Search Criteria: Research Area is "Dermatology Research: Color and White Spotting Defects (oculocutaneous albinism, type I)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 002565 | A.B6-Tyr+/J | Repository- Live |
| 000899 | C.B6-Tyr+ Hbbs/J | Repository- Live |
| 000090 | 129S1/Sv-Oca2+ Tyr+ KitlSl-J/J | Repository-Cryopreserved |
| The multiple steel mutations (KitlSl) behave in a semidominant fashion and cause deficiencies in pigment cells, germ cells, and blood cells paralleling those caused by the Kit locus mutations (dominant spotting alleles). Most of the alleles at steel locus cause severe anemia in utero and death by 15 to 16 days of gestation in homozygous mutant mice. However, compounds of two steel mutants (e.g. KitlSl/KitlSl-d) are viable, black-eyed white, are usually sterile in one or both sexes, and have severe macrocytic anemia. Heterozygous steel mice have a diluted coat color with a small amount of white spotting, are viable and fertile, and may have a slight macrocytic anemia. Primordial germ cells are absent in the nonviable steel homozygotes and severely reduced in steel heterozygotes. Mast cells are virtually absent in skin and other tissues of steel mutant mice. Tumors tend to develop in germ-cell-deficient ovaries with advancing a
..... For more information please see the full descriiption on the strain data sheet | ||
| 005445 | A.B6 Tyr+-Cybanmf333/J | Repository-Cryopreserved |
| View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page for nmf333 entry. | ||
| 005012 | A.B6 Tyr+-Myo5ad-l31J/J | Repository-Cryopreserved |
| View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page. | ||
| 001017 | AKXD10/TyJ | Repository-Cryopreserved |
| 000765 | AKXD13/TyJ | Repository-Cryopreserved |
| 000954 | AKXD15/TyJ | Repository-Cryopreserved |
| 000958 | AKXD16/TyJ | Repository-Cryopreserved |
| 001093 | AKXD18/TyJ | Repository-Cryopreserved |
| 001062 | AKXD21/TyJ | Repository-Cryopreserved |
| 000947 | AKXD22/TyJ | Repository-Cryopreserved |
| 000969 | AKXD24/TyJ | Repository-Cryopreserved |
| 000777 | AKXD6/TyJ | Repository-Cryopreserved |
| 000763 | AKXD9/TyJ | Repository-Cryopreserved |
| 000409 | B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ | Repository-Cryopreserved |
| 000418 | B10.129P-H1b Tyrc Hbbd/(5M)nSnJ | Repository-Cryopreserved |
| 000432 | B10.C-H1b Hbbd Tyrc/(41N)SnJ | Repository-Cryopreserved |
| 000822 | B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J | Repository-Cryopreserved |
| 000383 | B6.C-Tyrc H1b Hbbd/ByJ | Repository-Cryopreserved |
| 000619 | FS/EiJ | Repository-Cryopreserved |
| The FS/Ei strain was originally used as a linkage testing stock for gene mapping. It is homozygous for several visible recessive mutations including brown (Tyrp1b), pink-eyed dilution (Oca2p), chinchilla (Tyrc-ch), frizzy (fr), and the neurological mutation shaker 1 (Myo7ash1). It is also homozygous for a couple allelic variants that can be easily typed (Mod2b and Hbbd). Mice homozygous for the shaker 1 show circling, head-tossing, deafness, and hyperactivity characteristic of this type of mutant mice. Viability is normal, and breeding ability is high for a circling mutant. Homozygous mutant mice are most often deaf and swim well on the surface of water up to 4 weeks of age and more but lose the ability later. The degenerative changes of the labyrinth may occur a little later than in some of the other waltzing mutants. By light microscopy, the changes are seen to consist
..... For more information please see the full descriiption on the strain data sheet | ||
| 000494 | J.Cg-Oca2+ Tyr+ Lystbg/J | Repository-Cryopreserved |
| Mice homozygous for the beige spontaneous mutation (Lystbg) are characterized by a condition that closely resembles Chediak-Higashi disease in man and similar conditions in mink and cattle. Abnormal giant lysosomal granules occur in all tissues with granule-containing cells, including granulocytes, lymphocytes, cells of the liver, kidney, central nervous system, pancreas, and thyroid, and the ducts of most glands; in type II pneumocytes; in mast cells; and in retinal pigment epithelium. Granulocytes from beige homozygous mutant mice mice show defective chemotaxis and reduced bactericidal activity. Beige mice are more susceptible than controls to pneumonitis and to various viral, bacterial, and parasitic infections. Natural killer (NK) cells from beige mice exhibit decreased endogenous cytotoxic activity. Beige mice also have a defective cytotoxic T-cell and cytotoxic antibody response to allogeneic tumor cells. Syngeneic tumor cells grow better in beige mice than in l
..... For more information please see the full descriiption on the strain data sheet | ||
| 002281 | NFS.C58-Tyr+/J | Repository-Cryopreserved |
| 004304 | NOD.CBALs-Tyr+/LtJ | Repository-Cryopreserved |
| This Chr 7 congenic strain in which the tyrosinase allele Tyr+ of the CBA/JLsLt strain is fixed on the NOD/Lt background, therefore making the strain agouti in color. This strain should be a good donor for blastocysts in which to microinject targeted NOD ES cells, and may alleviate unwanted genome integration experienced with use of the C57BL/6 blastocysts. The congenic segment on Chr 7 slightly supresses spontaneous T1D development which is an asset when these females are used as blastocyst recipients. | ||
| 000271 | SH1/LeJ | Repository-Cryopreserved |
| Mice homozygous for the shaker 1 spontaneous mutation (Myo7ash1) show circling, head-tossing, deafness, and hyperactivity characteristic of this type of mutant mice. Viability is normal, and breeding ability is high for a circling mutant. Homozygous mutant mice are most often deaf and swim well on the surface of water up to 4 weeks of age and more but lose the ability later. The degenerative changes of the labyrinth may occur a little later than in some of the other waltzing mutants. By light microscopy, the changes are seen to consist of degeneration of the organ of Corti, the spiral ganglion, and the stria vascularis in the cochlea, and of the saccular macula and the vestibular ganglion in the vestibular labyrinth. | ||
| 001759 | STOCK A Tyrc Sha/J | Repository-Cryopreserved |
| 000006 | STOCK Hk Tyrc/J | Repository-Cryopreserved |
| While mice carrying the Hk mutation often have a hooked curl at the end of a shortened tail, this mutation may more consistently result in a displaced anus that is positioned posterior to the normal site and is more slit-shaped than circular. In some instances the anus has been located in the beginning of the tail and a depression was found to extend partway down the ventral side of the tail (Holman, 1951). The Hk mutation is semidominant with homozygotes often showing a shorter, more affected tail than heterozygotes (P.W. Lane Personal Communication). | ||
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