Search Criteria: Research Area is "Neurobiology Research: Channel and Transporter Defects (sodium)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 005837 | B6.129P2-Scn11atm1Dgen/J | Repository-Cryopreserved |
| This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen. | ||
| 005836 | B6.129P2-Scn9atm1Dgen/J | Repository-Cryopreserved |
| This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen. | ||
| 003799 | B6.D2-Scn8amed-jo/J | Repository-Cryopreserved |
| 000304 | B6C3Fe a/a-Krt71Ca Scn8amed-J/J | Repository-Cryopreserved |
| Mice homozygous for the motor end plate disease-Jackson spontaneous mutation (Scn8amed-J) have a phenotype that resembles the original mutation (Scn8amed). Homozygous motor end plate disease mutant mice show progressive skeletal muscle weakness beginning 8 to 10 days postnatally and usually die within 2 weeks of onset. Other disease characteristics include progressive atrophy of skeletal muscle, marked terminal sprouting of motor nerves along with slower conduction velocity and prolonged refraction, and eventually failure of muscle fibers to show end-plate potentials or action potentials in response to nerve stimulation. Heterozygotes may show mild manifestations of the disease during the first 2 weeks of life but symptoms disappear with age. Both homozygotes and heterozygotes exhibit immunological aberrations. | ||
| 003798 | C3Fe.Cg-Scn8amed/J | Repository-Cryopreserved |
| 004102 | C57BL/6J-Scn8a4J/J | Repository-Cryopreserved |
| View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page for Scn8a4J entry. | ||
| 004105 | C57BL/6J-Scn8a5J/J | Repository-Cryopreserved |
| View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page for Scn8a5J entry. | ||
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