Search Criteria: Research Area is "Sensorineural Research: Cataracts (lens extrusion)"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 005043 | B6;129-nmf166/J | Repository-Cryopreserved |
| Mice homozygous for the nmf166 mutation have lens extrusion cataracts and deep anterior chambers at 12 weeks of age. View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page for nmf166 entry. | ||
| 001490 | C;AK-Gja8Lop10/J | Repository-Cryopreserved |
| The lens opacity 10 mutation in Gja8 is semidominant. Homozygotes are microphthalmic with foamy cataract of the entire lens apparent when the eyes open at 12 days of age and increasing in opaqueness with age. Bladder cells are found adjacent to the anterior and posterior subcapsular regions of the lens before birth, the lens nucleus begins to liquefy by 4 days of age and ruptures posteriorly, then the lens capsule thickens. Gja8Lop10 Heterozygotes are not microphthalmic and the phenotype associated with the mutation varies according to the genetic background. A nuclear haze or snowflake nuclear opacity is found in F1 heterozygotes of some backgrounds while a more severe dense nuclear opacity is evident by 4 weeks of age in F1 heterozygotes of other backgrounds including AKR/J and BALB/cJ. Mice homozygous for the Gja8tm1Paul targeted mutation, a recessive mutation in which the entire coding region is removed, do not display posterior lens r
..... For more information please see the full descriiption on the strain data sheet | ||
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