Search Criteria: Research Area is "Cancer Research: Oncogenes"
Strains from the Research Colonies of Jackson Laboratory Scientists
New Strains Under Development
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 100410 | WBB6F1/J-KitW/KitW-v/J | Level 2 |
| Kit mutant mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. KitW-v homozygotes resemble KitW homozygotes in color, anemia, and germ cells, but many of them survive to maturity. The lack of germ cells in mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. KitW/KitW-v double heterozygotes are viable but sterile because of germ cell deficiency. They are also mast cell deficient. KitW/KitW-v double heterozygotes lack intermediate cells, derived from melanoblasts, in the stria vascularis resulting in endocochlear degeneration, loss of endocochlear potential, and hearing impairment. | ||
| 002376 | FVB/N-Tg(MMTVneu)202Mul/J | Level 3 |
| Mice homozygous for the MMTVneu (rat) transgene are viable and fertile. There is no phenotypic effect in males. The transgene is expressed at low levels in normal mammary epithelium, salivary gland, and lung. Higher expression is detected in tumor tissue. Focal mammary tumors first appear at 4 months, with a median incidence of 205 days. Both virgin and breeder mice develop tumors. Tumors arise as foci in hyperplastic, dysplastic mammary glands. Seventy-two percent of tumor-bearing mice that live to 8 months or longer develop metastatic disease to the lung. The phenotype of MMTV/unactivated neu transgenic mice differs from that of the MMTV/activated neu produced by Phil Leder, in which multifocal tumors involving the entire mammary epithelium arise. | ||
| 000049 | C57BL/6J-KitW-v/J | Level 4 |
| Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. KitW-v homozygotes resemble KitW homozygotes in color, anemia, and germ cells, but many of them survive to maturity. The lack of germ cells in mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. | ||
| 000692 | WB/ReJ KitW/J | Level 4 |
| Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. The lack of germ cells in homozygous mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. | ||
| 004293 | 129-Shhtm2Amc/J | Repository- Live |
| Mice that are homozygous for the Shhtm2Amc targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This conditional mutant contains two loxP sites flanking exon 2 of the targeted allele. Cre-mediated recombination excises exon 2 and some surrounding intronic sequence, generating a null allele. When the conditional mutant is crossed with a ubiquitously-expressing Cre recombinase carrier to remove Shh activity in the early embryo, the resulting phenotype resembles the Shh null mutation. These conditional mutant mice may be mated to strains expressing Cre recombinase to study the effects of temporal and tissue-specific ablation of the targeted allele. This mutant mouse strain represents a model that may be useful in studies of developmental defects resulting from disruption of Shh-dependent pathways.
When bred to a strain expressing Cre recombinase under the control of a tet
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| 008179 | B6.129S4-Krastm4Tyj/J | Repository- Live |
| This strain carries a point mutation (G12D) whose expression is blocked by the presence of a loxP-flanked stop codon. Homozygotes die in utero. Cre-mediated recombination can excise the stop codon and permit the oncogenic protein to be expressed. Intranasal infection with an adenovirus encoding Cre results in a very high frequency of lung tumors and permits controlled timing of tumor initiation and tumor multiplicity. This strain may be useful in studies of cancer and development. When bred to a strain expressing Cre recombinase under the control of a tetracycline-responsive promoter element and a strain expressing a tetracycline-controlled activator protein in lung epithelial cells (see Stock No. 006234 and 006235 respectively), this mutant mouse strain may be useful in studies of lung development.
