-GFP transgene (Rag1-/-;UBC-GFP+/+) are viable and fertile. Double homozygous mice produce no mature T cells or B cells, and have widespread GFP expression that is uniform within cell lineage. GFP expression varies between different cell types; hematopoetic cells have high expression levels compared with other cells. Red blood cells from UBC-GFP homozygotes should fluoresce at approximately twice the level compared to UBC-GFP hemizygotes.

Similar to other immunodeficient strains, maintaining Rag1-deficient mice in high health status (specific pathogen-free) vivaria promotes overall colony health. If Rag1-deficient animals are maintained in low health barrier rooms, the use of medicated water (sulf .....
For more information please see the full phenotype on the strain data sheet

017840 B6.Cg-Tyrc-2J Hrhr/J
Repository- Live
These B6.albino;hairless mice are a C57BL/6-congenic line harboring both the albino allele (Tyrc-2J) and hairless allele (Hrhr). The lack of skin pigmentation and hair allow studying ultraviolet light-induced carcinogenesis.

C57BL/6J-congenic albino mice are described and available from The Jackson Laboratory as Stock No. 000058.

C57BL/6J-congenic hairless mice are described and available from The Jackson Laboratory as Stock No. 001737. Females homozygous for the hairless mutation may become pregnant, but have poor lactation and fail to keep their pups warm; resulting in death of their litters.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted tha .....
For more information please see the full phenotype on the strain data sheet

007897 B6.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
Repository- Live
Mice hemizygous for this ROSA26-EGFP BAC transgene are viable and fertile, with widespread EGFP expression in all organs and tissues analyzed. In addition, stable and uniform EGFP expression is observed in differentiated progeny of transplanted hematopoietic stem cells (HSC) isolated from ROSA26-EGFP mice. These ROSA26-EGFP BAC transgenic mice may be useful for fluorescent labeling of cells and tissues both in vivo and in vitro, are suitable for use in histological preparations, and are appropriate as a source of fluorescently labeled donor cell populations (such as tracking hematopoietic cell fate in transplant recipients).

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as publis .....
For more information please see the full phenotype on the strain data sheet

