Search Criteria: Research Area is "Neurobiology Research: Fragile X Mental Retardation Syndrome"

New Strains Under Development

JAX^® Mice Strains

Stock Number	Strain Name   Strain Description	Standard Supply
004624	FVB.129P2-Fmr1tm1Cgr/J	Repository- Live
	Mice that are homozygous for the targeted mutation are viable and fertile. Quantitative morphological analysis of dendritic spines of visual cortex pyramidal cells reveals mutant mice have more long dendritic spines, fewer short dendritic spines and more spines with an immature morphology than wildtype littermates. These mice were backcrossed for 11 generations onto the FVB background, are homozygous for the 129P2/OlaHsd wildtype Pde6b allele and do not suffer from blindness due to retinal degeneration. This mutant mouse strain may be useful in studies related to Fragile X Syndrome.
003025	B6.129P2-Fmr1tm1Cgr/J	Cryopreserved - Ready for recovery
	Mice homozygous for the Fmr1tm1Cg targeted mutation show macroorchidism (enlarged testes), learning deficits, and hyperactivity. Macroorchidism in caused by an increased rate of Sertoli cell proliferation during embryogenesis which may be independent of FSH signalling. Comparison of homozygotes to wildtype littermates in hidden- and visible-platform water maze learning showed deficits in spatial learning and motor performance.
003024	FVB.129P2(B6)-Fmr1tm1Cgr/J	Cryopreserved - Ready for recovery
	Mice homozygous for the Fmr1tm1Cg targeted mutation show macroorchidism (enlarged testes), learning deficits, and hyperactivity. Macroorchidism in caused by an increased rate of Sertoli cell proliferation during embryogenesis which may be independent of FSH signalling. Comparison of homozygotes to wildtype littermates in hidden- and visible-platform water maze learning showed deficits in spatial learning and motor performance.
002700	FVB;129P-Fmr1tm1Cgr/J	Cryopreserved - Ready for recovery
	Mice homozygous for the Fmr1tm1Cg targeted mutation show macroorchidism (enlarged testes), learning deficits, and hyperactivity. Macroorchidism in caused by an increased rate of Sertoli cell proliferation during embryogenesis which may be independent of FSH signalling. Comparison of homozygotes to wildtype littermates in hidden- and visible-platform water maze learning showed deficits in spatial learning and motor performance.

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New Strains Under Development

(See informational text following listing of strains)

How to Register Interest
Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.

View a Data sheet for New Strains Under Development
Select the strain name to link to the strain data sheet.

	Stock Number	Strain Name   Strain Description	Standard Supply
	010504	B6.129-Fmr1tm1(I304N)Rbd/J	Under Development for Production
	These mice recapitulate the phenotype of null Fmr1 (fragile X mental retardation syndrome 1 homolog) allele mice in terms of increased macroorchidism with age, protein synthesis-dependent metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) at CA1 hippocampal neurons, and performance in multiple behavioral assays. This strain may be useful in studies of Fragile X Mental Retardation Syndrome.
	008909	FVB.129-Fmr1tm1Rbd/J	Under Development for Production
	These mice recapitulate the phenotype of null Fmr1 (fragile X mental retardation syndrome 1 homolog) allele mice in terms of increased macroorchidism with age, protein synthesis-dependent metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) at CA1 hippocampal neurons, and multiple behavioral assays. There is a significant incidence of audiogenic seizures in adulthood. Protein levels are decreased to 15-30% that of wildtype at P14, but normalize somewhat in adulthood. This strain may be useful in studies of Fragile X Mental Retardation Syndrome.

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New Strains Under Development

• Receive periodic updates on the status of the colony UNDER DEVELOPMENT
• Obtain advance notification of strain availability and opportunity to order prior to the strain being published as available
• Provide input affecting speed and quantity of availability

The Jackson Laboratory serves as a worldwide distributor and national repository for common and rare strains of inbred mice and mice carrying spontaneous mutations or induced mutations (i.e., transgenic, targeted/"knockout", or chemically induced mutations). At any one time, we have over 100 strains at various stages of development and colony expansion. Strains "Under Development" fall into two categories depending on the anticipated demand from the scientific community.

1. Strains that will be made available from a live distribution colony at The Jackson Laboratory.
   These strains are designated as: "Under Development for Distribution Colony"
2. Strains that will be made available through the Cryopreservation Repository.
   These strains are designated as: "Under Development for Cryopreservation Repository"

It is VERY IMPORTANT that you register interest in strains Under Development. The anticipated demand for a strain enables us to determine effectively the distribution plan for each strain Under Development. Registering interest also provides benefits to you (including advance notification of pending availability). Whether a strain is made available from a live colony OR from our cryopreservation repository, you may want to consider the option of Dedicated Supply. To learn more about Dedicated Supply, go to Services.

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