When bred to a strain expressing Cre recombinase in the male g
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| 002728 | B6.Cg-Tg(IghMyc)22Bri/J | Repository- Live |
| Expression of the mouse Myc transgene is restricted to the B cell lineage. Hemizygotes show increased pre-B cells in the bone marrow throughout life and a transient increase in large pre-B cells in the blood at 3-4 weeks of age. Spontaneous pre-B and B cell lymphomas reach an incidence of 50% at 15-20 weeks in hemizygous progeny of a wildtype female mated with a hemizygous male. The transgene synergizes with an TgN(BCL2)22Wehi transgene (Stock No. 02319) to produce primitive lymphoid tumors within 5 weeks of birth, and with an Emu-v-abl transgene to produce plasmacytomas by 8 weeks. | ||
| 002385 | B6;129S7-Fyntm1Sor/J | Repository- Live |
| Mice homozygous for the Fyntm1Sor targeted mutation are viable and fertile displaying no overt phenotype. T cell receptor signaling is defective in homozygous mutant mice and are characterized by a reduction in levels of tyrosine-phosphorylated proteins, failure to flux calcium in response to TCR cross-linking, and a reduction in production of calcium-related IL2. THY-1-induced proliferation is also reduced in thymocytes but not in splenic T cells. Neurological defects include blunted long-term potentiation (LTP), impaired special learning, and altered hippocampal development. | ||
| 003127 | FVB;129P2-Bcl3tm1Ver/J | Repository- Live |
| Mice homozygous for the Bcl3 targeted mutation are viable and fertile and display no alterations in their behavior or gross anatomy. While normal numbers of both T and B cell lymphocytes are produced, homozygous mutants display severe defects in humoral immune responses. Normal immunoglobulin levels are observed, but the mice are unable to clear Listeria monocytogenes or Streptococcus pneumoniae, thus indicating the necessity of Bcl3 in the production of antigen-specific antibodies. Additionally, splenic white pulp is devoid of germinal centers in the homozygous null mice. | ||
| 002271 | 129-Fyntm1Sor/J | Repository-Cryopreserved |
| Mice homozygous for the Fyntm1Sor targeted mutation are viable and fertile displaying no overt phenotype. T cell receptor signaling is defective in homozygous mutant mice and are characterized by a reduction in levels of tyrosine-phosphorylated proteins, failure to flux calcium in response to TCR cross-linking, and a reduction in production of calcium-related IL2. THY-1-induced proliferation is also reduced in thymocytes but not in splenic T cells. Neurological defects include blunted long-term potentiation (LTP), impaired special learning, and altered hippocampal development. | ||
| 002674 | 129-Krastm1Tyj/J | Repository-Cryopreserved |
| Homozygous mice die at about embryonic day 12-13. They have a hypocellular fetal liver which also displays extensive cell death. They also appear to have a defect in both the hematopoietic cells and their microenvironment. | ||
| 002280 | 129-Yes1tm1Sor/J | Repository-Cryopreserved |
| Mice homozygous for the Yestm1Sor mutation display no overt phenotype. While this mutation appears to completely block Yes protein production in the brain and several adult tissues (P. Stein, unpublished observations), a catalytically inactive form of the protein (which lacks kinase domain sequences encoded by the mutated exon) is found in fibroblasts. It is unclear is this partial peptide provides any normal Yes function in vivo. | ||
| 006403 | 129S.B6-Tg(KRT14-Esr1/HRAS)1Pkha/J | Repository-Cryopreserved |
| Mice hemizygous for this "K14-ER:Ras" transgene are viable and fertile. Inducible expression of the ER:Ras fusion protein is observed in the epidermis following topical application of 4-hydroxytamoxifen (4OHT). Prolonged (4 weeks) induction of human H-RasG12V activity promotes the undifferentiated, proliferative phenotypic characteristics observed in epidermal cancer; including hyperplasia, increased mitotic index, decreased expression of differentiation markers and increased expression of beta-1 and beta-4 integrin subunits. H-RasG12V-induced skin abnormalities were entirely reversed within one month after 4OHT cessation. These mice have a similar 4OHT-inducible skin phenotype as the transgenic mice expressing human Raf-1[DD] (Stock No. 006661) or human Mek1R4F (Stock No. 006822), and may be useful in studies of the Ras/Raf/MEK/ERK cell proli
