Search Criteria: Research Area is "Neurobiology Research: Receptor Defects (glutamate receptor: metabotropic)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 003558 | B6.129-Grm5tm1Rod/J | Repository-Cryopreserved |
| Long-term potentiation (LTP) in Grm5tm1Rod (mGluR5) targeted mutant mice was significantly reduced in the NMDA receptor (NMDAR)-dependent pathways such as the CA1 region and dentate gyrus of the hippocampus, whereas LTP remained intact in the mossy fiber synapses on the CA3 region, an NMDAR-independent pathway. These mutant mice were also impaired in the acquisition and use of spatial information in both the Morris water maze and contextual information in the fear-conditioning test. Homozygotes are viable and fertile. In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available. | ||
| 005814 | B6.129P2-Grm1tm1Dgen/J | Repository-Cryopreserved |
| This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen. | ||
| 005815 | B6.129P2-Grm3tm1Dgen/J | Repository-Cryopreserved |
| This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen. | ||
| 003121 | B6;129-Grm5tm1Rod/J | Repository-Cryopreserved |
| Mice homozygous for the targeted mutation are viable and fertile. Long-term potentiation (LTP) in homozygous mutant mice is significantly reduced in the NMDA receptor (NMDAR)-dependent pathways such as the CA1 region and dentate gyrus of the hippocampus, whereas LTP remains intact in the mossy fiber synapses on the CA3 region, an NMDAR-independent pathway. These mutant mice also show impairments in the acquisition and use of spatial information in both the Morris water maze and contextual information in the fear-conditioning test. | ||
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