Search Criteria: Research Area is "Diabetes and Obesity Research: Pancreatic B Cell Adenomas"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 005109 | 129S(FVB)-Men1tm1.2Ctre/J | Repository-Cryopreserved |
| These mice possess loxP sites flanking exons 3 to 8 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When bred to a strain expressing Cre recombinase in pancreatic beta cells (see Stock No. 003573 for example), this mutant mouse strain may be useful in studies of pancreatic islet adenomas. | ||
| 004066 | FVB;129S-Men1tm1.1Ctre/J | Repository-Cryopreserved |
| Mice that are homozygous null for the Men1 gene die in utero at embryonic days 10.5-11.5, exhibiting delayed development often (20%) with defects in cranial/facial formation. At birth, heterozygous mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. At nine months, ~80% of the heterozygous-null mice develop abnormalities in pancreatic islet cells, the severity of which ranges from hyperplasia to insulin-producing tumors. Parathyroid adenomas are also observed at this age. Tumor incidence is progressive, with occurrences in multiple endocrine tissues (pancreatic islets, parathyroids, thyroid, adrenal cortex, pituitary) by sixteen months of age. | ||
| 002380 | NOD.Cg-Tg(Ins2-TAg)1Lt Prkdcscid/DvsJ | Repository-Cryopreserved |
| Homozygous NOD/Lt-TgN(RipTag)1Lt-Prkdcscid mice develop pancreatic beta cell adenomas. They are able to produce 2-3 litters before the insulin secreted from the adenoma makes them too hypoglycemic. Because Prkdcscid mice lack T-cells the adenomas from this strain are free of the autoimmune T-cells found in the adenomas of NOD/Lt-TgN(RipTag)1Lt mice. | ||
| 002033 | NOD/ShiLt-Tg(RipTAg)1Lt/J | Repository-Cryopreserved |
| Homozygous NOD/Lt-Tg(RipTag)1Lt mice develop pancreatic beta cell adenomas. They are able to produce 2-3 litters before the insulin secreted from the adenoma makes them too hypoglycemic. | ||
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