Search Criteria: Research Area is "Neurobiology Research: Down syndrome"

New Strains Awaiting Transfer from the Donor
Additional Register Interest Strains

JAX® Mice Strains

Stock
Number
Strain Name
 
Strain Description
Standard Supply
013530 B6.129S7-Dp(16Lipi-Zfp295)1Yey/J
Repository- Live
It should be noted that the phenotype of these C57BL/6J-congenic Dp(16)1Yey/+ mice could vary from that originally described on a C57BL/6J;129S7/SvEvBrd genetic background. We may modify the strain description if necessary as published results become available. The phenotype of Dp(16)1Yey/+ mice on a C57BL/6J;129S7/SvEvBrd genetic background is described below:

This Dp(16)1Yey/+ mutant strain contains one copy of mouse Chromosome 16 with the targeted sequence between, and including, the lipase, member I (Lipi) gene and the zinc finger protein 295 (Zfp295) gene. Hemizygous mice are fertile. The donating investigator recently observed that 30% of offspring die shortly after birth due to heart defects. This duplicated region on the mouse chromosome is one of three regions orthologous to an extra copy of human Chromosome 21 (Hsa21) which has been implicated in developmental cognitive disabilities associated with Down Syndrome (DS). <> .....
For more information please see the full phenotype on the strain data sheet

010801 B6;129S-Tc(HSA21)1TybEmcf/J
Repository- Live
Mice carrying a human fragment of Chromosome 21 (Hsa21) are viable, fertile, and normal in size, only the female carriers consistently transmits the mutation to the germline. When maintained on a background other than (C57BL/6 X 129S8/SvEv) germline transmission is completely abolished. These Tc1 mice contain 42Mb (approximately 83%) of a freely segregating Hsa21 containing 269 genes, including most of the gene orthologues located on mouse Chromosome 10 (Mmu10), Mm16, and Mmu17, which have been found to contribute to human Down Syndrome (DS). This mouse strain represents the most complete model of DS, exhibiting alterations in behavior, learning, memory, synaptic plasticity, cerebellar neuronal number, heart development, mandible size, defects in motor coordination, perturbed haematopoiesis, and reduced tumour angiogenesis. These mice may be useful for studying the genes involved in human chromosome aneuploidy and its role in DS.
006410 B6;129S6-Chattm2(cre)Lowl/J
Repository- Live
Mice that are homozygous for the ChAT-IRES-Cre knockin are viable and fertile. An "IRES-Cre" sequence is inserted downstream of the stop codon such that cre expression is controlled by the endogenous Chat gene promoter. Chat gene expression, however, is unaffected. Cre recombinase activity is reported in all cholinergic neurons. These mice may be useful for "Cre-lox" technology applications in neurobiology, including studies of motor function, learning and memory, Alzheimer's disease, and Down syndrome, and in obesity and diabetes research.

View cre expression characterization.

001924 B6EiC3Sn a/A-Ts(1716)65Dn/J
Repository- Live
Segmentally trisomic Ts(1716)65Dn mice provide a postnatal model for Down syndrome. Ts65Dn mice have three copies of most of the genes on mouse Chr 16 that are homologues of human Chr 21 genes. These extra genes, along with the centromere and about 5% of proximal Chr 17 are contained in a small extra chromosome derived from a reciprocal translocation. See FISH chromosome spreads.