..... For more information please see the full descriiption on the strain data sheet | ||
| 002722 | 129S6/SvEv-Mostm1Ev/J | Repository-Cryopreserved |
| Mice homozygous for the Mostm1Ev targeted mutation are viable. Homozygous males are fertile; the littersize of homozygous females is markedly lower than that of wild type or heterozygous mice. Eggs lacking Mos undergo spontaneous parthenogenetic activation (extrusion of the second polar body and pronucleus formation without fertilization). Ovarian cysts develop in homozygous females as young as one month. Some of the ovarian cysts consist of several tissue types, including possible thyroid tissue, similar to about 10% of all benign cystic teratomas in human beings. | ||
| 000599 | B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J | Repository-Cryopreserved |
| 006564 | B6(C)-KitW-41J Gusbmps/BrkJ | Repository-Cryopreserved |
| Mice homozygous for the "mps" (mucopolysaccharidosis type VII or MPS VII) mutation are devoid of expression of the lysosomal enzyme beta glucuronidase. Homozygous animals are viable, but females have a deficiency in lactation. Skeletal and connective tissue anomalies in both males and females are believed to prevent successful breeding. As this mutation is recessive, heterozygous mice are phenotypically similar to wildtype. Homozygotes exhibit short and thickened long bones (smaller than heterozygous or wildtype littermates), "pug type" appearance of the nose, hepatomegaly, splenomegaly, corneal clouding, and deafness. In appearance, homozygous KitW-41J mice are mostly white with black eyes and brown or grey spots. MPS VII mice are a model of the beta glucuronidase enzyme deficiency in humans called Sly Disease. They may be useful in developing new therapies (enzyme replacement, cell transplantation, gene therapy) broadly applicable to other lysosomal storage disease
..... For more information please see the full descriiption on the strain data sheet | ||
| 008183 | B6.129S4(Cg)-Trp53tm2.1Tyj/J | Repository-Cryopreserved |
| Mice carrying this Trp53 (p53) R172H point mutation mimic human Li-Fraumeni Syndrome, both genotypically and phenotypically. Heterozygotes develop a broad spectrum of tumors with a mean survival time of 16 months. Prominent tumor types include osteosarcomas (often metastatic), hemangiosarcomas, B-cell lymphomas and a variety of carcinomas. Homozygous mice also develop a broad spectrum of tumors, particularly T-cell lymphomas, hemangiosarcomas, soft-tissue sarcomas, osteosarcomas, primitive tumors (particularly male teratocarcinomas), and a variety of epithelial carcinomas. Mutant protein is expressed at high levels in mouse embryonic fibroblasts, as determined by Western blotting. | ||
| 002723 | B6.129S6-Mostm1Ev/J | Repository-Cryopreserved |
| Mice homozygous for the Mostm1Ev targeted mutation are viable. Homozygous males are fertile; the littersize of homozygous females is markedly lower than that of wild type or heterozygous mice. Eggs lacking Mos undergo spontaneous parthenogenetic activation (extrusion of the second polar body and pronucleus formation without fertilization). Ovarian cysts develop in homozygous females as young as one month. Some of the ovarian cysts consist of several tissue types, including possible thyroid tissue, similar to about 10% of all benign cystic teratomas in human beings. | ||
| 002277 | B6.129S7-Srctm1Sor/J | Repository-Cryopreserved |
| Mice homozygous for the Srctm1Sor targeted mutation display osteopetrosis. Homozygous mutant mice are approximately one-third the size of normal wildtype siblings. Incisors fail to erupt. In general, long bones are shorter in length and show a partial absence of bone marrow. Src has been implicated in development, but its role may be masked by other tyrosine kinases. No overt phenotype is found in brain or platelets, where it is most highly expressed. Mice heterozygous for the Srctm1Sor mutation have no apparent abnormalities. | ||
| 002099 | B6.129X1-Fostm1Pa/J | Repository-Cryopreserved |