004191 B6.Cg-Tg(HLA-A/H2-D)2Enge/J
Repository- Live
These transgenic mice express an interspecies hybrid class I MHC gene, AAD, which contains the alpha-1 and alpha-2 domains of the human HLA-A2.1 gene and the alpha-3 transmembrane and cytoplasmic domains of the mouse H-2Dd gene, under the direction of the human HLA-A2.1 promoter. Immunodetection of the HLA-A2.1 recombinant transgene established that expression was at equivalent levels to endogenous mouse class I molecules. The mouse alpha-3 domain expression enhances the immune response in this system. Compared to unmodified HLA-A2.1, the chimeric HLA-A2.1/H2-Dd MHC Class I molecule mediates efficient positive selection of mouse T cells to provide a more complete T cell repertoire capable of recognizing peptides presented by HLA-A2.1 Class I molecules. The peptide epitopes presented and recognized by mouse T cells in the context of the HLA-A2.1/H2-Dd class I molecule are the same as those presented in HLA-A2.1+ humans. Mice homozygous for the .....
For more information please see the full phenotype on the strain data sheet
004509 B6.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
Repository- Live
Mice that are homozygous for the transgene are viable, normal in size and do not display any gross physical or behavioral abnormalities. Upon diphtheria toxin (DT) administration, mice harboring this transgene are transiently depleted of dendritic cell (DC) populations. All CD8+ and CD8- DC in the spleen express EGFP and are DT sensitive. Immunohistochemical and flow cytometric analysis reveals EGFP expression and DT-inducible depletion of CD11chigh DC in spleen, lymph node, lung, liver and lamina propria tissues, as well as the defined macrophage subpopulations of the alveolar, lamina propria, metallophillic and marginal zone. Rapid reduction of CD11c+ DC populations induced by intraperitoneal injection of DT persists for approximately 2 days, after which the cell population gradually recovers. While transient DC depletion was not associated with sign of illness or long-term defects, repeated DT induction is lethal to the mouse. Long term de .....
For more information please see the full phenotype on the strain data sheet
011070 B6;CBA-Tg(Thy1-EGFP)SJrs/NdivJ
Repository- Live
Mice harboring the Thy1-GFP transgene are viable and fertile with enhanced green fluorescent protein (EGFP) expression under the control of a modified Thy1 promoter region (containing the sequences required for neuronal expression but lacking the sequences required for expression in non-neural cells). These thy1-GFP-S mice (derived from founder line S) have EGFP expression in sparse subsets of neurons within specific populations; providing a bright, vital Golgi-like stain. Thy1-GFP-S mice show EGFP labeling in the superficial layers of the neocortex, including most/all interneuron subtypes, with pyramidal/interneuron ratios of approximately 4:1 that match the distribution in the non-labeled population. While this is similar to Thy1-GFPM mice (Stock No. 007788), the labeling distribution for line S is different from line M. In addition, less than 10% of cerebellum mossy fibers show EGFP labeling and no EGFP expressio .....
For more information please see the full phenotype on the strain data sheet
012873 C.DDD-plt/NknoJ
Repository- Live
Homozygous BALB/c-plt mice are viable and fertile, harboring the spontaneous plt (or "paucity of lymph node T cells") deletion of both the Ccl19 and Ccl21a loci on chromosome 4. Lack of expression of these two CCR7 receptor ligands in the secondary lymphoid organs results in abnormal leukocyte migration and impaired immune response. Specifically, homozygous mice have disrupted trafficking/homing of T cells and dendritic cells to lymphoid tissues. No reported abnormalities in B cell distribution/cellularity are reported for homozygous mice. Homozygous mice exhibit mature single-positive thymocyte arrest in the thymic cortex that results in defective formation of the medullary region of the thymus. Thymic export of T cells in these mice is compromised during the neonatal period but not in adulthood. While CCL21 expression is absent in lymphoid organs because of the Ccl21a deletion, CCL21 expression in non-lymphoid organs is observed because the upstre .....
For more information please see the full phenotype on the strain data sheet
010545 C.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
Repository- Live
These L2G85.BALB/c mice harbor the CAG-luc-eGFP L2G85 transgene. Homozygous mice are viable and fertile, with widespread expression of firefly luciferase and enhanced green fluorescent protein directed by the CAG promoter (human cytomegalovirus immediate early promoter enhancer with chicken beta-actin/rabbit beta-globin hybrid promoter). Bioluminesence is detected in heart, spleen, muscle, pancreas, skin, thymus and bone marrow. Luciferase activity is not detected in mature erythrocytes, although low levels are detected in erythrocyte precursors and varying levels of activity in all leukocyte subsets tested. Homozygotes have no reported gross physical or behavioral abnormalities. Following luciferin injection, luciferase expression is generally greater in males than females. GFP fluorescence is detected in skin (upper epidermal layers) by fluorescence microscopy. The Donating Investigator reports that for the FVB-Tg(CAG-luc,-GFP)L2G85Chco/J (STOCK#8450) strain, no GFP fluorescence .....
For more information please see the full phenotype on the strain data sheet
004512 C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
Repository- Live
Mice that are homozygous for the transgene are viable, normal in size and do not display any gross physical or behavioral abnormalities. Upon diphtheria toxin (DT) administration, mice harboring this transgene are transiently depleted of dendritic cell (DC) populations. All CD8+ and CD8- DC in the spleen express EGFP and are DT sensitive. Immunohistochemical and flow cytometric analysis reveals EGFP expression and DT-inducible depletion of CD11chigh DC in spleen, lymph node, lung, liver and lamina propria tissues, as well as the defined macrophage subpopulations of the alveolar, lamina propria, metallophillic and marginal zone. Rapid reduction of CD11c+ DC populations induced by intraperitoneal injection of DT persists for approximately 2 days, after which the cell population gradually recovers. While transient DC depletion was not associated with sign of illness or long-term defects, repeated DT induction is lethal to the mouse. Long term de .....
For more information please see the full phenotype on the strain data sheet
008450 FVB-Tg(CAG-luc,-GFP)L2G85Chco/J
Repository- Live
Mice homozygous for the CAG-luc-eGFP L2G85 transgene are viable and fertile, with widespread expression of firefly luciferase and enhanced green fluorescence protein directed by the CAG promoter (human cytomegalovirus immediate early promoter enhancer with chicken beta-actin/rabbit beta-globin hybrid promoter). Bioluminesence is detected in heart, spleen, muscle, pancreas, skin, thymus and bone marrow. Luciferase activity is not detected in mature erythrocytes, although low levels are detected in erythrocyte precursors and varying levels of activity in all leukocyte subsets tested. Homozygotes have no reported gross physical or behavioral abnormalities. Following luciferin injection, luciferase expression is generally greater in males than females. GFP fluorescence is detected in skin (upper epidermal layers) by fluorescence microscopy. The Donating Investigator reports that for the FVB-Tg(CAG-luc,-GFP)L2G85Chco/J (STOCK#8450) strain, no GFP fluorescence is detected in hematopoiet .....
For more information please see the full phenotype on the strain data sheet
021885 NOD.Cg-Prkdcscid H2-Ab1tm1Gru Il2rgtm1Wjl/SzJ
Repository- Live
NSG-Abo mice are NOD.scid.Il2Rγcnull ("NSG"; Stock No. 005557) animals also harboring the H2-Ab1tm1Gru knockout allele (Abo). NSG-Abo females homozygous for all three mutations, and males homozygous for scid, homozygous for Abo and hemizygous for the X-linked Il2Rγcnull may be collectively referred to as homozygous NSG-Abo mice.

Although viable and fertile, homozygous NSG-Abo mice are immunodeficient: they have no mature T cells or B cells, lack functional natural killer (NK) cells, are deficient in cytokine signaling, and do not express murine major histocompatibility complex (MHC) class II (lack cell surface expression of both class II-A and class II-E MHC proteins). While both homozygous NSG and homozygous NSG-Abo mice readily allow engraftment of purified human CD4> .....
For more information please see the full phenotype on the strain data sheet

017914 NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(HLA-DRA,HLA-DRB1*0401)39-2Kito/ScasJ
Repository- Live
DRAG mice are NOD.Rag1KO.IL2RγcKO ("NRG"; Stock No. 007799) animals with chimeric human-mouse class II transgenes encoding the HLA class II antigen binding domain molecules (defined by the HLA-DR4 genotype [HLA-DRA/HLA-DRB1*0401]) fused to the I-Ed MHC class II molecule. The presence of these HLA-DR4-IE transgenes allows irradiated DRAG mice to be engrafted with HLA-DR-matched hematopoietic stem cells (HSC); resulting in humanized T cell and B cell populations.

