Search Criteria: Research Area is "Neurobiology Research: Astrocyte Defects (astrocytosis)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 003095 | B6.D2-ingls/J | Repository-Cryopreserved |
| Mice homozygous for the recessive ingls mutation are significantly smaller than their littermates, and their coat color is dilute with white underfur both dorsally and ventrally (Sweet 1991; Samples 2003). Most develop hydrocephalus with onset by one week of age. Homozygotes are weak and uncoordinated and have difficulty righting themselves. They fail to gain weight during the second week of life, and most die by three weeks of age. (Bronson et al. 2003) Length of survival appears to correlate with the severity of hydrocephalus, which varies from absent to severe; however, all homozygotes die by 4 weeks, whether or not they are hydrocephalic (Samples et al. 2003). Hydrocephalus affects the lateral ventricles most severely; serial sections reveal an intact cerebral aqueduct. Diffuse astrocytic hypertrophy and hyperplasia are observed in brains and spinal cords of mutant mice. A few mutants develop status spongiosis, and a few exhibit gliosis alone. Astrocytes cul
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