| Mice homozygous for the Fostm1Pa mutation show reduced placental and fetal weights, lack teeth, and have a significant pre-weaning loss of viability. Survivors grow at a normal rate until about 11 days of age when they begin to develop a severe osteopetrosis. They may live as long as 5-7 months. Homozygous mice have delayed or absent gametogenesis and show lymphopenia. They also exhibit behavioral abnormalities, including hyperactivity and diminished response to external stimuli. | ||
| 002100 | B6.129X1-Juntm1Pa/J | Repository-Cryopreserved |
| Mice homozygous for the Juntm1Pa targeted mutation die around embryonic day 12.5. Cultured fibroblasts from these embryos show reduced growth rates, even when cultured with various mitogens. | ||
| 000495 | B6.C-H38c/By-KitW-56J/J | Repository-Cryopreserved |
| 000560 | B6.C-H7b/By KitW-50J/J | Repository-Cryopreserved |
| 000122 | B6.C3-KitW-44J/J | Repository-Cryopreserved |
| KitW-44J heterozygotes have white-tipped feet and a white tail tip although the belly spot standardly found in KitW* mutations is very small in this mutant, sometimes restricted to only a few hairs. Homozygotes have a flecked pelt that is predominantly white, especially ventrally, with pigmented patches particularly at the lateral borders. The pigmentation fades with age yielding black-eyed white mice by approximately 9 months of age. While many KitW-44J homozygotes are viable, fertility is diminished. Homozygous females have greatly reduced fertility and gonads that are smaller in size with reduced activity. Homozygous males are sterile although spermatogenesis occurs. The KitW-44J allele does not produce anemia in either its heterozygous or homozygous state. The red blood cell count, white blood cell count, hematocrit, and mean cell volume are normal. However, bone marrow transplantation experiments reveal that t
..... For more information please see the full descriiption on the strain data sheet | ||
| 003479 | B6.C3-Tg(Fos-luc)1Rnd/J | Repository-Cryopreserved |
| C57BL/6-TgN(c-fosLuc)1Rnd mice are viable and fertile. They carry a firefly luciferase reporter gene driven by the c-fos promoter. The luciferase transgene is expressed constitutively in all tissues of these mice, at the lowest levels in kidney, liver, lung, spleen, heart and various areas of the brain, and at the highest levels in skin and testis. Activation of the c-fos promoter in response to a wide range of stimuli results in increased luciferase expression. C57BL/6-TgN(c-fosLuc)1Rnd mice provide a unique system to monitor c-fos promoter activity in living tissue explant or dispersed cell cultures. | ||
| 004853 | B6.C3-Tg(KRT14-Birc5)19Gros/J | Repository-Cryopreserved |
| These transgenic mice express the mouse baculoviral IAP repeat-containing 5, Birc5 (survivin), gene under the direction of the human keratin 14 promoter. Transgene expression is specific to epidermal and follicular keratinocytes. Mice hemizygous for the transgenic insert are resistant to chemical (DMBA)- and UVB-induced keratinocyte apoptosis in vivo. Although hemizygotes were less susceptible to DMBA-induced papilloma formation, spontaneous papilloma regression was not observed and there was enhanced conversion of papillomas to carcinomas. This mutant mouse strain represents a model that may be useful in studies of keratinocyte apoptosis and skin cancer development. | ||
| 000991 | B6.C58-KitW-57J/J | Repository-Cryopreserved |
| 000133 | B6.Cg-KitW-24J/J | Repository-Cryopreserved |
| 000139 | B6.Cg-KitW-25J/J | Repository-Cryopreserved |
| 000164 | B6.Cg-KitW/J | Repository-Cryopreserved |
| 000194 | B6.Cg-Lx KitW-v/J | Repository-Cryopreserved |
| Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. KitW-v homozygotes resemble KitW homozygotes in color, anemia, and germ cells, but many of them survive to maturity. The lack of germ cells in mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. Heterozygous lx mice show preaxial polydactyly (including hyperphalangy of the first digit) of the hindfeet. Homozygotes show preaxial polydactyly or oligodactyly of the hindfeet, reduction of the tibia, loss of part of the femur and pubis, decrease in number of presacral vertebrae, and anomalies of the urogenital system including horseshoe kidney, hydronephrosis, and hydroureter.