DRAG females homozygous for both mutations and homozygous for the co-injected transgenes (and DRAG males homozygous for the Rag1KO mutation; hemizygous for the X-linked IL2RγcKO mutation; homozygous for the co-injected transgenes) are viable and fertile, with no mature T cells, B cells, or natural killer (NK) cells. Like NRG mice, DRAG mice have the same irradiation/engraftment advantages compared to NOD.scidKO.IL2RγcKO ("NSG"; Sto .....
For more information please see the full phenotype on the strain data sheet

014543 STOCK Hgftm1.1(HGF)Aveo Prkdcscid/J
Repository- Live
Mice homozygous for both the hHGFki and Prkdcscid alleles, also called immunocompromised hHGFki mice, are viable and fertile.

The hHGFki allele is a "humanized" knock-in mutation that replaces the mouse hepatocyte growth factor (HGF) coding region downstream of the signal sequence with the human HGF cDNA sequence. As a result, the endogenous mouse promoter drives expression of human HGF. While the human HGF activates both the human and murine form of its tyrosine kinase receptor (met proto-oncogene (MET; c-Met)), the murine HGF is unable to activate human MET. Mice homozygous for hHGFki express only the human form of HGF. In homozygous hHGFki mice, HGF expression from the knock-in allele is observed in developing embryo, as well as adult liver, kidney and lung. hHGFki homozygous mice exhibit an increase in serum HGF after clotting.

Mice homozygous for the Prkdcscid mutation exhibit T- and B-cell deficiency.

007788 STOCK Tg(Thy1-EGFP)MJrs/J
Repository- Live
Mice harboring the Thy1-GFP transgene are viable and fertile with enhanced green fluorescent protein (EGFP) expression under the control of a modified Thy1 promoter region (containing the sequences required for neuronal expression but lacking the sequences required for expression in non-neural cells). Homozygous or hemizygous Thy1-GFP mice derived from founder line M (Thy1-GFP-M or Thy1-GFPM) express EGFP in sparse subsets of neurons within specific populations; providing a bright, vital Golgi-like stain. Less than 10% of all motor axons, retinal ganglion cells, lumbar dorsal root ganglion, and cortex express EGFP. These Thy1-GFPM transgenic mice may be useful in neurobiological studies for fluorescent labeling of neural tissues, especially for mossy fibers in the cerebellum and intense, yet sparse, labeling of a variety of neuronal subsets.

This strain is one of many from the donating investigator with specific/differential fluorescent protein expression in neural tissues (see .....
For more information please see the full phenotype on the strain data sheet

021571 BXSB.129S7(B6)-Rag1tm1Mom/DcrJ
Under Development - Now Accepting Orders
Rag1-deficient BXSB.Yaa mice (BXSB.Rag1-/- or BXSB.Yaa Rag1-/-) are a BXSB/MpJ-congenic strain carrying a null mutation of the recombination activating gene 1.

BXSB/MpJ inbred males (Stock No. 000740) develop a spontaneous lupus-like autoimmune syndrome: mortality starts at ~13 weeks of age with 50% lethality by ~30 weeks and 76% lethality by ~40 weeks. BXSB/MpJ inbred females develop a greatly attenuated form of autoimmune disease because they lack Yaa.

Homozygous (Rag1-/-) mice are viable and fertile. Homozygotes produce no mature T cells or B cells, and should be maintained in pathogen-free conditions on sulfatrim water to increase colony health (similar to other immunodeficient strains). Compared to BXSB/MpJ, the lymphocyte-deficiency of BXSB.Rag1-/- mice prevents manifestation of the spontaneous autoimmune phenotype in both males and females.

Heterozygous males (BXSB.Rag1+/-) develop the BXSB .....
For more information please see the full phenotype on the strain data sheet

023848 NOD.Cg-Prkdcscid H2-K1tm1Bpe H2-D1tm1Bpe Il2rgtm1Wjl/SzJ
Under Development - Now Accepting Orders
NSG-(KbDb)null mice are NOD.scid.Il2Rγcnull ("NSG"; Stock No. 005557) animals also harboring knockout alleles of the MHC class I genes (Kb null and Db null). NSG-(KbDb)null females homozygous for all three mutations, and males homozygous for scid, homozygous for Kb null, homozygous for Db null and hemizygous for the X-linked Il2Rγcnull may be collectively referred to as homozygous NSG-(KbDb)null mice.

Although viable and fertile, homozygous NSG-(KbDb)null mice are immunodeficient: they have no mature T cells or B cells, lack functional natural killer (NK) cells, are deficient in cytokine signaling, and do not express murine major histocompatibility complex (MHC) class I molecules (lack c .....
For more information please see the full phenotype on the strain data sheet

024099 NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/J
Under Development - Now Accepting Orders
NRGS (NRG-SGM3) mice are NOD.Rag1-;γcnull (NRG) animals also carrying the SGM3 (3GS) triple coinjected transgenes that express human interleukin-3 (IL-3), human granulocyte/macrophage-stimulating factor (GM-CSF) and human Steel factor (SF).

