Search Criteria: Research Area is "Mouse/Human Gene Homologs: albinism, tyrosine negative"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 000058 | B6(Cg)-Tyrc-2J/J | Level 2 |
| Mice homozygous for Tyrc-2J are phenotypically identical to homozygotes for the classic albino allele. Pigment is completely absent from skin, hair and eyes. While Tyr mRNA levels of Tyrc-2J homozygotes are similar to those of wild-type mice, there is virtually no tyrosinase protein present (Le Fur et al. 1996). Both homozygote and heterozygote mice are highly resistant to light damage and exhibit retinal degeneration (increased photoreceptor death) into young adulthood. Degeneration does not continue in adult mice (Bravo-Nuevo et al. 2004). | ||
| 000899 | C.B6-Tyr+ Hbbs/J | Repository- Live |
| 004624 | FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J | Repository- Live |
| Hemizygous male and homozygous female mice for this knockout show many phenotypic characteristics of the Fragile X Syndrome in humans that lack the fragile X mental retardation protein (FMRP) as a result of a mutation in the FMR1 gene. FMRP is an RNA binding protein whose function is shown to be involved in translational regulation of specific dendritic mRNAs. Certain regions of the brain in these mice are characterized by the presence of long, thin dendritic spines on excitatory neurons. Behavioral traits include deficits in classical delay eye-blink conditioning, autistic-like core symptoms of altered social interaction and occurrence of repetitive behaviors with additional hyperactivity, reduced anxiety, and increased errors in a learning assay. Whole-cell patch-clamp recordings in the anterior cingulate cortex show that long-term potentiation is completely abolished. A similar decrease in long-term potentiation is found in the la ..... For more information please see the full phenotype on the strain data sheet | ||
| 004828 | FVB.129P2-Pde6b+ Tyrc-ch/AntJ | Repository- Live |
| These mice are homozygous for the 129P2/OlaHsd wildtype Pde6b allele and do not suffer from blindness due to retinal degeneration. Mice from the colony of FVB.129P2-Fmr1tm1Cgr/J, Stock No. 004624, that no longer carried the mutant allele for Fmr1 were used to establish this line. Mice are pigmented as a result of the homozygosity of the Tyrc-ch allele. This mutant mouse strain may be useful in studies where a sighted mouse on the FVB background is an appropriate control, such as behavioral studies. | ||
| 017614 | B6(Cg)-Tyrc-2J Tg(UBC-mCherry)1Phbs/J | Under Development - Now Accepting Orders |
| These transgenic mice express monomeric red fluorescent protein (mCherry) under the direction of the human ubiqutin C promoter. Mice hemizygous for the transgene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These mice express mCherry in almost all tissues examined including pre- and post-implantation stage embryos, neonatal pups and adult mice. mCherry is strongly expressed in brain, testis, bladder, prostate and epipdymis and at lower levels in other tissues. No expression is detected in erythrocytes or thrombocytes. These mice may be useful as a bright and photostable means for visualizing morphogenesis and tissue rearrangements alone or in combination with mice expressing eGFP. | ||
| 014173 | STOCK Tyrc-2J Omptm1.1(COP4*/EYFP)Tboz/J | Under Development - Now Accepting Orders |
| These OMP-ChR2-YFP (OCY-58) mice express a ChR2(H134R)-EYFP fusion gene from the olfactory marker protein locus (Omp). Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. ChR2(H134R)-EYFP is expressed in all mature olfactory sensory neurons, rendering them light sensitive. Light directed at the olfactory epithelium or the glomeruli can elicit activity in mitral/tufted (M/T) cells of the olfactory bulb and can drive odor guided behavior. These mutant mice thus allow precise, timed delivery of stimuli input to the olfactory system. The Donating Investigator reports that this this targeted mutation creates a null allele. Due to possible olfactory deficits, analysis should be performed in heterozygous mice. The Donating Investigator recommends keeping the strain on the albino B6 background to avoid possible interference by pigmented melanocytes.
