Search Criteria: Research Area is "Reproductive Biology Research: Prostate Tumors"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 008215 | (C57BL/6-Tg(TRAMP)8247Ng/J x FVB/NJ)F1/J | Repository- Live |
| Mice carrying the TRAMP (Transgenic Adenocarcinoma of Mouse Prostate) transgene develop progressive forms of prostate cancer with distant site metastasis, primarily to the lymph nodes and lungs. These transgenic mice express the simian virus 40 (SV40) large tumor T antigen (Tag) under the control of the rat probasin promoter. Expression of the transgene is specific to the prostate epithelium. Transgenic mice exhibit various forms of disease from mild intraepithelial hyperplasia to large multinodular malignant neoplasia. The median survival time for these F1 transgenic mice is 19 weeks, very few mice survive past 33 weeks of age, which is significantly shorter than the lifespan of transgenic mice on the C57BL/6 background. Comparative histological analysis of tumors from these F1 transgenic mice and from transgenic mice on the C57BL/6 background reveals that the tumors found in these F1 mutants arise from the dorsolateral and ventral lobes of the prostate and are more spherical, hig ..... For more information please see the full phenotype on the strain data sheet | ||
| 003135 | C57BL/6-Tg(TRAMP)8247Ng/J | Repository- Live |
| These mice harbor the Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP); PB-Tag Line 8247 transgene. Mice hemizygous for the TRAMP transgene develop progressive forms of prostate cancer with distant site metastasis and exhibit various forms of disease from mild intraepithelial hyperplasia to large multinodular malignant neoplasia. TRAMP hemizygotes can exhibit prostatic epithelial neoplasia (PIN) by 12 weeks of age. Tumors, appearing as well differentiated adenocarcinoma, can arise by 24 weeks of age, mostly in the dorsal and lateral lobes of the prostate. By 30 weeks of age, most hemizygous mice will display evidence of metastatic spread to the lymph nodes and/or lungs, phylloides appearance of some tumors, and seminal vesicle invasion. Tumors exhibit elevated levels of nuclear TRP53 and decreased androgen receptor expression. Note that pure C57BL/6 TRAMP hemizygotes may live to 52 weeks of age or longer.
TRAMP mice are also available on a mixed C57BL/6 x FVB/N genet ..... | ||
| 013591 | FVB-Tg(C3-1-TAg)cJeg/JegJ | Repository- Live |
| Male transgenic mice develop prostatic hyperplasia in early life that progresses to adenoma or adenocarcinoma in about half of the animals which survive longer 7 months of age. Female animals generally develop mammary intraepithelial neoplasia with similarities to DCIS by 3 months of age with subsequent development of mammary adenocarcinoma by 6 months of age in 100% of the animals. About 10 - 15% of female mice develop lung metastases, although lung metastases from prostate cancer is extremely rare. Bone metastases have not been observed. The phenotype for this transgene has been most extensively studied in the FVB/N background. | ||
| 010930 | B6;CB-Tg(Pbsn-Hpn,-GFP)DVv/J | Cryopreserved - Ready for recovery |
| Hemizygous mice are viable and express mouse hepsin (Hpn) and humanized Renilla Green Fluorescent Protein under the control of the rat probasin promoter. Tissues in the transgenic animals show GFP fluorescence patterns consistent with the hepsin transgene expression, specifically in the ventral lobe of the prostate. Immunofluorescence staining with antibodies specific to basement membrane, histological and electron microscopical examination suggest that the basement membrane in the prostate gland is severely compromised. This mutant mouse strain may be useful in studies of prostate carcinogenesis and metastasis. When crossed with mice carrying the LBP-Tag line 12T-7f, Tg(Pbsn-Tag)12T7fRjm transgene (Kasper S et al., Lab Invest. 1998 Jun;78(6):i-xv), 20% of the resulting double transgenic mice (at 21 weeks of age) develop prostate cancer metastasis in liver, lung and bone. | ||
| 010929 | STOCK Tg(Pbsn-ERG*)1Vv/J | Cryopreserved - Ready for recovery |
| Mice that are hemizygous for this transgene are viable and normal in size and express the human avian erythroblastosis virus E-26 (v-ets) oncogene related (ERG) in prostate epithelium. By 5 to 6 months of age, male hemizygotes begin to exhibit prostatic intraepithelial neoplasia (PIN) in the ventral prostate. Although few cells have prominent nuclei, the percentage of cells with nucleomegaly increases with age. Luminal cells in the prostate epithelium accumulate and displace basal cells from the stromal compartment, but do not progress to invasive prostate cancer. This mutant mouse strain may be useful in studies of prostate carcinogenesis. | ||
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