NRGS females homozygous for both mutations and homozygous for the 3GS triple coinjected transgenes (and NRGS males homozygous for the Rag1- mutation, hemizygous for the X-linked ;γcnull mutation and homozygous for the 3GS triple coinjected transgenes) are viable and fertile, with no mature T cells, B cells, or natural killer (NK) cells. Like NOD.Rag1-/-;γcnull mice (NRG; Stock No. 007799), these NRGS mice have the same irradiation/engraftment advantages over NOD.scid ;γcnull (NSG; Stock No. 005557) .....
For more information please see the full phenotype on the strain data sheet

016195 B6(SJL)-Foxn1nu-2J/GrsrJ
Cryopreserved - Ready for recovery
Mice homozygous for the nude 2 Jackson mutation can be identified by approximately 1 week of age by their wrinkly skin. Histology of the skin shows severe follicular dystrophy and their hair fails to grow in leaving them hairless throughout their shortened lifespan. Homozygotes are athymic, smaller than normal, and have short, curled, or sparse vibrissae. Females have small litters or fail to produce pups.
006221 B6.129S1-Lyve1tm1Lhua/J
Cryopreserved - Ready for recovery
Homozygotes are viable and fertile, and produce normal-sized litter. No gross phenotypic or behavioral abnormalities have been reported, even in older (2 year old) mice. Homozygous mutants express neither endogenous RNA or protein in liver tissue. Lymphatic capillary vessel morphology in the liver and intestines of homozygous mice is abnormal, with vessels having distended or rounded lumens in contrast to the smaller, typically collapsed, irregular shapes observed in wildtype controls. Intradermal interstitial-lymphatic flow also is increased. Syngenic tumor cell transplants into grow more rapidly and robustly in homozygous mutant mice compared with transplants into wildtype mice, and develop porous interstitial spaces. These mutant mice may be useful in studies of structural and functional characteristics of the lymphatic system, cell-surface retention sequence (CRS) motif-containing growth factor secretion, autocrine and paracrine regulation of cell growth, as well as of cancer and t .....
For more information please see the full phenotype on the strain data sheet
006413 B6.129S6-Erap1tm1Luc/J
Cryopreserved - Ready for recovery
Homozygous mutant mice are viable and fertile. The absence of mRNA in splenocyte and of protein in hepatocyte lysates is confirmed via RT-PCR and immunoblot, respectively. Homozygous mutants display reduced cell surface expression of MHC class Ia and Ib molecules, altered presentation of self- and foreign-antigens, and defective CD8+ T-cell responses against class I-presented antigens. These mutant mice may be useful in immunological studies exploring ERAP1's role in vivo in optimizing peptides for presentation by MHC class I molecules.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

007919 B6.Cg-Tg(Thy1-EGFP)OJrs/GfngJ
Cryopreserved - Ready for recovery
Mice hemizygous for the Thy1-GFP transgene are viable and fertile with enhanced green fluorescent protein (EGFP) expression under the control of a modified Thy1 promoter region (containing the sequences required for neuronal expression but lacking the sequences required for expression in non-neural cells). Thy1-GFP mice derived from founder line O express EGFP in subsets of neurons within specific populations; providing a bright, vital Golgi-like stain. High (>80%) EGFP expression is observed in motor axons and cerebellar mossy fibers. Low (<10%) EGFP expression is observed in retinal ganglion cells and lumbar dorsal root ganglion. Sparse EGFP-labeling is also observed in neurons from multiple cortical layers. These Thy1-GFP line O transgenic mice may be useful for fluorescent labeling of neural tissues; especially motor axons and cerebellar mossy fibers, as well as intense, yet sparse, labeling of a variety of cortical neurons.

This strain is one of many from the same transgene .....
For more information please see the full phenotype on the strain data sheet

