Search Criteria: Research Area is "Reproductive Biology Research: Meiotic Nondisjunction Studies"
| Stock Number |
Strain Name Phenotype |
Standard Supply |
| 000654 | CBA/CaJ | Level 2 |
| The CBA inbred strain was initially bred for longevity and a low incidence of spontaneous mammary tumors (compared with C3H). Burdette and Strong reported that CBA mice were comparatively susceptible to tumor induction after a single subcutaneous injection of methylcholanthrene. The tumor types identified in this early work in CBA mice included spindle cell sarcoma, rhabdomyosarcoma, and epidermoid carcinoma. Strong and Smith reported finding benign hepatomas in aging CBA mice. Several groups confirmed this finding, and the majority of studies found a higher frequency of spontaneous hepatomas in males than in females.
CBA/Ca mice are commonly used for leukemogenesis research because this strain has a low spontaneous incidence of leukemia but has a relatively high inducibility of myeloid leukemia in response to benzene and radiation exposure. Multiple reports using CBA, its F1 hybrids, and other strains, have indicated that deletions in a specific segment of chromosome 2 are linked
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| 000250 | BNT/LeJ | Repository-Cryopreserved |
| In the early 1950s, a wild type female from the Namru strain was crossed with a bald hrba/hrba male and one of the pups produced was a male with a bent tail. Pedigree tests revealed the underlying mutation to be semidominant and carried on the X chromosome. The predominant phenotypic trait of kinked, shortened tails results from mis-formed, smaller, and absent tail vertebrae. Heterozygous females have varied expressivity spanning a broad phenotypic range including mice with no apparent phenotype and mice with multiply kinked and shortened tails. Hemizygous males have the highest expressivity; the tail is shortened in some cases to half the normal length and in the most severe cases the kinks in the tail will cause the tail to bend sharply. In males the tail kinks are more common in the distal than the proximal half of the tail. Heterozygous females are fertile, but hemizygous males and homozyous females have decreased viability and fertility. T
..... For more information please see the full phenotype on the strain data sheet | ||
| 001529 | C3H/HeSn-Paf/J | Repository-Cryopreserved |
| This strain has delayed disjunction of the X and Y chromosomes. XPaf/X females have patchy or striped coats; XPaf/Y males have a dark, shiny coat until hairloss begins and between 12 and 30 days of age the coat loses underfur and becomes sparse and then bristly; XPaf/O females initially have a dark shiny coat which looks like that of XPaf/Y males but then they lose less fur than the XPaf/Y male and appear more striped or patched than heterozygous females, but do not become bristly or have as sparse a coat as hemizygous males. | ||
| 002602 | C57BL/6JEi-Chr YA/HeJ/EiJ | Repository-Cryopreserved |
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