Search Criteria: Research Area is "Developmental Biology Research: Internal/Organ Defects (gonad, thyroid)"

JAX® Mice Strains

Stock
Number		 Strain Name
 
Strain Description		 Standard Supply
002494 B6;129S2-Cgatm1Sac/J
Repository-Cryopreserved
Mice homozygous for the Cgatm1Sac targeted mutation are viable but both sexes are infertile. They lack TSH, LH, and FSH. Homozygous mutant mice are hypogonadal and exhibit severe hypothyroidism resulting in dwarfism. Development of the thyroid gland was arrested in late gestation. However, gonadotropin releasing hormone (GNRH) neuron migration, development of secondary sex organs, and fetal and neonatal gonadal development are normal. Mice heterozygous for the Cgatm1Sac targeted mutation appear normal.

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