The ChR2(H134R)-EYFP fusio ..... | ||
| 000090 | 129S1/Sv-Oca2+ Tyr+ KitlSl-J/J | Cryopreserved - Ready for recovery |
| The multiple steel mutations (KitlSl) behave in a semidominant fashion and cause deficiencies in pigment cells, germ cells, and blood cells paralleling those caused by the Kit locus mutations (dominant spotting alleles). Most of the alleles at steel locus cause severe anemia in utero and death by 15 to 16 days of gestation in homozygous mutant mice. However, compounds of two steel mutants (e.g. KitlSl/KitlSl-d) are viable, black-eyed white, are usually sterile in one or both sexes, and have severe macrocytic anemia. Heterozygous steel mice have a diluted coat color with a small amount of white spotting, are viable and fertile, and may have a slight macrocytic anemia. Primordial germ cells are absent in the nonviable steel homozygotes and severely reduced in steel heterozygotes. Mast cells are virtually absent in skin and other tissues of steel mutant mice. Tumors tend to develop in germ-cell-deficient ovaries with advancing a ..... For more information please see the full phenotype on the strain data sheet | ||
| 000091 | 129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J | Cryopreserved - Ready for recovery |
| 005445 | A.B6 Tyr+-Cybanmf333/J | Cryopreserved - Ready for recovery |
| These mutants were detected through routine inspections for overt abnormal behavior; head- and body tilt can be observed at approximately 4 weeks of age (average onset 4.6 +/- 0.6 weeks; n=15). Standard pathology work-up and a whole-mount ear exam on one mutant (56 days of age) revealed no abnormalities. Male or female mutants have been produced and the colony is maintained through regular breeding.
View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page for nmf333 entry. | ||
| 005012 | A.B6 Tyr+-Myo5ad-l31J/J | Cryopreserved - Ready for recovery |
| The mutants are small with impaired hind limb movement, i.e. 'hot-foot' like behavior (of one or both limbs), and show agouti dilute coat color. These mice are fragile and usually die by or before 5 weeks of age; a colony needs to be maintained through ovarian transplants. Complementation tests between heterozygous NMF244 and DLS/LeJ mice produced six affected mice in a total of 22 progeny, suggesting that NMF244 represents a new allele of dilute-lethal in the Myo5a gene. These affected mice show a more severe phenotype than NMF244, i.e. they intermittently lean to the side, fall over, but are able to regain their walking position; they also show a non-agouti grey coat color. The coat color appears to result from a non-agouti grey allele that is known to exist in heterozygotes for the dilute-lethal allele of Myo5a, and becomes apparent in the presence of the agouti dilute allele, carried by the female NMF244. Standard pathology work-up on three mutants (23 - 29 days of age) reveale ..... For more information please see the full phenotype on the strain data sheet | ||
| 002565 | A.B6-Tyr+/J | Cryopreserved - Ready for recovery |
| 001017 | AKXD10/TyJ | Cryopreserved - Ready for recovery |
| 000765 | AKXD13/TyJ | Cryopreserved - Ready for recovery |
| 000954 | AKXD15/TyJ | Cryopreserved - Ready for recovery |
| 000958 | AKXD16/TyJ | Cryopreserved - Ready for recovery |
| 001093 | AKXD18/TyJ | Cryopreserved - Ready for recovery |
| 001062 | AKXD21/TyJ | Cryopreserved - Ready for recovery |
| 000947 | AKXD22/TyJ | Cryopreserved - Ready for recovery |
| 000969 | AKXD24/TyJ | Cryopreserved - Ready for recovery |
| 000777 | AKXD6/TyJ | Cryopreserved - Ready for recovery |
| 000763 | AKXD9/TyJ | Cryopreserved - Ready for recovery |
| 000409 | B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ | Cryopreserved - Ready for recovery |
| 000418 | B10.129P-H1b Tyrc Hbbd/(5M)nSnJ | Cryopreserved - Ready for recovery |
| 000432 | B10.C-H1b Hbbd Tyrc/(41N)SnJ | Cryopreserved - Ready for recovery |
| 000580 | B10.D2/nSn-Tyrc-4J/J | Cryopreserved - Ready for recovery |
| 000822 | B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J | Cryopreserved - Ready for recovery |
| 000578 | B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J | Cryopreserved - Ready for recovery |
| Mice homozygous for the Snell's waltzer spontaneous mutation (Myo6sv) show to a marked degree the typical circling, head-tossing, deafness, and hyperactivity of other mutant mice of this type. Homozygous mutant mice are recognizable by the age of 1 week. The abnormalities of the inner ear consist of degeneration of the entire neuroepithelium comprising the organ of Corti, the saccular and utricular maculae, and the cristae of all three semicircular canals. Although viability of homozygotes is nearly normal, breeding ability is reduced and males are more reliable breeders than females.
