Search Criteria: Research Area is "Sensorineural Research: vomeronasal system defect"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 006653 | 129S-Del(6)1Mom/MomJ | Repository-Cryopreserved |
| Using chromosome engineering technology, an approximately 600 kilobase genomic region was deleted that contains a cluster of 16 intact V1r vomeronasal receptor genes. The mutant mice display deficits in a subset of VNO-dependent behaviors: the expression of male sexual behavior and maternal aggression is substantially altered. Electrophysiologically, the epithelium of the VNO of such mice does not respond detectably to specific pheromonal ligands. | ||
| 006633 | STOCK V1rb2tm3Mom/MomJ | Repository-Cryopreserved |
| This mutation causes a deletion of the coding region of the vomeronasal receptor V1rb2 and encodes two detectable tags. Vomeronasal sensory neurons that express the mutated locus co-express GFP and the taulacZ fusion protein by virtue of IRES-mediated co-translation. These neurons can be revealed by the intrinsic fluorescence of GFP, by immunofluorescence with anti-GFP antibodies, by histochemistry of beta-galactosidase enzymatic activity, or by immunofluorescence with anti-beta-galactosidase antibodies. There is a three fold diminution in neurons expressing this disrupted allele relative to those that express a tagged endogenous sequence, and the pattern of innervation of the accessory olfactory bulb differs, with axons failing to converge onto distinct glomeruli. | ||
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