Search Criteria: Research Area is "Mouse/Human Gene Homologs: Bruton agammaglobulinemia tyrosine kinase"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 001011 | CBA/CaHN-Btkxid/J | Level 2 |
| CBA/CaHN-Btkxid/J mice have a mutation in the Bruton's tyrosine kinase gene (Btk), and are a model of human X-linked immunodeficiency. They have a B-lymphocyte-specific defect that results in an inability to launch an antibody response to thymus-independent type II antigens, although they do produce normal amounts of antibody in response to some protein antigens. They have low serum IgM and IgG3 and a reduced number of B-cells. Moreover, the B-cells that are present have a reduced surface IgM to IgD ratio, which suggests a disorder in B-cell maturation. | ||
| 002536 | B6;129S-Btktm1Wk/J | Repository-Cryopreserved |
| Mice homozygous for the Btktm1Wk targeted mutation are viable and fertile. Homozygous mutant mice show defects in B-cell maturation and activation. This strain has the same phenotype as the spontaneous X-linked immune deficiency mutation (CBA/CaHN-Btkxid/J; Stock No. 001011). See Inbred Strain listing. | ||
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