Search Criteria: Research Area is "Neurobiology Research: Channel and Transporter Defects (chloride: glycine receptor)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 005816 | B6.129P2-Glra3tm1Dgen/J | Repository-Cryopreserved |
| This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen. | ||
| 000066 | B6.Cg-Glrbspa/J | Repository-Cryopreserved |
| Mice homozygous for the spastic spontaneous mutation (Glrbspa) can usually be recognized at 14 days of age but sometimes not until 5 or 6 weeks. They show spastic symptoms which sometimes occur spontaneously and can always be induced by handling. The spasms consist of rapid tremor, stiffness of posture, and difficulty in righting when placed on the back. No anatomical pathology occurs in either muscle or CNS except that herniated intervertebral discs and cysts of the leptomeninges occur, most severely in the lumbar region, possibly as a result of traumatic injuries consequent on spasticity and tremor. The spastic symptoms can be markedly alleviated by intraperitoneal injection of aminooxyacetic acid, an inhibitor of g-aminobutyric acid transaminase (GABA-T), but not by Dilantin or trimethadione. There is a decrease to less than 20% of normal in the receptor for glycine, the major inhibitory neurotransmitter in the spinal cord and brainstem. | ||
| 001278 | B6C3Fe a/a-Glra1spd/J | Repository-Cryopreserved |
| Mice homozygous for the spasmodic spontaneous mutation (Glra1spd) have rapid tremors, stiff posture, and difficulty in righting themselves. No differences have been observed in the levels of major CNS or PNS myelin proteins or lipids. As with the spastic mutation (Glrbspa) of the mouse, aminooxyacetic acid improves the behavioral abnormalities in spasmodic mice, but, unlike in spastic mice, no changes in the postsynaptic receptors for glycine, GABA, or benzodiazepines have been observed. | ||
| 000241 | B6C3Fe a/a-Glrbspa/J | Repository-Cryopreserved |
| Mice homozygous for the spastic spontaneous mutation (Glrbspa) can usually be recognized at 14 days of age, but some mutant mice may not be reliably distinguished until 5 or 6 weeks of age. They show spastic symptoms in response to handling, but spastic behavior can occur spontaneously. The spasms consist of rapid tremor, stiffness of posture, and difficulty in righting when placed on the back. No anatomical pathology occurs in either muscle or the central nervous system, except that herniated intervertebral discs and cysts of the leptomeninges occur, most severely in the lumbar region, possibly resulting from traumatic injuries sustained during the myoclonic episodes. The spastic symptoms can be markedly alleviated by intraperitoneal injection of aminooxyacetic acid, an inhibitor of g-aminobutyric acid transaminase (GABA-T), but not by Dilantin or trimethadione. Glycine receptor expression in the CNS of spastic mice is reduced to 20%, or less, of normal. | ||
| 000536 | C57BL/6J-Glra1spd-ot/J | Repository-Cryopreserved |
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