Search Criteria: Research Area is "Neurobiology Research: Vestibular and Hearing Defects (deafness, neurosensory 3)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 004406 | C3HeB/FeJ-Pou3f4del-J/J | Repository- Live |
| 004234 | B6;129S-Fgfr3tm1Dor/J | Repository-Cryopreserved |
| Approximately 50% of mice that are homozygous for the Fgfr3tm1Dor targeted mutation die between birth and 21 days of age. Surviving pups may live as long as 8 months. RNAase protection analysis of adult homozygous brain tissue indicates that an abnormal transcript may be generated, but that no functional protein results. Severe skeletal defects (kyphosis, scoliosis, crooked tails, curvature and overgrowth of long bones) are evident. Inner ear defects (lack of pillar cell differentiation and tunnel of Corti formation) resulting in profound deafness are also observed. | ||
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