Neural cognitive deficits and behavioral abnormalities have been noted in Ts65Dn mice. They have spatial learning and memory defects as assessed in the Morris water maze and the radial arm maze, show developmental delay in sensorimotor milestones, and exhibit locomotor hyperactivity, lack of behavioral inhibition, and stereotypic behavior. They perform similar to controls in visual placing, balance, prehensile reflex and traction on a horizontal bar, motor coordination, swimming ability and olfaction orienting. They also show altered noradrene .....
For more information please see the full phenotype on the strain data sheet
004850 B6EiC3Sn-Rb(12.Ts171665Dn)2Cje/CjeDnJ
Repository- Live
The trisomic segment in the Rb(12.Ts171665Dn)2Cje strain is genetically identical to the Ts65Dn strains, Stock No. 001924 and Stock No. 005252, with trisomy of the Chr 16 genes, from Mrpl39 to the distal telomere. Quantitative PCR confirmed the triplication of Chr 16 genes from App to Mx1. Transmission of the chromosome 16 segmental trisomy through the female germline is significantly improved over Ts65Dn (43% versus 24%). Dendritic spines on granule cells in the fascia dentata are enlarged in size and decreased in density (Villar AJ, et al. 2005). Unlike Ts65Dn, males are fertile. Trisomic mice are 20% smaller in size than controls. This strain serves a model for Down syndrome.
005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ
Repository- Live
Segmentally trisomic Ts(1716)65Dn mice provide a postnatal model for Down syndrome. Ts65Dn mice have three copies of most of the genes on mouse Chr 16 that are orthologous to human Chr 21 genes. These extra genes, along with the centromere and about 5% of proximal mouse Chr 17 are contained in a small extra chromosome derived from a reciprocal translocation. See FISH chromosome spreads.

Trisomic mice with the wild-type allele of Pde6b, are similar to the B6EiC3Sn-a/A-Ts(1716)65Dn/J (Stock No. 001924) trisomic mice in that they display slightly shorter body length and lower body weight (see Ts65Dn mouse photograph), show reduced grip strength, nocturnal hyperactivity, and impaired performance in the Morris water maze. Any differences in the Morris water maze tests for the two genetic backgrou .....
For more information please see the full phenotype on the strain data sheet
018957 B6N.129S6(B6)-Chattm2(cre)Lowl/J
Repository- Live
To be more suitable for use with C57BL/6N-congenic Knockout Mouse Project (KOMP) strains with floxed alleles, The Jackson Laboratory Repository chose several Cre recombinase-expressing strains and backcrossed them onto the C57BL/6N genetic background using a marker-assisted, speed-congenic approach. This approach employed 148 single nucleotide polymorphism (SNP) markers that differ between the C57BL/6N and C57BL/6J substrains, covering all 19 chromosomes and the X chromosome. This analysis has determined that all SNP markers are now C57BL/6N allele-type (with the exception of 2 markers near the Chat locus on chromosome 14).

The parental line, C57BL/6;129S6 ChAT-IRES-Cre knockin mice, are available and described as Stock No. 006410. It should be noted that the phenotype of these C57BL/6NJ-congenic ChAT-IRES-Cre knockin mice (Stock No. 018957) could vary from that of the parental line from which it was derived. We may .....
For more information please see the full phenotype on the strain data sheet

