Search Criteria: Research Area is "Neurobiology Research: Receptor Defects (GABA receptor)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 006874 | B6.129-Gabra4tm1.2Geh/J | Repository- Live |
| Mice homozygous for this GABAA-R alpha4F allele are viable and fertile. These mutant mice have loxP sites flanking exon 3 of the targeted gene. When bred to Cre-recombinase expressing mice, offspring will have a deletion of exon 3 in the cre expressing tissue(s). These "floxed" mice may be useful in neurological studies including behavior and neurotransmitter function. Of note, several strains bearing gamma-aminobutyric acid (GABA-A) receptor mutations are available from this donating investigator (Dr. Gregg Homanics, University of Pittsburgh), including Gabra1 (Stock No. 004318), Gabra4 (Stock No. 006874), Gabra6 (Stock No. 002710), Gabrb3 (Stock No. 002711), Gabrd (Stock No.
..... | ||
| 002711 | B6;129-Gabrb3tm1Geh/J | Repository- Live |
| The gamma-Aminobutyric acid type A receptors mediate the majority of rapid inhibitory synaptic transmission in the CNS. The beta3 subunit is an essential component of these receptors in many brain regions, especially during development, and is implicated in several pathophysiologic processes. The majority of mice homozygous for the Gabrb3tm1Geh mutation (or beta3-/-) die at birth with ~60% displaying cleft palate and the remaining ~35% die for unidentified reasons. Homozygous females that survive are fertile but do not care for their pups. Survivors have frequent myoclonus and occasional epileptic seizures, are hypersensitive to external stimuli and handling, have a lack of coordination and display altered responses to certain anesthesias. In addition, the observed behavioral deficits (especially regarding social behaviors) indicate that mutant mice may be a useful model of autism spectrum disorders. Of note, several strains bearing gamma-aminobutyric acid (GABA-A)
..... | ||
| 004318 | B6.129(FVB)-Gabra1tm1Geh/J | Repository-Cryopreserved |
| These mice possess loxP sites on either side of a Gabra1 exon encoding the second transmembrane domain. Mice that are homozygous for this floxed Gabra1 allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When used in conjunction with a Cre recombinase-expressing strain, this strain is useful in generating tissue-specific mutants of Gabra1. In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available. Of note, several strains bearing gamma-aminobutyric acid (GABA-A) receptor mutations are available from this donating investigator (Dr. Gregg Homan
..... | ||
| 003725 | B6.129-Gabrdtm1Geh/J | Repository-Cryopreserved |
| Mice that are homozygous null for Gabrd are viable and fertile. Northern blot analysis of -/- adult cerebellar RNA suggests that a chimeric Gabrd/neo transcript is generated from the targeted allele. Western blot analysis fails to detect a Gabrd protein product. Maximal binding for the agonist muscimol was markedly decreased in whole brain homogenates. Consistent with this, in situ autoradiographic analysis indicates a drastic reduction in muscimol binding in most parts of the brain. In general, these mice exhibit a decreased sensitivity to the sedative/hypnotic, anxiolytic and pro-absence effects of neuroactive steroids as determined by sleep time assays, elevated plus-maze assays (measures anxiolytic effect) and the inability of neuroactive steroids to prolong pentylenetetrazol-induced seizures. This decreased sensitivity appears to be selective however, as differential responses to various neuroactive steroids are observed. Of note, several strains bear
..... | ||
| 005811 | B6.129P2-Gabra3tm1Dgen/J | Repository-Cryopreserved |
| This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen. | ||
| 005812 | B6.129P2-Gabra4tm1Dgen/J | Repository-Cryopreserved |
| This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen. | ||
| 005810 | B6.129P2-Gabrptm1Dgen/J | Repository-Cryopreserved |
| This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen. | ||
| 005695 | B6.129S-Galr1tm1Tpi/J | Repository-Cryopreserved |
| Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical abnormalities. No gene product (mRNA) is detected by RT-PCR analysis of mRNA from brain, spinal cord and uterus tissue. Although galanin receptor 1 targeted mutant mice on an incipient congenic B6.129S(N6) genetic background have been described to sometimes exhibit spontaneous seizures triggered by handling or bright light conditions, the donating investigator indicates that this mouse strain does not exhibit seizure behavior. | ||
| 002710 | B6;129-Gabra6tm1Geh/J | Repository-Cryopreserved |
| Mice homozygous for the Gabra6tm1Geh mutation are viable and fertile with no gross abnormalities. There were no differences detected in behavioral response to ethanol comparing homozygotes to wildtypes from the two background strains, C57BL/6 and 129/SvJ. This findings suggest that the alpha6 subunit of the gamma-aminobutyric acid type A receptor exerts little if any influence on acute functional tolerance, withdrawal hyperexcitability, or protracted tolerance. The only defects discovered thus far are pharmacologic. Of note, several strains bearing gamma-aminobutyric acid (GABA-A) receptor mutations are available from this donating investigator (Dr. Gregg Homanics, University of Pittsburgh), including Gabra1 (Stock No. 004318), Gabra4 (Stock No. 006874), Gabra6 (Stock No. 002710), Gabrb3 (Stock No.
..... | ||
| 003137 | B6;129-Gabrg2tm1Geh/J | Repository-Cryopreserved |
| The gamma subunit of the gamma aminobutyric acid type A receptor is essential for bestowing both normal single channel conductance and sensitivity to benzoidiazepines. Alternate RNA splicing produces two alternative forms of the gamma2 subunit from Gabrg2. The two forms, gamma2L and gamma2S are expressed in different brain regions. This strain is a knockout of the gamma2L form. Mice homozygous for this exon deletion are viable and superficially indistinguishable from wild type mice. Behaviorally, gamma2L knockout mice show increased levels of anxiety in the elevated plus maze relative to controls and also longer sleep time than control mice in response to midazolam and zolpidem. Of note, several strains bearing gamma-aminobutyric acid (GABA-A) receptor mutations are available from this donating investigator (Dr. Gregg Homanics, University of Pittsburgh), including Gabra1 (Stock No. 004318), Gabra4 (Stock No.
..... | ||
(10 stocks) Back to Top
Send questions to our Technical Support team using the Express Technical Support Form.
(3.2)