Search Criteria: Research Area is "Diabetes and Obesity Research: Type 2 Diabetes (NIDDM) (pre-type 2)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 002423 | NON/ShiLtJ | Level 3 |
| Although closely related to NOD mice, NON mice contain a diabetes resistant MHC haplotype (H2nb1 = Kb, Anb1, Ek, Db). The name was derived from "Non-Obese Non-diabetic"; however, NON/ShiLtJ mice should not be considered "normal." They carry the retinal degeneration (Pde6b) mutation and exhibit certain tendencies toward autoimmune disease. This strain maintains a low plasma insulin level, which may account in part why certain loci from NON/ShiLt can enhance development of autoimmune type 1 diabetes in segregating hybrid mice following outcross to NOD/ShiLtJ. The NON strain-characteristic immunologic abnormalities include perivascular/periductular leukocyte infiltration into the pancreas and submandibular salivary glands, and T lymphocytopenia evident by 20 weeks of age in spleen. NON/ShiLt mice clearly harbor genes predisposing to type 2 diabetes, as evidenced by early impaired glucose tolerance in males and females, d
..... For more information please see the full descriiption on the strain data sheet | ||
| 002111 | C3.SW/Lt-Chr YSW/J | Repository-Cryopreserved |
| C3.SW-H2b/SnJ (Stock number 000438) males exhibit maturity onset impairment of glucose tolerance and hyperinsulinemia. In contrast to Stock number 002110, this strain carries the C3.SW-H2b/SnJ Y chromosome. Males develop extreme hyperinsulinemia, transiently elevated plasma glucose and extreme islet hyperplasia. This strain and Stock number 002110 demonstrate that the Y chromosome modulates the level of hyperinsulinemic and glycemic stress exerted upon pancreatic beta cells. | ||
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