Search Criteria: Research Area is "Immunology and Inflammation Research: Autoimmunity (anti-dsDNA antibodies)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 007716 | B6.NZB-(D1Mit47-D1Mit209)/BkotJ | Repository- Live |
| Mice homozygous for the NZB/BlNJ-derived lupus susceptibility QTL (Nba2) on the C57BL/6 background develop elevated serum IgG antinuclear antibodies, a two-fold increase in the number of spleen cells (by 10 weeks of age), an increase in the absolute number of B and T cells, early B cell activation, increased levels of IgM, a two-fold increase in activated (CD69+) B cells and a two fold increase in FAS+ B cells. Although approximately 10% of females older than 10 months of age develop high levels of proteinuria, the subsequent nephritis does not result in death. When crossed with NZW/LacJ mice, 95% of F1 hybrid females develop elevated autoantibodies, severe proteinuria and fatal nephritis. This strain may be useful in dissecting the genetics of systemic lupus erythematosus. | ||
| 007173 | C.129X1(B6)-Ptprctm1Weis/J | Repository-Cryopreserved |
| Mice homozygous for this targeted point mutation are viable and fertile. The phenotype of this mutation, which inactivates the inhibitory wedge of the protein, is dependent upon the genetic background. On the BALB/c background, B, T, and myeloid cells are hyperresponsive to stimulation at a biochemical and cellular level. B cell development is skewed to the B1 cell lineage. A mild lymphoproliferative disorder is developed. Mice develop anti-DS antibodies with 100% penetrance between 1.5 and 3 months of age, but no glomerulonephritis. Cell surface expression of the protein is indistinguishable from wildtype as determined by flow cytometry of hematpoietic lineages in bone marrow, lymph node, spleen, thymus, peritoneal lavage, and peripheral blood. | ||
| 001723 | CByJ.A-Ttc7fsn/J | Repository-Cryopreserved |
| Homozygous fsn mice suffer from hypochromic and normocytic anemia at birth which becomes more severe with age. The anemia makes the homozygous mice distinguishable as pups because of the pale color of ears and eyes. At 2 weeks of age focal epidermal hyperplasia and inflammation is evident with psoriasiform skin lesions becoming confluent and diffuse in 3-4 week old weanlings. The skin lesions progress to generalized alopecia and shedding of thick white scales. The gross lesions are accompanied by thickening and keratinization of the skin. A progressive paplosquamous disease ensues which is a model for some forms of psoriasis. fsn/fsn mice show hematocrit levels and red blood cell counts that are significantly decreased from birth through adulthood. Consequently the heart, liver and spleen become enlarged but the thymus weight is less than half normal. As the spleen enlarges, the mice also develop a potbellied appearance aiding in homozygous fsn identification. G
..... For more information please see the full descriiption on the strain data sheet | ||
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