Search Criteria: Research Area is "Neurobiology Research: Behavioral and Learning Defects (Down syndrome)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 006410 | B6;129S6-Chattm1(cre)Lowl/J | Repository- Live |
| Homozygous mice maintained at The Jackson Laboratory are viable and fertile. An "IRES-Cre" sequence is inserted downstream of the stop codon such that cre expression is controlled by the endogenous Chat gene promoter. Chat gene expression, however, is unaffected. Cre recombinase activity is reported in all cholinergic neurons. These mice may be useful for "Cre-lox" technology applications in neurobiology, including studies of motor function, learning and memory, Alzheimer's disease, and Down syndrome, and in obesity and diabetes research. | ||
| 001924 | B6EiC3Sn a/A-Ts(1716)65Dn | Repository- Live |
| Segmentally trisomic Ts(1716)65Dn mice provide a postnatal model for Down syndrome. Ts65Dn mice have three copies of most of the genes on mouse Chr 16 that are homologues of human Chr 21 genes. These extra genes, along with the centromere and about 5% of proximal Chr 17 are contained in a small extra chromosome derived from a reciprocal translocation. Neural cognitive deficits and behavioral abnormalities have been noted in Ts65Dn mice. They have spatial learning and memory defects as assessed in the Morris water maze and the radial arm maze, show developmental delay in sensorimotor milestones, and exhibit locomotor hyperactivity, lack of behavioral inhibition, and stereotypic behavior. They perform similar to controls in visual placing, balance, prehensile reflex and traction on a horizontal bar, motor coordination, swimming ability, olfaction orienting. They also show altered noradrenergic transmission in the hippocampus and cerebral cortex and degeneration of basal forebr
..... For more information please see the full descriiption on the strain data sheet | ||
| 005654 | B6C3-Del(16Cbr1-ORF9)1Rhr/J | Repository-Cryopreserved |
| These mice are monosomic for the mouse chromosome segment MMU16. The deleted segment contains mouse orthologs of 33 conserved and minimally conserved genes in the human Down's syndrome critical region (DSCR). The borders of the deletion are defined by the carbonyl reductase 1 (Cbr1) gene and a site adjacent to the myxovirus (influenza virus) resistance 2 (Mx2) locus. Monosomic mice are viable, fertile and are significantly smaller than wildtype (euploid) littermates from birth to adulthood. This mouse may be useful in studies of Down syndrome and further exploring the ploidy of DSCR/MMU16. | ||
| 004850 | B6EiC3Sn-Rb(12.T171665Dn)2Cje/CjeDn | Repository-Cryopreserved |
| Like B6EiC3Sn a/A - Ts(1716)65Dn (Stock No. 001924), this strain has three copies of most of the genes on mouse Chromosome 16 that are homologues of human Chromosome 21 genes. Transmission of the chromosome 16 segmental trisomy through the female germline is significantly improved over Ts65Dn (43% versus 24%). Dendritic spines on granule cells in the fascia dentata are enlarged in size and decreased in density (Villar AJ, et al. 2005). Unlike Ts65Dn, males are fertile. Mice are 20% smaller in size than controls. This strain serves a model for Down syndrome. | ||
| 004861 | B6EiC3Sn-Ts(16C-tel)1Cje | Repository-Cryopreserved |
| Ts(16C-tel)1Cje trisomic mice display decreased exploratory behavior and have spatial learning deficits detectable in the hidden platform and probe versions of the Morris water maze. These learning deficits are less severe than those of mice carrying Ts(1716)Dn, a larger distal chromosome 16 translocation. The degeneration of basal forebrain cholinergic neurons that is found in Ts(1716)Dn carriers has not been found by six months of age in mice carrying Ts(16C-tel)1Cje. Additionally, the male sterility found in Ts(1716)Dn carriers is not a phenotype associated with Ts(16C-tel)1Cje. (Sago et al., 1998.) Despite having fewer trisomic genes, Ts(16C-tel)1Cje carriers display much of the same craniofacial dysmorphology as that found in Ts(1716)Dn, which includes brachycephaly, reduced interorbital breadth, and smaller mandible. (Richtsmeier et al., 2002.) | ||
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