024907 129-Del(16Tiam1-Il10rb)9Yey/J
Under Development - Now Accepting Orders
This Df(16)3Yey/+ mutant strain lacks a 2.11 Mb segment of mouse Chromosome 16. The sequence is defined by the T cell lymphoma invasion and metastasis 1 (Tiam1) gene and the interleukin 10 receptor, beta (Il10rb) gene. Hemizygous mice are fertile. This region is located in one of three mouse chromosome regions orthologous to an extra copy of human Chromosome 21 (Hsa21) implicated in heart defects and cognitive deficits associated with Down Syndrome (DS). Df(16)3Yey/+ contains 17 genes orthologous to genes on Hsa21. These mice do not exhibit the heart defects associated with Down syndrome.
024908 129-Dp(16Ifnar1-Kcnj6)10Yey/J
Under Development - Now Accepting Orders
This Dp(16)4Yey/+ mutant strain contains a duplicated segment of mouse Chromosome 16. The sequence is defined by the interferon (alpha and beta) receptor 1 (Ifnar1) gene and the potassium inwardly-rectifying channel, subfamily J, member 6 (Kcnj6) gene. Hemizygous mice are fertile. This duplicated region is located in one of three mouse chromosome regions orthologous to an extra copy of human Chromosome 21 (Hsa21) implicated in heart defects associated with Down Syndrome (DS). Dp(16)4Yey/+ contains 35 genes orthologous to genes on Hsa21, and thus decreases the minimal critical genomic region to 3.7 Mb on Chr 16. These mice exhibit heart defects including transposition of great arteries, atrioventricular defect, and double outlet right ventricle.
024906 129-Dp(16Tiam1-Il10rb)8Yey/J
Under Development - Now Accepting Orders
This Dp(16)3Yey/+ mutant strain contains a 2.11 Mb duplicated segment of mouse Chromosome 16. The sequence is defined by the T cell lymphoma invasion and metastasis 1 (Tiam1) gene and the interleukin 10 receptor, beta (Il10rb) gene. Hemizygous mice are fertile. This duplicated region is located on one of three mouse chromosome regions orthologous to an extra copy of human Chromosome 21 (Hsa21) implicated in heart defects and cognitive deficits associated with Down Syndrome (DS). Dp(16)3Yey/+ contains 17 genes orthologous to genes on Hsa21. These mice do not exhibit the heart defects associated with Down syndrome.
005383 B6.129S6-Dp(16Cbr1-ORF9)1Rhr/J
Cryopreserved - Ready for recovery
These mice are trisomic for the mouse chromosome segment orthologus to the human chromosome 21 Down syndrome critical region (DSCR). The borders of the 3.9 Mb region are defined by the carbonyl reductase 1 gene and a site adjacent to the myxovirus (influenza virus) resistance 2 locus. Trisomic mice are viable, fertile and are significantly larger than euploid littermates. Mandible size is enlarged as is skull size, with an overall elongation of the rostrocaudal aspect in comparison to euploid littermates. This mouse may be useful in studies exploring the consequences of polyploidy involving the DSCR.
013529 B6;129S7-Dp(10Prmt2-Pdxk)2Yey/J
Cryopreserved - Ready for recovery
This Dp(10)2Yey/+ mutant strain contains one copy of mouse Chromosome 10 with the targeted sequence duplicated between, and including, the protein arginine N-methyltransferase 2 (Prmt2) gene and the pyridoxal (pyridoxine, vitamin B6) kinase (Pdxk) gene. Hemizygous mice are viable and fertile. This duplicated region on the mouse chromosome is one of three regions orthologous to an extra copy of human Chromosome 21 (Hsa21) which has been implicated in developmental cognitive disabilities like Down Syndrome (DS). Dp(10)1Yey/+ contains a duplication syntenic to the distal part of human 21q22.3, and carries 41 genes orthologous to genes on Hsa21. When mice carrying this duplication are bred to B6;129-Dp(16Lipi-Zfp295)1Yey/J mice (Stock No. 013530) and B6;129-Dp(17Abcg1-Rrp1b)3Yey/J mice (Stock No. 013531) to create a triple duplication .....
For more information please see the full phenotype on the strain data sheet
013531 B6;129S7-Dp(17Abcg1-Rrp1b)3Yey/J
Cryopreserved - Ready for recovery
This Dp(17)3Yey/+ mutant strain contains one copy of mouse Chromosome 17 with the targeted sequence duplicated between, and including, the ATP-binding cassette, sub-family G (WHITE), member 1 (Abcg1) gene and ribosomal RNA processing 1 homolog B (S. cerevisiae) (Rrp1b) gene. Hemizygous mice are viable and fertile. This duplicated region on the mouse chromosome is one of three regions orthologous to an extra copy of human Chromosome 21 (Hsa21) which has been implicated in developmental cognitive disabilities associated with Down Syndrome (DS). Dp(17)1Yey/+ contains a duplication syntenic to the proximal part of human 21q22.3, and carries 19 genes orthologous to genes on Hsa21. When mice carrying this transgene are bred to B6;129-Dp(10Prmt2-Pdxk)2Yey/J mice (Stock No. 013529) and B6;129-Dp(16Lipi-Zfp295)1Yey/J mice (Stock No. 013530 .....
For more information please see the full phenotype on the strain data sheet
005654 B6C3-Del(16Cbr1-ORF9)1Rhr/J
Cryopreserved - Ready for recovery
These mice are monosomic for the mouse chromosome segment orthologous to the human chromosome 21 Down syndrome critical region (DSCR). The deleted segment contains mouse orthologs of 33 conserved and minimally conserved genes in the human DSCR. The borders of the deletion are defined by the carbonyl reductase 1 (Cbr1) gene and a site adjacent to the myxovirus (influenza virus) resistance 2 (Mx2) locus. Monosomic mice are viable, fertile and are significantly smaller than wildtype (euploid) littermates from birth to adulthood. This mouse may be useful in studies of Down syndrome and further exploring the ploidy of the DSCR segment of mouse Chr 16.
004861 B6EiC3Sn-Ts(16C-tel)1Cje/DnJ
Cryopreserved - Ready for recovery
Ts(16C-tel)1Cje trisomic mice display decreased exploratory behavior and have spatial learning deficits detectable in the hidden platform and probe versions of the Morris water maze. These learning deficits are less severe than those of mice carrying Ts(1716)Dn (Ts65Dn, Stock No. 001924 or 005252) with a larger distal Chr 16 translocation. The degeneration of basal forebrain cholinergic neurons that is found in Ts65Dn trisomic mice has not been found by six months of age in mice carrying Ts(16C-tel)1Cje. Additionally, the male sterility found in Ts65Dn mice is not a phenotype associated with Ts(16C-tel)1Cje (Sago et al., 1998). Despite having fewer trisomic genes, Ts(16C-tel)1Cje carriers display much of the same craniofacial dysmorphology as that found in Ts(1716)Dn, which includes brachycephaly, reduced interorbital breadth, and smaller mandible .....
For more information please see the full phenotype on the strain data sheet
017529 91-1 (Hsa21) mES cells
In Stock

