Search Criteria: Research Area is "Sensorineural Research: Cataracts (AIDS research tool)"

JAX^® Mice Strains

Stock Number	Strain Name   Strain Description	Standard Supply
002456	FVB/N-Tg(CryHIVPR)72Gjj/J	Repository-Cryopreserved
	Mice homozygous for the expression of HIV-1 protease (HIVPr) linked to the lens alphaA-crystallin promoter are viable and fertile. Homozygotes develop bilateral cataracts at 23 - 24 days of age, beginning in the perinuclear region of the lens. Proteolysis begins with the loss of betaB1-, betaB3- and betaA3-crystallins and the appearance of crystallin fragments, accompanied by protein leakage and breakdown of cytoskeletal elements. It appears that the HIV-1 protease works in concert with other endogenous proteases to induce the changes that eventually result in opacification of the lens.

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