Search Criteria: Research Area is "Neurobiology Research: Alzheimer's Disease (Bace mutants)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 004714 | B6.129-Bace1tm1Pcw/J | Repository- Live |
| Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. No gene product (protein) is detected by Western blot analysis of brain tissue. Primary cultures of cortical neurons isolated from homozygotes aged embryonic day 16.5 do not secrete amyloid beta peptides (Aβ1-40/42 or Aβ11-40/42) or beta C-terminal fragments (βCTFs). When transfected with a recombinant adenovirus expressing the mutant humanized Beta amyloid precursor protein (APP), hAPPSwe, cultured embryonic cortical neurons do not secrete detectable levels of Aβ1-40/42 or Aβ11-40/42 peptides. This mutant mouse strain may be useful in studies of Alzheimer's disease. | ||
| 005618 | B6;129P2-Bace2tm1Bdes/J | Repository-Cryopreserved |
| Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Transcripts derived from the targeted locus do not contain exon 6. One of the enzyme's active sites is encoded by exon 6 so consequently, proteins generated from the targeted locus lack beta-secretase activity. This mutant mouse strain may be useful in studies of Alzheimer's disease. | ||
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