Search Criteria: Research Area is "Cardiovascular Research: Hypotension (control for BPL/1@J)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 003004 | BPN/3J | Repository- Live |
| The normotensive BPN/3 inbred strain serves as a control for the high blood pressure (BPH/2, Stock No. 003005) and low blood pressure (BPL/1, Stock No. 003006) inbred strains BPH/2 mice have elevated systolic blood pressures at five weeks and by 150 days differ from the BPL/1 by 60 mmHg. The BPH/2 strain has a higher heart rate, larger hearts and kidneys, and higher hematocrits than the BPL/1. It also has lower renin, aldosterone and angiotensin I levels compared to the BPL/1 and BPN/3. The original HBP (high blood pressure) and LBP (low blood pressure) selected lines showed a number of biochemical and physiological differences which have not been reexamined in the inbred strains. These include differences in brain catecholamines, calmodulin concentrations, heat sensitivity, alcohol preference, and longevity. The differences in longevity were striking. The hypotensive selected lines lived two to three hundred days longer, on average, than the hypertensive selected line. Biometrical ge
..... For more information please see the full descriiption on the strain data sheet | ||
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