Search Criteria: Research Area is "Neurobiology Research: Receptor Defects: opiod"

New Strains Awaiting Transfer from the Donor

JAX® Mice Strains

Stock
Number
Strain Name
 
Strain Description
Standard Supply
007558 B6.129S2-Oprk1tm1Kff/J
Repository- Live
Mice homozygous for this kappa-opioid receptor mutant allele (KOR-) are viable and fertile. KOR-selective ligand binding is absent on brain membranes from homozygous mice. In contrast to mutant mice deficient of delta- or mu-opioid receptors (Stock No. 007557 or 007559), KOR- homozygotes have normal mechanical pain thresholds, but greatly increased sensitivity to chemical visceral pain. KOR- homozygotes also exhibit normal spontaneous stress responses (unlike delta-opioid receptor null mice). Homozygous KOR- mice also show decreased ethanol self-administration and decreased THC-conditioned place aversion. These KOR mutant mice may be useful in studying biological activity of opioids, analgesics, spinally mediated thermal nociception and chemical visceral pain thresholds.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. These mut .....
For more information please see the full phenotype on the strain data sheet

007559 B6.129S2-Oprm1tm1Kff/J
Repository- Live
Mice homozygous for the mu-opioid receptor mutant allele Oprm1tm1Kff (or MOR-) are viable and fertile. MOR-selective ligand binding is absent on brain membranes from homozygous mice. Homozygous mice exhibit a lack of morphine analgesia, reward, and withdrawal. This is accompanied by decreased mechanical, thermal, and chemical pain thresholds. Homozygous mice also show decreased ethanol self-administration and decreased THC-conditioned place aversion. In contrast to mutant mice deficient of delta- or kappa-opioid receptors (Stock Nos. 007557 or 007558, respectively), Oprm1tm1Kff homozygotes exhibit hypolocomotive spontaneous stress responses. Indeed, the reduced anxiety and depressive-like behavior observed in Oprm1tm1Kff mutants is in stark contrast to kappa-opioid receptor deficient mice. These knock-out mice may be usef .....
For more information please see the full phenotype on the strain data sheet
011130 STOCK Arrb2tm1Rjl/J
Repository- Live
Homozygous Arrb2 (arrestin, beta 2) targeted mutation mice show a significantly increased potentiation and prolongation of the analgesic effect of morphine, suggesting that μ opioid receptor desensitization is impaired. They lack expression of the gene as determined by immunoblot of brainstem, periaqueductal gray tissue, spleen, lung, and skin. These mice may be useful in studies of pain and analgesia.
012431 B6.129-Adrbk2tm1Rjl/J
Cryopreserved - Ready for recovery
Adrbk2 (adrenergic receptor kinase, beta 2; also called GRK3) is the major G protein-coupled receptor kinase family member in olfactory neurons, and mice lacking GRK3 exhibit a deficit in desensitization to olfactants. In homozygous mice, airway smooth muscle cells exhibit supersensitivity to muscarinic agents, and brain neurons exhibit altered kappa opioid receptor-dependent tolerance. Expression is eliminated in olfactory neuroepithelium, brain, and airway smooth muscle cells.
007557 B6.129S2-Oprd1tm1Kff/J
Cryopreserved - Ready for recovery
Mice homozygous for this delta-opioid receptor mutant allele (DOR-) are viable and fertile. DOR-selective ligand binding is absent in vitro on brain membranes from homozygous mice. Unlike mutant mice deficient in kappa- or mu-opioid receptors (Stock No. 007558 or 007559, respectively), homozygous DOR- mutants exhibit increased anxiety and depressive-like behavior but no alteration of spontaneous pain perception. Homozygous DOR- mice also have increased ethanol self-administration and increased inflammatory pain. These DOR mutant mice may be useful in studying the biological activity of opioids andanalgesics, mechanical nociception, inflammatory pain, and emotional disorders.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first ch .....
For more information please see the full phenotype on the strain data sheet

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New Strains Awaiting Transfer from the Donor

(See informational text following listing of strains)
How to Register Interest
Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.

View a Data sheet for New Strains Awaiting Transfer
Select the strain name to link to the strain data sheet.

Stock
Number
Strain Name
 
Strain Description
Standard Supply
026221B6.Cg-Oprm1tm1.1Jbwa/J
Awaiting Transfer from the Donor
MOR KI mice contain a mutation in the Oprm1 gene which makes them useful for studying the development of opioid tolerance, addiction, and physical dependence.

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New Strains Awaiting Transfer from the Donor
  • Receive periodic updates on the status of the colony AWAITING TRANSFER
  • Obtain advance notification of strain availability and opportunity to order prior to the strain being published as available
  • Provide input affecting speed and quantity of availability
The Jackson Laboratory serves as a worldwide distributor and national repository for common and rare strains of inbred mice and mice carrying spontaneous mutations or induced mutations (i.e., transgenic, targeted/"knockout", or chemically induced mutations). At any one time, we have over 100 strains at various stages of development and colony expansion.

It is VERY IMPORTANT that you register interest in strains Awaiting Transfer. The anticipated demand for a strain enables us to determine effectively the distribution plan for each strain. Registering interest also provides benefits to you (including advance notification of pending availability). Whether a strain is made available from a live colony OR from our cryopreservation repository, you may want to consider the option of Dedicated Supply. To learn more about Dedicated Supply, go to Services.


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