Search Criteria: Research Area is "Immunology and Inflammation Research: Immunodeficiency (MHC class I deficiency, hemochromatosis)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 002944 | B6.129S2-Tap1tm1Arp/J | Repository- Live |
| Mice homozygous mice for the Tap1tm1Arp targeted mutation are viable and fertile. They are defective in the stable assembly and intracellular transport of class I molecules. They show severely reduced levels of class I surface molecules. They lack CD4-8+ T cells. This phenotype is similar to the mouse RMA-S cell line and human beings with TAP1 and TAP2 deficiencies. This strain should be housed under pathogen free conditions similar to the Prkdcscid/Prkdcscid mouse or any other immunodeficient strain. | ||
| 002458 | B6;129S2-Tap1tm1Arp/J | Repository-Cryopreserved |
| Mice homozygous mice for the Tap1tm1Arp targeted mutation are viable and fertile. They are defective in the stable assembly and intracellular transport of class I molecules. They show severely reduced levels of class I surface molecules. They lack CD4-8+ T cells. This phenotype is similar to the mouse RMA-S cell line and human beings with TAP1 and TAP2 deficiencies. This strain should be housed under pathogen free conditions similar to the Prkdcscid/Prkdcscid mouse or any other immunodeficient strain. | ||
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