Search Criteria: Research Area is "Neurobiology Research: Channel and Transporter Defects (calcium)"

New Strains Under Development

JAX^® Mice Strains

Stock Number	Strain Name   Strain Description	Standard Supply
001756	B6C3Fe a/a-Cacng2stg/J	Repository- Live
	Mice homozygous for the spontaneous mutation stargazer (Cacng2stg) are first recognizable at 14 days of age by their smaller body size and slightly ataxic gait. Female stargazer homozygous mutant mice are fertile, but most of the males are unable to breed. The mutation is named for the abnormal head movements resembling choreiform head tossing that is characteristic of these mice. The behavioral symptoms progressively worsen with age, but both males and females will live to over one year of age. Electrocorticographical recordings of stargazer mice reveal frequent, prolonged, generalized spike-wave cortical discharges with behavioral arrest. The abnormal brain wave patterns are similar to those seen in human beings with absence epilepsy. Waggler homozygotes (Cacng2stg-wag) manifest a less severe phenotype than stargazer homozygotes, but do display an ataxic gait and occasional seizures. In general, young stargazer mice are more healthy than waggler ho ..... For more information please see the full descriiption on the strain data sheet
001276	C3H/HeJ-Atp2b2dfw/J	Repository- Live
	Mice homozygous for the deaf waddler spontaneous mutation (Atp2b2dfw) are deaf, walk with a hesitant, wobbly gait, and bob their heads. Both sexes are fertile.
005783	B6.129P2-Cacna1ctm1Dgen/J	Repository-Cryopreserved
	This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
005780	B6.129P2-Cacna2d3tm1Dgen/J	Repository-Cryopreserved
	This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
005781	B6.129P2-Cacng3tm1Dgen/J	Repository-Cryopreserved
	This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
005782	B6.129P2-Cacng4tm1Dgen/J	Repository-Cryopreserved
	This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
000566	B6.Cg-Os +/+ Cacna1atg-la/J	Repository-Cryopreserved
	Mice homozygous for the leaner spontaneous mutation (Cacna1atg-la) begin to show ataxia, stiffness, and retarded motor activity by 8 to 10 days of age. Many homozygous mutant mice die by weaning age, but some survive, and females may even breed. Homozygous mutant adults are characterized by instability of the trunk and hypertonia of the trunk and limb muscles. Seizures have not been observed. The cerebellum is reduced in size, particularly in the anterior region. There is loss of granule cells beginning at 10 days of age and loss of Purkinje and Golgi cells beginning after 1 month. Leaner/tottering heterozygotes (Cacna1atg-la/Cacna1atg) show ataxia, stiffness, and retarded motor activity at 15 to 17 days of age. Within a few days, they develop a wobbly gait and intermittent focal seizures which continue throughout life. The cerebellum shows shrinkage and degenerative changes of the Purkinje cells.
000544	B6.D2-Cacna1atg/J	Repository-Cryopreserved
	Mice homozygous for the tottering spontaneous mutation (Cacna1atg) are characterized by a wobbly gait beginning at around 3 to 4 weeks of age and affecting, particularly, the hindquarters and by intermittent, spontaneous seizures. The seizures are of two kinds: i) Sudden arrests of movement (behavioral absence seizures) begin at about 3 weeks and are accompanied by abnormal bursts of bilaterally synchronous spike waves in ECG; they last about 0.3 to 10 seconds, occur hundreds of times per day, and continue throughout life; ii) Stereotyped partial motor seizures begin at about 4 weeks and are accompanied by abnormal ECG activity; they last 20 to 30 minutes, occur once or twice a day, and persist throughout life. Homozygous mutant mice of both sexes are fertile, but breeding performance is poor. Leaner/tottering heterozygotes (Cacna1atg-la/Cacna1atg) show ataxia, stiffness, and retarded motor activity at 15 to 17 days of age. Within a few ..... For more information please see the full descriiption on the strain data sheet
001883	B6.MRL-Cacng2stg-wag/J	Repository-Cryopreserved
003892	B6;BKS-Atp2b2dfw-3J/J	Repository-Cryopreserved
005050	B6;CByJ-Cacna2d2du-3J/J	Repository-Cryopreserved
	View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page for nmf299 entry.
000504	B6EiC3Sn a/A-Cacnb4lh/J	Repository-Cryopreserved
	Mice homozygous for the lethargic spontaneous mutation (Cacnb4lh) are first recognizable at 15 days by their lethargic behavior with gait instability and occasional seizures. The seizures resemble human petit mal seizures. No pathological changes were found in the CNS or in skeletal muscles, but peripheral motor nerves show reduced conduction velocity and prolonged distal latency. There is early thymic involution at 3 to 4 weeks in Cacnb4lh homozygotes, accompanied by decreased lymphocyte count, decreased cell-mediated immunity, and increased levels of serum IgG1. The defects in the immune system tend to disappear by 2 months of age in mice that survive. In addition to neurological and immunological defects, homozygous lethargic mice show pituitary-adrenal hypercorticism. Homozygotes are smaller and weaker than their normal littermates and often die before 2 months old. Survivors of both sexes may breed, but their reproductivity is low.
002894	CByJ.A-Atp2b2dfw-2J/J	Repository-Cryopreserved
	The deaf waddler 2J allele (Atp2b2dfw-2J) arose spontaneously in a congenic substrain of BALB/cByJ mice, CByJ.A-fsn/J. Homozygous mutant mice are viable, but neither sex will breed. They are recognizable by 12-14 days of age by their hesitant, wobbly gait and head bobbing behavior. Homozygotes also develop a slight body tremor and become increasingly lethargic. Homozygous mutant mice are profoundly deaf, exhibiting no discernible auditory brainstem responses (ABR) to stimuli up to 100 dB. Heterozygous Atp2b2dfw-2J mutant mice also show age-dependent changes in ABR and progressive hearing loss as a result of a modifier allele (ahl) present in BALB/cByJ mice. We are currently selecting away from the flaky skin mutation (fsn) carried by this strain.

