Search Criteria: Research Area is "Hematological Research: Hemoglobin Defects: thalassemia"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 008668 | 129S-Hba-a1tm1Led/J | Cryopreserved - Ready for recovery |
| Mice that are homozygous for the targeted mutation are viable and fertile, but are anemic. Reduced levels of gene product (mRNA) are detected by Northern blot analysis of homozygous embryos (due to compensatory expression of the α2-globin gene). Homozygous crosses yield smaller litters. Homozygotes exhibit increased platelet number, reduced hemoglobin concentration and mean corpuscular volume. Heterozygotes are viable, fertile, normal in size and exhibit an intermediary phenotype. This mutant mouse strain may be useful in studies of erythropoiesis, α-Thalassemia and hemoglobin defects. | ||
| 008667 | 129S-Hba-xtm1Led/J | Cryopreserved - Ready for recovery |
| Mice that are homozygous for this targeted mutation have an embryonic lethal phenotype. No gene product (mRNA) is detected by Northern blot analysis of homozygous embryos. α-globin mRNA expression is also reduced in homozygous embryos. Homozygous embryos (12 day pc) are anemic, pale, small in size, with peripheral blood anisocytosis, poikilocytosis, and polychromasia and reduced hemoglobin concentration and mean corpuscular volume. Heterozygotes are viable, fertile, and normal in size. Heterozygotes exhibit increased platelet number, and an intermediary phenotype of reduced hemoglobin concentration and mean corpuscular volume. This mutant mouse strain may be useful in studies of erythropoiesis, α-Thalassemia and hemoglobin defects. | ||
| 002204 | B6.129P2-Hbbtm1Unc/J | Cryopreserved - Ready for recovery |
| Mice homozygous for this mutation die perinatally due to severe anemia. | ||
| 002949 | B6.129S4-Klf1tm1Sho/J | Cryopreserved - Ready for recovery |
| Homozygotes die at embryonic day 15 due to severe anemia during erythropoiesis of the fetal liver. There is a defect in beta-globin expression in these mice. This strain may serve as a model for the human disease beta-thalassemia. | ||
| 007858 | B6.129S6(Cg)-Ahsptm1.1Mjwe/J | Cryopreserved - Ready for recovery |
| Mice homozygous for this targeted allele (AHSP-/- or ERAF-/-) are fertile with normal lifespans up to at least 18 months of age. No RNA or protein from the targeted gene is detected in hematopoietic tissues from homozygotes. AHSP-/- mice exhibit abnormal erythrocyte morphology with intracellular inclusion bodies that stain positively for denatured hemoglobin (Heinz bodies). Homozygous mice also have reduced lifespan of circulating red blood cells, increased apoptosis of erythroid precursors, and increased production of reactive oxygen species (ROS) with consequent damage to hemoglobin A and other cellular components. As the α-hemoglobin stabilizing protein specifically binds the cytotoxic free α-Hb subunit of hemoglobin A, these AHSP-mutant mice may be useful in studying erythroid development/erythropoiesis, thalassemia, Heinz body hemolytic anemia, and other hemoglobinopathies.
In an attempt to offer alleles on well-characterized or ..... | ||
| 001622 | B6.Cg-Gpi1a Hbath-J | Cryopreserved - Ready for recovery |
| 000996 | B6.D2-Hbbd3th/BrkJ | Cryopreserved - Ready for recovery |
| 002474 | B6;129S4-Klf1tm1Sho/J | Cryopreserved - Ready for recovery |
| Homozygotes die at embryonic day 15 due to severe anemia during erythropoiesis of the fetal liver. There is a defect in beta-globin expression in these mice. This strain may serve as a model for the human disease beta-thalassemia. | ||
| 002404 | STOCK Mostm1Ev/J | Cryopreserved - Ready for recovery |
| Mice homozygous for the Mostm1Ev targeted mutation are viable. Homozygous males are fertile; the littersize of homozygous females is markedly lower than that of wild type or heterozygous mice. Eggs lacking Mos undergo spontaneous parthenogenetic activation (extrusion of the second polar body and pronucleus formation without fertilization). Ovarian cysts develop in homozygous females as young as one month. Some of the ovarian cysts consist of several tissue types, including possible thyroid tissue, similar to about 10% of all benign cystic teratomas in human beings. | ||
| 000802 | WB.Cg-Hbath-J/J | Cryopreserved - Ready for recovery |
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