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New Strains Awaiting Transfer from the Donor

(See informational text following listing of strains)
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Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.

View a Data sheet for New Strains Awaiting Transfer
Select the strain name to link to the strain data sheet.

Stock
Number
Strain Name
 
Strain Description
Standard Supply
019460C57BL/6-Tg(DYRK1A)36Wjs/J
Awaiting Transfer from the Donor
These DYRK1A transgenic mice represent a clinically relevant animal model for a variety of Down Syndrome features including mental retardation, Alzheimer's Disease-like brain pathology, and increased food intake.

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New Strains Awaiting Transfer from the Donor
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The Jackson Laboratory serves as a worldwide distributor and national repository for common and rare strains of inbred mice and mice carrying spontaneous mutations or induced mutations (i.e., transgenic, targeted/"knockout", or chemically induced mutations). At any one time, we have over 100 strains at various stages of development and colony expansion.

It is VERY IMPORTANT that you register interest in strains Awaiting Transfer. The anticipated demand for a strain enables us to determine effectively the distribution plan for each strain. Registering interest also provides benefits to you (including advance notification of pending availability). Whether a strain is made available from a live colony OR from our cryopreservation repository, you may want to consider the option of Dedicated Supply. To learn more about Dedicated Supply, go to Services.

Additional Register Interest Strains

Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.

View a Data sheet for a Strain
Select the strain name to link to the strain data sheet.

Stock
Number
Strain Name
 
Strain Description
Standard Supply
024909B6;129-Del(16Ifnar1-Kcnj6)11Yey/Dp(16Ifnar1-Kcnj6)10Yey/J
In Progress
Dp(16)4Yey/Df(16)4Yey mice contain both duplicated and deleted regions involving a 3.7 Mb segment on Chr 16 defined by the Ifnar1 and Kcnj6 genes. These mice may have applications in studies related to understanding the developmental heart defects associated with Down syndrome and Monosomy 21.

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It is VERY IMPORTANT that you Register Interest. The anticipated demand for a strain enables us to determine effectively the distribution plan for each strain.

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