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New Strains Under Development

(See informational text following listing of strains)

How to Register Interest
Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.

View a Data sheet for New Strains Under Development
Select the strain name to link to the strain data sheet.

	Stock Number	Strain Name   Strain Description	Standard Supply
	008623	B10(Cg)-Cacna1aTg-5J/LetJ	Under Development for Cryo
	Mice heterozygous for the semi-dominant Tottering 5 Jackson mutation exhibit a shaky gait with hind limbs splayed laterally from the body in contrast to the other tottering mutants . Also, unlike tottering mice, Tg-5J heterozygotes do not exhibit dyskinesia or absence seizures. Axonal swelling is observed in Purkinje cells from homozygotes as well as a decrease in branching. The Tg-5J mutation causes a shift in voltage activation and inactivation to lower voltages. This strain may be useful for studies of epilepsy and voltage-dependent calcium channels. The C57BL/10J background appears to be embryonic lethal as no homozygotes are produced in heterozygote x heterozygote matings. On a mixed BALB/cByJ and C57BL/10J background some homozygotes are produced, but die before 6 weeks of age.
	008622	B6.C3Bir-Cacna1atg-4J/LetJ	Under Development for Cryo
	Homozygotes for the tottering 4 Jackson allele exhibit a phenotype similar to that of mice homozygous for the tottering allele. Mice have an ataxic gait, with high stepping, waggling movements and paroxysomal dyskinesia. EEG recordings reveal 5-7 Hz spike wave discharges accompanied by behavioral arrest lasting up to 1.8 sec and ocurring an average of four times per hour. This seizure phenotype is less severe than in tottering mice. Unique among the tottering alleles, tg-4J causes altered activation and inactivation kinetics of the voltage-dependent calcium channel. This strain may be useful for studies of epilepsy and voltage-dependent calcium channels.
	008625	C57BLKS/J-Cacna2d2du-2J/LetJ	Under Development for Cryo
	Mice homozygous for ducky-2J mutation exhibit ataxia and paroxysomal dyskinesia, however, they lack the "ducky" gait found in mice homozygous for the ducky allele (du) . EEG recordings reveal infrequent bilateral spike wave discharges accompanied by behavioral arrest. Absence seizures are increased in comparison to ducky mice (personal communication). This strain may be useful for studies of epilepsy and voltage-dependent calcium channels.
	008626	STOCK Cacnb4lh-2J/LetJ	Under Development for Cryo
	Mice homozygous for the spontaneous mutation lethargic 2J have a similar phenotype to lethargic mice (See 000504). They exhibit lethargic behavior with gait instability and the occasional seizure. The molecular mutation is unknown, however, no CACNB4 protein product is detected by Western blot.

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New Strains Under Development

• Receive periodic updates on the status of the colony UNDER DEVELOPMENT
• Obtain advance notification of strain availability and opportunity to order prior to the strain being published as available
• Provide input affecting speed and quantity of availability

The Jackson Laboratory serves as a worldwide distributor and national repository for common and rare strains of inbred mice and mice carrying spontaneous mutations or induced mutations (i.e., transgenic, targeted/"knockout", or chemically induced mutations). At any one time, we have over 100 strains at various stages of development and colony expansion. Strains "Under Development" fall into two categories depending on the anticipated demand from the scientific community.

1. Strains that will be made available from a live distribution colony at The Jackson Laboratory.
   These strains are designated as: "Under Development for Distribution Colony"
2. Strains that will be made available through the Cryopreservation Repository.
   These strains are designated as: "Under Development for Cryopreservation Repository"

It is VERY IMPORTANT that you register interest in strains Under Development. The anticipated demand for a strain enables us to determine effectively the distribution plan for each strain Under Development. Registering interest also provides benefits to you (including advance notification of pending availability). Whether a strain is made available from a live colony OR from our cryopreservation repository, you may want to consider the option of Dedicated Supply. To learn more about Dedicated Supply, go to Services.

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