Although homozygous KitW-v/
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| 000171 | B6.D2-KitW-45J/J | Repository-Cryopreserved |
| 001563 | B6.D2-KitW-73J/J | Repository-Cryopreserved |
| 001177 | B6.LP-KitW-49J/J | Repository-Cryopreserved |
| 002443 | B6;129S-Rab3atm1Sud/J | Repository-Cryopreserved |
| Mice homozygous for the Rab3atm1Sud targeted mutation are viable, fertile, and comparable in weight and health to normal wild type siblings. Most of their synaptic parameters are normal, although synaptic depression after repetitive stimulation is significantly increased, suggesting a role for Rab3a in synaptic vesicle docking. Mutant mice do not express Rab3a and levels of rabphilin (a protein that associates with the GTP-bound form of Rab3) are decreased by 70%. Expression of over 20 other synaptic proteins is unchanged. | ||
| 002851 | B6;129S4-Relatm1Bal/J | Repository-Cryopreserved |
| Mice homozygous for the Relatm1Bal targeted mutation die at embryonic day 14 from hepatocyte apoptosis and failure of hematopoiesis | ||
| 002381 | B6;129S7-Srctm1Sor/J | Repository-Cryopreserved |
| Mice homozygous for the Srctm1Sor targeted mutation display osteopetrosis. Homozygous mutant mice are approximately one-third the size of normal wildtype siblings. Incisors fail to erupt. In general, long bones are shorter in length and show a partial absence of bone marrow. Src has been implicated in development, but its role may be masked by other tyrosine kinases. No overt phenotype is found in brain or platelets, where it is most highly expressed. Mice heterozygous for the Srctm1Sor mutation have no apparent abnormalities. | ||
| 002293 | B6;129X1-Fostm1Pa/J | Repository-Cryopreserved |
| Mice homozygous for the Fostm1Pa mutation show reduced placental and fetal weights, lack teeth, and have a significant pre-weaning loss of viability. Survivors grow at a normal rate until about 11 days of age when they begin to develop a severe osteopetrosis. They may live as long as 5-7 months. Homozygous mice have delayed or absent gametogenesis and show lymphopenia. They also exhibit behavioral abnormalities, including hyperactivity and diminished response to external stimuli. | ||
| 002404 | B6;CBA-Mostm1Ev/J | Repository-Cryopreserved |
| Mice homozygous for the Mostm1Ev targeted mutation are viable. Homozygous males are fertile; the littersize of homozygous females is markedly lower than that of wild type or heterozygous mice. Eggs lacking Mos undergo spontaneous parthenogenetic activation (extrusion of the second polar body and pronucleus formation without fertilization). Ovarian cysts develop in homozygous females as young as one month. Some of the ovarian cysts consist of several tissue types, including possible thyroid tissue, similar to about 10% of all benign cystic teratomas in human beings. | ||
| 006147 | B6;FVB-Tg(Sfpi1,-EGFP)7Dgt/J | Repository-Cryopreserved |
| Hemizygous mice are viable and fertile with no gross or behavioral abnormalities. Flow cytometry identifies enhanced green fluorescent protein (EGFP) reporter expression in a pattern similar to the endogenous gene; in bone marrow, high expression is observed in myeloid cells, and to a lesser degree in B lymphocytes and erythroid cells. Expression in spleen is consistent with B cells and natural killer cells, while no expression is observed in thymus. These mice may be useful in studies of hematopoietic cell development, transcription factor pathways, and leukemia (including erythroleukemia). | ||
| 002409 | B6;SJL-Tg(Wap-HRAS)69Lln Chr YSJL/J | Repository-Cryopreserved |
| The transgene integrated into the Y chromosome. These transgenics serve as models for male mammary cancer and ras-mediated solid tumors. The transgene also can be used as a Y-chromosome marker. On the B6,SJL background males develop multiple mammary tumors and salivary gland tumors by one year of age. The salivary tumors are adenocarcinomas arising from serous areas of the submandibular gland. The mammary gland tumors are adenosquamous carcinomas. Microscopic lung metastases were present in 14% of tumor bearing animals. On the FVB background males develop multiple mammary tumors at 6-8 weeks. The tumors are adenosquamous carcinomas with multiple foci of squamous differentiation or adenocarcinomas containing glandular tissue. There is no metastasis observed. | ||