010562 B6.Cg-Tg(Wap-ERBB2)229Wzw/J
Cryopreserved - Ready for recovery
Mice that are hemizygous for the transgene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express human ERBB2 (HER2) under the control of the mouse whey acid protein promoter (Wap). The Wap promoter directs expression to the mammary gland and molecular layer of the cerebellum. Mice do not develop spontaneous tumors, but are tolerant to ERBB2 tumor associated antigen, developing tumors after inoculation with ERBB2 expressing tumor cells. Anti-tumor immunity can be induced using aggressive DNA vaccination. This mutant mouse strain may be useful in testing ERBB2-based vaccines and immunotherapies.
010816 B6;C-Ghrhrlit Prkdcscid/BmJ
Cryopreserved - Ready for recovery
B6;C-GhrhrlitPrkdcscid/BmJ mice are deficient in growth hormone and IGF1 and are useful for determining endocrine dependence of grafted cells and tissues (Beamer et al., 1993, Cancer Research, v53:3741; Friend et al., 2001 Growth Hormone & IGF Research, v11:84).
012866 B6N.DDD-plt/NknoJ
Cryopreserved - Ready for recovery
Homozygous C57BL/6-plt mice are viable and fertile, harboring the spontaneous plt (or "paucity of lymph node T cells") deletion of both the Ccl19 and Ccl21a loci on chromosome 4. Lack of expression of these two CCR7 ligands in the secondary lymphoid organs results in abnormal leukocyte migration and impaired immune response. Specifically, homozygous mice have disrupted trafficking/homing of T cells and dendritic cells to lymphoid tissues. No reported abnormalities in B cell distribution/cellularity are reported for homozygous mice. Transient migration of antigen-stimulated B cells in lymphoid organs (which facilitates B cell/helper T cell interactions) is also impaired in homozygous mice. Homozygous mice exhibit mature single-positive thymocyte arrest in the thymic cortex that results in defective formation of the medullary region of the thymus. Thymic export of T cells in these mice is compromised during the neonatal period but not in adulthood. While C .....
For more information please see the full phenotype on the strain data sheet
007848 BXSB.129P2(Cg)-Tcratm1Mjo/TheoJ
Cryopreserved - Ready for recovery
Male mice on the BXSB recombinant inbred genetic background (see Stock No. 000740) develop spontaneous autoimmune disease closely resembling the human disease systemic lupus erythematosus (SLE), including moderate lymph node and spleen enlargement, hemolytic anemia, hypergammaglobulinemia, and immune complex glomerulonephritis. This autoimmune phenotype is associated with at least six non-MHC loci (the Y chromosome linked Yaa, Bxs1-4 on chromosome 1 and Bxs6 on chromosome 13) and defined by increased homeostatic proliferation of self-reactive T cells. Because these BXSB-Tcrα-/- mice are homozygous for the Tcrα targeted mutation, they lack αβ+ T cells and do not develop spontaneous lupus symptoms. These BXSB-Tcrα-/- mice may be useful for adoptive transfer experiments for studying the role of T cells in systemic autoimmunity and lupus.
008337 CBA/Ca-Tg(H2-K-HLA-G,B2M)1Alm/CmwJ
Cryopreserved - Ready for recovery
HLA-G transgenic (HLA-Gtg) mice are viable, fertile, and harbor two co-injected transgenes; H-2Kb/HLA-G and hβ2m. It was found that co-injecting the hβ2m transgene greatly facilitated expression of the whole HLA-G molecule, implying that endogenous mouse β2m cannot substitute for its human homolog. In addition, the CBA/Ca genetic background has a spontaneous deletion of the genes that encode the structurally/functionally homologous mouse Qa-2 protein, thus experimental results obtained using these HLA-Gtg mice may be attributed directly to transgene expression. Expression of HLA-G expression is observed in pre-implantation embryos and a variety of tissues; expression in the reproductive organs (uterus, ovary, and testes), lung, and liver is much more similar to mouse expression of Qa-2 than to Kb (despite the presence of the H-2Kb promoter and downstream coding sequence), while HLA-G expression in spleen, .....
For more information please see the full phenotype on the strain data sheet
007898 CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
Cryopreserved - Ready for recovery
Mice hemizygous for this ROSA26-EGFP BAC transgene are viable and fertile, with widespread EGFP expression in all organs and tissues analyzed. In addition, stable and uniform EGFP expression is observed in differentiated progeny of transplanted hematopoietic stem cells (HSC) isolated from ROSA26-EGFP mice. These ROSA26-EGFP BAC transgenic mice may be useful for fluorescent labeling of cells and tissues both in vivo and in vitro, are suitable for use in histological preparations, and are appropriate as a source of fluorescently labeled donor cell populations (such as tracking hematopoietic cell fate in transplant recipients).

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as publish .....
For more information please see the full phenotype on the strain data sheet