Specific cytoskeletal components are critical for specific cellular structures. The microvilli of intestinal brush border cells in Myo6sv homozygotes are shorter than normal. While myosin 6 is not critical for the development of hair cell stereocilia, it is essential for their maintenance. At birth the stereocilia appear nearly normal with only occasional stereocil ..... | ||
| 008647 | B6.129P2(Cg)-Trpa1tm1Kykw Tyrc-2J/J | Cryopreserved - Ready for recovery |
| Exons encoding the pore domain of the transient receptor potential cation channel, subfamily A, member 1 gene were deleted in this targeted mutation strain. Animals show reduced sensitivity to pain. RT-PCR of dorsal root ganglia confirmed the absence of mRNA in homozygous mutant mice. Homozygotes are viable and fertile. | ||
| 000383 | B6.C-Tyrc H1b Hbbd/ByJ | Cryopreserved - Ready for recovery |
| 007484 | B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ | Cryopreserved - Ready for recovery |
| On an albino background the X-linked transgene Tg(Tyr)3412ARpw permits visual identification of XX versus XY as early as embryonic day 10.5. This strain is segregating for Tg(Tyr)3412ARpw and homozygous for Tyrc-2J so the individuals not carrying Tg(Tyr3412)ARpw are albino. Because Tg(Tyr)3412ARpw inserted into the X Chromosome, breeding a carrier male with a noncarrier (wild-type) female results in embryos in which all XX individuals develop eye pigment, due to the Tg(Tyr)3412ARpw inherited from their father, while all XY individuals have non-pigmented eyes, having inherited a wild-type X Chromosome from their mother.
This strain also carries Tg(SryEGFP)92Ei. This reporter transgene consists of a 5 prime regulatory segment of the Sry gene driving EGFP. This transgene is expressed in the pre-support cell lineage (pre-sertoli and pre-granulosa cells) of the fetal genital ridge (Albrecht and Eicher, 2001) and in discrete areas the adult male but not female br ..... | ||
| 000035 | B6.Cg-Tyrc-J/J | Cryopreserved - Ready for recovery |
| 000104 | B6.Cg-Tyrc-h/J | Cryopreserved - Ready for recovery |
| 000054 | B6.D2-Tyrc-p/J | Cryopreserved - Ready for recovery |
| The coat color of mice homozygous for the platinum mutation is nearly albino, cream colored, and these mice have pink eyes and a sheen to their coat. These homozygotes are lighter in color than chinchilla homozygotes despite having more tyrosinase activity in their cells. This is due to the altered subcellular localization of platinum tyrosinase. (Dickie M., 1966.) | ||
| 000339 | C3H/HeJ-Tyrc-9J/J | Cryopreserved - Ready for recovery |
| 001294 | C3H/HeJ-Tyrc-a/J | Cryopreserved - Ready for recovery |
| 001002 | C57BL/10SnJ-Tyrc-11J/J | Cryopreserved - Ready for recovery |
| 001006 | CBA/J-Tyrc-10J/J | Cryopreserved - Ready for recovery |
| 000619 | FS/EiJ | Cryopreserved - Ready for recovery |
| The FS/Ei strain was originally used as a linkage testing stock for gene mapping. It is homozygous for several visible recessive mutations including brown (Tyrp1b), pink-eyed dilution (Oca2p), chinchilla (Tyrc-ch), frizzy (fr), and the neurological mutation shaker 1 (Myo7ash1). It is also homozygous for a couple allelic variants that can be easily typed (Mod2b and Hbbd). Mice homozygous for the shaker 1 show circling, head-tossing, deafness, and hyperactivity characteristic of this type of mutant mice. Viability is normal, and breeding ability is high for a circling mutant. Homozygous mutant mice are most often deaf and swim well on the surface of water up to 4 weeks of age and more but lose the ability later. The degenerative changes of the labyrinth may occur a little later than in some of the other waltzing mutants. By light microscopy, the changes are seen to consist ..... For more information please see the full phenotype on the strain data sheet | ||