| 000350 | B6By.Cg-KitW-v MitfMi-wh T/J | Repository-Cryopreserved |
| Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. KitW-v homozygotes resemble KitW homozygotes in color, anemia, and germ cells, but many of them survive to maturity. The lack of germ cells in mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. Mice homozygous for the white allele (MitfMi-wh) display an overall absence of pigment cells with the exception of the retina which expresses a few giving the eye a small amount of pigment. Homozygotes show slight microphthalmia but a normal skeleton. Heterozygotes (MitfMi-wh/+) have a dilut
..... For more information please see the full descriiption on the strain data sheet | ||
| 000627 | C3H/HeJ-KitW-x/J | Repository-Cryopreserved |
| 000847 | C3Sn.B6-KitW-39J/J | Repository-Cryopreserved |
| 008304 | C57BL/6-Nrastm1Tyj/J | Repository-Cryopreserved |
| This targeted mutant strain carries a loxP-flanked stop element in exon 1 and a G12D activating mutation in exon 2 of the neuroblastoma ras oncogene (Nras). This mutation functions as a null allele and has no apparent phenotype. Homozygotes are viable. Cre mediated excision of the floxed stop element causes a significant increase in GTP-bound N-Ras production. This conditional mutant strain may be helpful in further studies of this oncogene. | ||
| 000166 | C57BL/6J-KitW-17J/J | Repository-Cryopreserved |
| 000167 | C57BL/6J-KitW-18J/J | Repository-Cryopreserved |
| 000169 | C57BL/6J-KitW-20J/J | Repository-Cryopreserved |
| 000117 | C57BL/6J-KitW-34J/J | Repository-Cryopreserved |
| 000128 | C57BL/6J-KitW-35J/J | Repository-Cryopreserved |
| 000134 | C57BL/6J-KitW-37J/J | Repository-Cryopreserved |
| 000062 | C57BL/6J-KitW-39J/J | Repository-Cryopreserved |
| 000121 | C57BL/6J-KitW-40J/J | Repository-Cryopreserved |
| 000119 | C57BL/6J-KitW-41J/J | Repository-Cryopreserved |
| 000127 | C57BL/6J-KitW-42J/J | Repository-Cryopreserved |
| 000129 | C57BL/6J-KitW-43J/J | Repository-Cryopreserved |
| 000990 | C57BL/6J-KitW-55J/J | Repository-Cryopreserved |
| 001179 | C57BL/6J-KitW-62J/J | Repository-Cryopreserved |
| 000965 | CBACa.C3-KitW-x/J | Repository-Cryopreserved |
| 000092 | FL/1Re-KitW/J | Repository-Cryopreserved |
| 002677 | FVB.Cg-Tg(WapMyc)212Bri/J | Repository-Cryopreserved |
| Female mice transgenic for the Tg(WapMyc)212Bri are viable and fertile but do not lactate. Mammary glands from pregnant transgenic mice showed enlarged and hyperplastic alveoli with poorly differentiated epithelial cells. Multiparous females develop observable mammary tumors at the average age of 6 months. The majority of tumors were of mixed histotypes with solid as well as glandular or papillary foci. Lung metastases were observed in 3 of 14 tumor-bearing mice. All tumors tested were transplantable into syngeneic mice. | ||
| 002712 | FVB/N-Tg(PF4MER)6Kra/J | Repository-Cryopreserved |
| Mice homozygous for this transgene are viable and fertile. Expression of the transgene is exclusively in platelets and megakaryocytes in female carrier mice or in male carrier mice given injections of estrogen. Megakaryopoiesis is increased and they exhibit essential thrombocythemia. This strains serves as a model for a myeloproliferative disorder resembling essential thrombocythemia. Also known as PF4MER. | ||
| 000993 | NZB/BlNJ-KitW-59J/J | Repository-Cryopreserved |
| 003318 | STOCK Shhtm1Amc/J | Repository-Cryopreserved |
| Mice homozygous for the Shhtm1Amc targeted mutation display early defects in the establishment and maintenance of midline structures. These defects result from the critical role the Sonic hedgehog (Shh) gene plays in the patterning patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial skeleton and the limbs. Defects are also observed in all tissues, confirming the proposed role of SHH proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centers.