000711 CByJ.Cg-Foxn1nu/J
Cryopreserved - Ready for recovery
The two main defects of mice homozygous for the nude spontaneous mutation (Foxn1nu, formerly Hfh11nu) are abnormal hair growth and defective development of the thymic epithelium. Although the mice appear hairless, they are born with functional but faulty hair growth follicles. Hair growth cycles and patterns are evident especially in pigmented mice but the faulty follicles do not allow the hair to properly erupt. Homozygous pups can be identified as young as 24 hours by their lack of whiskers or poorly developed, crinkled whiskers. Nude mice are also athymic caused by a developmental failure of the thymic anlage. Consequently, homozygous nude mice lack T cells and suffer from a lack of cell-mediated immunity. However there is not a defect in T-cell precursors, and under the right conditions some functional mature T cells can be found especially in adult mice. Because of a defect in helper T-cell activity, responses to thymus-dependent antigens when d .....
For more information please see the full phenotype on the strain data sheet
010548 D1.FVB(Cg)-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
Cryopreserved - Ready for recovery
These L2G85.DBA/1 mice harbor the CAG-luc-eGFP L2G85 transgene. Homozygous mice are viable and fertile, with widespread expression of firefly luciferase and enhanced green fluorescent protein directed by the CAG promoter (human cytomegalovirus immediate early promoter enhancer with chicken beta-actin/rabbit beta-globin hybrid promoter). Bioluminesence is detected in heart, spleen, muscle, pancreas, skin, thymus and bone marrow. Luciferase activity is not detected in mature erythrocytes, although low levels are detected in erythrocyte precursors and varying levels of activity in all leukocyte subsets tested. Homozygotes have no reported gross physical or behavioral abnormalities. Following luciferin injection, luciferase expression is generally greater in males than females. GFP fluorescence is detected in skin (upper epidermal layers) by fluorescence microscopy. The Donating Investigator reports that for the FVB-Tg(CAG-luc,-GFP)L2G85Chco/J (STOCK#8450) strain, no GFP fluorescence .....
For more information please see the full phenotype on the strain data sheet
006125 FVB-Tg(H2-D-Il15)3304Clgr/J
Cryopreserved - Ready for recovery
Mice hemizygous for this transgene are viable and fertile. The transgene was designed to optimize the overexpression of secreted, mature interleukin-15. Transgenic IL-15 expression has a similar tissue distribution as the endogenous gene, but at a significantly higher level. IL-15 protein is detectable in the serum from most mutant, but not from wildtype, mice. Mutant mice develop a progressive alopecia by as early as 5-6 weeks of age, with skin lesions appearing over time. While all transgenic mice exhibit early polyclonal/benign expansion of natural killer and memory CD8+ T lymphocytes (T/NK), two distinct phenotypes emerge over time: approximately 70% of the transgenic mice will exhibit polyclonal T/NK progression in multiple tissues, while the remaining 30% are characterized by T/NK clonal expansion in multiple tissues and acute lymphoblastic leukemia (T/NK ALL). Both T/NK phenotypes are fatal within the first year of life. Mice harboring this transgene may be useful in .....
For more information please see the full phenotype on the strain data sheet
002856 FVB/N-Tg(TIE2-lacZ)182Sato/J
Cryopreserved - Ready for recovery
Transgenic mice carry a beta-galactosidase reporter gene under the control of the murine Tek (Tie2) promoter. LacZ is expressed specifically in vascular endothelial cells in embryonic and adult mice. The transgenic line may be useful when crossed with tumor producing strains and the transgene used to visualize neovascularization during tumorigenesis.
004222 NOD.129P2(B6)-Il4tm1Cgn/DvsJ
Cryopreserved - Ready for recovery
Complete Freund's adjuvant (CFA) induced suppression of diabetes in NOD mice has been associated with a shift to Th2 cytokine production. NOD mice deficient in IL4 were created to investigate the role of IL4 in this shift. Mice homozygous for the Il4tm1Cgn targeted mutation are viable and fertile. T and B cell development is normal but IgG1and IgE levels and the ability of homozygous mutant mice to produce Th2-derived cytokines are significantly reduced. IL4 deficient NOD mice develop IDDM with the same incidence as standard NOD/Lt controls, and there is no change between IL4 deficient and wildtype NOD in disease protection conferred by treatment of bacillus Calmette-Guerin vaccine (BCG) or CFA. Both IL4 deficient and wildtype NOD mice are significantly protected from insulitis by treatment of CFA but not by treatment of BCG. (Serreze et al 2001)
004266 NOD.Cg-Il10tm1Cgn/DvsJ
Cryopreserved - Ready for recovery
Mice homozygous for the Il10tm1Cgn targeted mutation are viable and fertile when housed under SPF conditions. This mutant develops type 1 diabetes at the same rate as the NOD/Lt parental strain. The Il10 tm1Cgn mutation also renders this NOD/Lt stock susceptible to colitis (although not as severe as other strains of Il10 deficient mice) when maintained under standard housing conditions.
011066 NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJGckRolyJ
Cryopreserved - Ready for recovery
These mutant mice carry the Prkdcscid and Il2rgtm1Wjl alleles and the Tg(IL3)1Ygy, Tg(CSF2)2Ygy and Tg(KITLG)3Ygy transgenes. The Tg(CSF2)2Ygy transgene contains the porcine colony stimulating factor 2 (granulocyte-macrophage) sequence (CSF2) under the control of the human cytomegalovirus promoter. The Tg(IL3)1Ygy transgene contains the porcine interleukin 3 sequence under the control of the human cytomegalovirus promoter. The Tg(KITLG)3Ygy transgene contains the porcine kit ligand (KITL) under the control of the human cytomegalovirus promoter. The 3 transgenes were coinjected together in the original transgenic strain used to generate this mutant strain.
004848 NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/SzJ
Cryopreserved - Ready for recovery
Mice that are homozygous for both targeted mutations are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities when housed under specific pathogen free conditions. These double homozygote mutant mice have no mature T or B lymphocytes, no detectable NK cell cytotoxic activity, and lack serum immunoglobulin. The number of nucleated spleen cells is significantly reduced in double mutant mice, when compared to the single homozygote, NOD.129S7(B6)-Rag1tm1Mom/J (Stock No. 003729). Although an increased number of DX5+CD122+ NK cells are found in the spleens of double mutants, these NK cells have impaired cytotoxic activity. The disruption of Prf1 ablates NK cell cytotoxic activity resulting in increased engraftment levels over that observed with Stock No. 003729. All mutant mice develop thymic lymphomas. This double mutant mouse strain may be useful in studies involving engraftment of human hematolympho .....
For more information please see the full phenotype on the strain data sheet
010542 NOD.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
Cryopreserved - Ready for recovery
These L2G85.NOD mice harbor the CAG-luc-eGFP L2G85 transgene. Mice homozygous for the CAG-luc-eGFP L2G85 transgene are viable and fertile, with widespread expression of firefly luciferase and enhanced green fluorescence protein directed by the CAG promoter (human cytomegalovirus immediate early promoter enhancer with chicken beta-actin/rabbit beta-globin hybrid promoter). Bioluminesence is detected in heart, spleen, muscle, pancreas, skin, thymus and bone marrow. Luciferase activity is not detected in mature erythrocytes, although low levels are detected in erythrocyte precursors and varying levels of activity in all leukocyte subsets tested. Homozygotes have no reported gross physical or behavioral abnormalities. Following luciferin injection, luciferase expression is generally greater in males than females. GFP fluorescence is detected in skin (upper epidermal layers) by fluorescence microscopy. The Donating Investigator reports that for the FVB-Tg(CAG-luc,-GFP)L2G85Chco/J (STOC .....
For more information please see the full phenotype on the strain data sheet
008549 NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
Cryopreserved - Ready for recovery
Unmanipulated NOD congenic Itgax-DTR/EGFP (Cd11c-DTR) transgenic mice are viable, normal in size and develop spontaneous diabetes similar to NOD/ShiLtJ. All splenic CD8+ and CD8- DC express EGFP and are diphtheria toxin (DT) sensitive. Upon DT administration, mice harboring this transgene are transiently depleted of dendritic cell (DC) populations. Immunohistochemical and flow cytometric analysis reveals EGFP expression and DT-inducible depletion of CD11chigh DC in spleen, lymph node, lung, liver and lamina propria tissues, as well as the defined macrophage subpopulations of the alveolar, lamina propria, metallophillic and marginal zone. Rapid reduction of CD11c+ DC populations induced by intraperitoneal injection of DT persists for approximately 2 days, after which the cell population gradually recovers. While transient DC depletion was not associated with sign of illness or long-term defects, repeated DT inductio .....
For more information please see the full phenotype on the strain data sheet
003118 STOCK Ces1ce Foxn1nu/J
Cryopreserved - Ready for recovery
Mice homozygous for Ces1ce are viable and fertile and exhibit no apparent defect.