| 000494 | J.Cg-Oca2+ Tyr+ Lystbg/J | Cryopreserved - Ready for recovery |
| Mice homozygous for the beige spontaneous mutation (Lystbg) are characterized by a condition that closely resembles Chediak-Higashi disease in man and similar conditions in mink and cattle. Abnormal giant lysosomal granules occur in all tissues with granule-containing cells, including granulocytes, lymphocytes, cells of the liver, kidney, central nervous system, pancreas, and thyroid, and the ducts of most glands; in type II pneumocytes; in mast cells; and in retinal pigment epithelium. Granulocytes from beige homozygous mutant mice mice show defective chemotaxis and reduced bactericidal activity. Beige mice are more susceptible than controls to pneumonitis and to various viral, bacterial, and parasitic infections. Natural killer (NK) cells from beige mice exhibit decreased endogenous cytotoxic activity. Beige mice also have a defective cytotoxic T-cell and cytotoxic antibody response to allogeneic tumor cells. Syngeneic tumor cells grow better in beige mice than in l ..... For more information please see the full phenotype on the strain data sheet | ||
| 002281 | NFS.C58-Tyr+/J | Cryopreserved - Ready for recovery |
| 004304 | NOD.CBALs-Tyr+/LtJ | Cryopreserved - Ready for recovery |
| This Chr 7 congenic strain in which the tyrosinase allele Tyr+ of the CBA/JLsLt strain is fixed on the NOD/Lt background, therefore making the strain agouti in color. This strain should be a good donor for blastocysts in which to microinject targeted NOD ES cells, and may alleviate unwanted genome integration experienced with use of the C57BL/6 blastocysts. The congenic segment on Chromosome 7 slightly supresses spontaneous T1D development which is an asset when these females are used as blastocyst recipients. | ||
| 000271 | SH1/LeJ | Cryopreserved - Ready for recovery |
| Mice homozygous for the shaker 1 spontaneous mutation (Myo7ash1) show circling, head-tossing, deafness, and hyperactivity characteristic of this type of mutant mice. Viability is normal, and breeding ability is high for a circling mutant. Homozygous mutant mice are most often deaf and swim well on the surface of water up to 4 weeks of age and more but lose the ability later. The degenerative changes of the labyrinth may occur a little later than in some of the other waltzing mutants. By light microscopy, the changes are seen to consist of degeneration of the organ of Corti, the spiral ganglion, and the stria vascularis in the cochlea, and of the saccular macula and the vestibular ganglion in the vestibular labyrinth. | ||
| 001759 | STOCK A Tyrc Sha/J | Cryopreserved - Ready for recovery |
| 000306 | STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J | Cryopreserved - Ready for recovery |
| 000006 | STOCK Hk Tyrc/J | Cryopreserved - Ready for recovery |
| While mice carrying the Hk mutation often have a hooked curl at the end of a shortened tail, this mutation may more consistently result in a displaced anus that is positioned posterior to the normal site and is more slit-shaped than circular. In some instances the anus has been located in the beginning of the tail and a depression was found to extend partway down the ventral side of the tail (Holman, 1951). The Hk mutation is semidominant with homozygotes often showing a shorter, more affected tail than heterozygotes (P.W. Lane Personal Communication). | ||
| 000206 | STOCK a/a Tyrc-h/J | Cryopreserved - Ready for recovery |
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