When bred to a strain with loxP sites inserted into the same targeted allele (Stock No. 004293) and a strain expressing Cre recombinase in the skin and dental epithelium (Stock No. 004782), this mutant mouse strain may be useful in studies of hedgehog signalling and cell proliferation in the dental e
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| 003690 | STOCK Tg(MMTV-Cdc37)1Stp/J | Repository-Cryopreserved |
| In wildtype mice Cdc37 is expressed primarily in proliferative tissues. These transgenic mice express Cdc37 under the direction of an MMTV promoter. As a result, levels of transgene mRNA are significantly higher than levels of endogenous Cdc37 in specific tissues (lacrimal, mammary, salivary glands, uterus and testis). Mice are born and develop normally. By 18 months of age females exhibit proliferative disorders including mammary tumors and lymphomas. By 22 months of age 100% of transgenic females develop mammary or lymphoid tumors. Histopathological examination indicates that mammary tumors are adenocarcinomas and adenosquamous carcinomas. Males expressing Cdc37 in mammary tissue develop a system of mammary ducts resembling that of virgin females, but do not develop tumors. Crosses with other MMTV-oncogene expressing mice indicate that Cdc37 can cooperate with myc in transformation of multiple tissues, and with Cyclin D1 in transformation of
..... For more information please see the full descriiption on the strain data sheet | ||
| 002600 | WLC/MorJ | Repository-Cryopreserved |
| WLC/MorJ represents a endogenous and exogenous MMTV-free genetic background. WLC/MorJ does not develop mammary tumors and no exogenous MMTV is detectable by PCR. WLC/MorJ serves as the strain background for WLC.C2-H2d.GR-Mtv2/Mor (Stock #003153). | ||
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IMPORTANT NOTE: Price information is on the strain data sheet which can be viewed by clicking on the strain name.
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 002410 | FVB.Cg-Tg(Wap-HRAS)69Lln Chr YSJL/J | Research Strain |
| The transgene integrated into the Y chromosome. These transgenics serve as models for male mammary cancer and ras-mediated solid tumors. The transgene also can be used as a Y-chromosome marker. On the B6,SJL background males develop multiple mammary tumors and salivary gland tumors by one year of age. The salivary tumors are adenocarcinomas arising from serous areas of the submandibular gland. The mammary gland tumors are adenosquamous carcinomas. Microscopic lung metastases were present in 14% of tumor bearing animals. On the FVB background males develop multiple mammary tumors at 6-8 weeks. The tumors are adenosquamous carcinomas with multiple foci of squamous differentiation or adenocarcinomas containing glandular tissue. There is no metastasis observed. | ||
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Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.View a Data sheet for New Strains Under Development
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- Strains that will be made available from a live distribution colony at The Jackson Laboratory.
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