Ces1ce was discovered in a screen of progeny of triethylenemelamine (TEM) treated male mice for mutations at specific loci, but appears to have pre-existed in the male. The screen employed analysis of blood and kidney homogenates by "standard starch gel electrophoresis techniques" and focused on enzymes known to differ in electrophoretic mobility between the parental strains (DBA/2J and C57BL/6J). Ces1ce was initially thought to be a null allele, but characterization of homozygous F2 mice demonstrated presence of a faint band migrating between those of the parental strains, which was not perceived in the presence of either parental band. Thus, Ces1ce was shown to be a hypomorphic electrophoretic variant (Soares 1979).

The two main defects of mice homozygous for the nude spontaneous mutation (Foxn1nu, formerly <> .....
For more information please see the full phenotype on the strain data sheet

005707 STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
Cryopreserved - Ready for recovery
Mice homozygous for both the targeted mutation and the transgene are viable and fertile. The transgene beta-galactosidase is well expressed, reflects endogenous Tek/Tie2 activity, and is specific to the vascular endothelium. Mice homozygous for the Rag1 mutation are immunodeficient as they lack mature B and T lymphocytes. This double mutant mouse may be useful in studies of cancer, tumor-related angiogenesis, and as a recipient of xenografted tumors.
007896 STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
Cryopreserved - Ready for recovery
Mice hemizygous for this ROSA26-EGFP BAC transgene are viable and fertile, with widespread EGFP expression in all organs and tissues analyzed. In addition, stable and uniform EGFP expression is observed in differentiated progeny of transplanted hematopoietic stem cells (HSC) isolated from ROSA26-EGFP mice. These ROSA26-EGFP BAC transgenic mice may be useful for fluorescent labeling of cells and tissues both in vivo and in vitro, are suitable for use in histological preparations, and are appropriate as a source of fluorescently labeled donor cell populations (such as tracking hematopoietic cell fate in transplant recipients).
002574 NOD.129P2(B6)-Il4tm1Cgn/Dvs
Research Strain
Complete Freund's adjuvant (CFA) induced suppression of diabetes in NOD mice has been associated with a shift to Th2 cytokine production. NOD mice deficient in IL4 were created to investigate the role of IL4 in this shift. Mice homozygous for the Il4tm1Cgn targeted mutation are viable and fertile. T and B cell development is normal but IgG1and IgE levels and the ability of homozygous mutant mice to produce Th2-derived cytokines are significantly reduced. IL4 deficient NOD mice develop IDDM with the same incidence as standard NOD/Lt controls, and there is no change between IL4 deficient and wildtype NOD in disease protection conferred by treatment of bacillus Calmette-Guerin vaccine (BCG) or CFA. Both IL4 deficient and wildtype NOD mice are significantly protected from insulitis by treatment of CFA but not by treatment of BCG. (Serreze et al 2001)

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New Strains Awaiting Transfer from the Donor

(See informational text following listing of strains)
How to Register Interest
Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.

