Search Criteria: Research Area is "Reproductive Biology Research: Gonadal Tumors (granulosa cell tumors)"

Strains from the Research Colonies of Jackson Laboratory Scientists
New Strains Under Development

JAX^® Mice Strains

Stock Number	Strain Name   Strain Description	Standard Supply
003911	SWR.SJL-(DXMit210-DXMit38)/BmJ	Repository-Cryopreserved

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Strains from the Research Colonies of Jackson Laboratory Scientists

IMPORTANT NOTE: Price information is on the strain data sheet which can be viewed by clicking on the strain name.

Stock Number	Strain Name   Strain Description	Standard Supply
001079	SWXJ9/BmJ	Research Strain
	SWXJ-9 female mice develop ovarian granulosa cell carcinomas with an incidence of approximately 12% and a latency of 4-6 weeks. Tumor incidence can be increased to approximately 40% by treatment with dehydroepiandrosterone (DHEA) or testosterone immediately after weaning. Treatment with estradiol during this period completely suppresses tumorigenesis. Neoplasias are first observed as hemorrhagic follicles in which the antrum is blood-filled and lined with irregular masses of proliferating granulosa cells. By 6-10 weeks of age, the primary tumor encompasses the entire ovary. Metastases to lung, renal node, and liver are common by 6 to 9 months of age, with other sites occasionally affected. Susceptibility to granulosa cell carcinomas is controlled by a small number of genes, including a major susceptibility locus on Chromosome 4 and a major modifier locus on the X chromosome.

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New Strains Under Development

(See informational text following listing of strains)

How to Register Interest
Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.

View a Data sheet for New Strains Under Development
Select the strain name to link to the strain data sheet.

	Stock Number	Strain Name   Strain Description	Standard Supply
	002105	NZO/HlLtJ	On Hold
	NZO mice of both sexes exhibit high birth weights and are significantly heavier at weaning age, Severe obesity (including both visceral and subcuatneous fat depots) develops even when mice are maintained on a standard diet containing 4.5% fat. Both males and females of the NZO/Hl substrain exhibit impaired glucose tolerance (IGT), but subsequent type 2 maturity onset (NIDDM) diabetes development is limited to males, with a phenotype penetrance of 50% or less. NZO/Hl mice also show anti-insulin receptor antibodies, a defect in leptin transport, and hypertension. The genetic lesion appears to be within the islets of Langerhans as transfer of pancreatic islets from normal mice returns body weights and blood glucose levels to within normal range. Ovarian granulosa cell tumors, lymphomas, duodenal, and lung tumors have also been noted to occur in NZO mice at an elevated frequency. F1 hybrids of NON/ShiLt and NZO/Hl provide a new model of obesity-induced diabetes. Male (NON/ShiLt x NZO/Hl)F1 ..... For more information please see the full description on the strain data sheet

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New Strains Under Development

• Receive periodic updates on the status of the colony UNDER DEVELOPMENT
• Obtain advance notification of strain availability and opportunity to order prior to the strain being published as available
• Provide input affecting speed and quantity of availability

The Jackson Laboratory serves as a worldwide distributor and national repository for common and rare strains of inbred mice and mice carrying spontaneous mutations or induced mutations (i.e., transgenic, targeted/"knockout", or chemically induced mutations). At any one time, we have over 100 strains at various stages of development and colony expansion. Strains "Under Development" fall into two categories depending on the anticipated demand from the scientific community.

1. Strains that will be made available from a live distribution colony at The Jackson Laboratory.
   These strains are designated as: "Under Development for Distribution Colony"
2. Strains that will be made available through the Cryopreservation Repository.
   These strains are designated as: "Under Development for Cryopreservation Repository"

It is VERY IMPORTANT that you register interest in strains Under Development. The anticipated demand for a strain enables us to determine effectively the distribution plan for each strain Under Development. Registering interest also provides benefits to you (including advance notification of pending availability). Whether a strain is made available from a live colony OR from our cryopreservation repository, you may want to consider the option of Dedicated Supply. To learn more about Dedicated Supply, go to Services.

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Send questions to our Technical Support team using the Express Technical Support Form.
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