Search Criteria: Research Area is "Immunology and Inflammation Research: Autoimmunity (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 006360 | NOD.129S2(B6)-Airetm1.1Doi/DoiJ | Repository-Cryopreserved |
| Autoimmune regulator, Aire, located on Chromosome 10, 41.6cm controls, in part, ectopic gene expression involved with tolerance induction, and is specifically involved with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy in humans. Exon 2 and portions of the flanking introns of the Aire gene were deleted by Cre-lox-mediated homologous recombination. Analysis of the mutated Aire transcript identified a frameshift that precludes translation past exon 1. The Aire mutation originated on a 129B6F2 background and was backcrossed to NOD for 12 generations. NOD.Aire deficient mice are normoglycemic, but experience weight loss between 5 and 15 weeks of age. Approximately 79% die spontaneously or must be euthanized due to declining health at between 6 and 14 weeks of age. Pathology indicates lung lesions with generalized pneumonitis, severe exocrine (not endocrine) pancreatitis and lymphocytic infiltration in the liver, salivary, stomach, reprodu
..... For more information please see the full descriiption on the strain data sheet | ||
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