View a Data sheet for New Strains Awaiting Transfer
Select the strain name to link to the strain data sheet.

Stock
Number
Strain Name
 
Strain Description
Standard Supply
024511B6.Cg-Tcf12tm3Zhu Tcf3tm4Zhu/J
Awaiting Transfer from the Donor
HEBf E2Af mice allow Cre-recombinase inducible deletion of the two basic helix-loop-helix (bHLH) E-protein family genes HEB and E2A. These mice may be useful for studying B and T lymphocyte development and lymphoid malignancies.
025854B6.FVB-Ptprca Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
Awaiting Transfer from the Donor
Mice harboring the CAG-luc-eGFP L2G85 transgene exhibit widespread expression of firefly luciferase directed by the CAG promoter, making them useful in studies of transplantation, noninvasive lineage mapping, in vivo bioluminescence imaging and technology development.
025627C57BL/6-Tg(Scgb1a1-TFRC/OVA)1Adl/BmedJ
Awaiting Transfer from the Donor
CC10-OVA transgenic mice have expression of a membrane-bound exogenous antigen (ovalbumin with OT-1 and OT-11 epitopes) directed to large and small airway epithelium of the lungs by the rat Clara cell secretory protein promoter. These mice are useful for modeling antigen-specific, T-cell mediated acute bronchiolitis/pneumonitis as well as lung pathology similar to humans with acute lung transplant rejection and virus-induced lung injury.
017712C;129S4-Rag2tm1.1Flv Csf1tm1.1(CSF1)Flv Csf2/Il3tm1.1(CSF2,IL3)Flv Thpotm1.1(TPO)Flv Il2rgtm1.1Flv Tg(SIRPA)1Flv/J
Awaiting Transfer from the Donor
MISTRG are Rag2-deficient, Il2rg-deficient mice with human versions of four cytokines important for innate immune cell development (M-CSFh;IL-3/GM-CSFh;hSIRPAtg;TPOh;Rag2-;γc-). MISTRG mice are highly permissive for human hematopoiesis; supporting the development and function of monocytes, macrophages and NK cells derived from human fetal liver or adult CD34+ progenitor cells. MISTRG is a humanized mouse for modelling the human immune system in scenarios of health and pathology, such as human cell engraftment and patient-derived tumor xenografts (PDX).
017711C;129S4-Rag2tm1.1Flv Csf1tm1.1(CSF1)Vlcg Csf2/Il3tm1.1(CSF2,IL3)Flv Thpotm1.1(TPO)Flv Il2rgtm1.1Flv/J
Awaiting Transfer from the Donor
MITRG are Rag2-deficient, Il2rg-deficient mice with human versions of three cytokines important for innate immune cell development (M-CSFh;IL-3/GM-CSFh;TPOh;Rag2-;γc-). MITRG mice are highly permissive for human hematopoiesis; supporting the development and function of monocytes, macrophages and NK cells derived from human fetal liver or adult CD34+ progenitor cells. MITRG is a humanized mouse for modelling the human immune system in scenarios of health and pathology, such as human cell engraftment and patient-derived tumor xenografts (PDX).

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New Strains Awaiting Transfer from the Donor
  • Receive periodic updates on the status of the colony AWAITING TRANSFER
  • Obtain advance notification of strain availability and opportunity to order prior to the strain being published as available
  • Provide input affecting speed and quantity of availability
The Jackson Laboratory serves as a worldwide distributor and national repository for common and rare strains of inbred mice and mice carrying spontaneous mutations or induced mutations (i.e., transgenic, targeted/"knockout", or chemically induced mutations). At any one time, we have over 100 strains at various stages of development and colony expansion.

It is VERY IMPORTANT that you register interest in strains Awaiting Transfer. The anticipated demand for a strain enables us to determine effectively the distribution plan for each strain. Registering interest also provides benefits to you (including advance notification of pending availability). Whether a strain is made available from a live colony OR from our cryopreservation repository, you may want to consider the option of Dedicated Supply. To learn more about Dedicated Supply, go to Services.

Additional Register Interest Strains

Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.

View a Data sheet for a Strain
Select the strain name to link to the strain data sheet.

Stock
Number
Strain Name
 
Strain Description
Standard Supply
014553NOD.Cg-Hgftm1.1(HGF)Aveo Prkdcscid Il2rgtm1Wjl/J
In Progress
NSG-hHGFki mice are NOD.scid.Il2Rγcnull ("NSG") animals with the Hgftm1.1(HGF)Aveo "humanized" knock-in allele (hHGFki). Homozygous NSG-hHGFki mice have no mature T cells or B cells, lack functional natural killer (NK) cells, are deficient in cytokine signaling, and express human hepatocyte growth factor (HGF) in place of the endogenous mouse HGF. These mice may be useful in studying the HGF/MET pathway in human tumor xenografts and mouse tumor allografts, as well as examining the ability of anti-HGF to inhibit angiogenesis and other tumor/stroma interactions.

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It is VERY IMPORTANT that you Register Interest. The anticipated demand for a strain enables us to determine effectively the distribution plan for each strain.

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