Jackson Laboratory manuals - The Jackson Laboratory

Manuals

Manuals are available on the following topics:

Pathways to Discovery: Autoimmune Diseases
Working with ALS Mice
Autoimmune disease
Breeding strategies
Cancer
Cardiovascular
Genetic background
Infectious disease
Neurobiology
Research tools
Sensorineural research
Type 2 diabetes & obesity

Pathways to Discovery: Autoimmune Diseases

To assist researchers investigating molecular commonalities among different autoimmune diseseas, in silico data mining and pathway software were used to integrate the gene/pathway interactions between inflammatory bowel disease (IBD), rheumatoid arthritis, asthma, multiple sclerosis (MS), and psoriasis.

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	Working with ALS Mice This informative resource, prepared by scientists with Prize4Life and The Jackson Laboratory, discusses considerations for preclinical studies using SOD1 mice, colony management, QPCR protocol for determining copy number, and provides a sample neurological scoring system and template pedigree ledger. Request a copy of Working with ALS Mice back to top
	Autoimmune Disease Research This resource manual highlights the extensive resources available from The Jackson Laboratory to help biomedical researchers with their mouse-based autoimmune disease research. It includes over 70 JAX^® Mice models as well as JAX^® Services appropriate for autoimmune disease research. Request a copy of the autoimmune disease resource manual back to top
	Breeding Strategies for Maintaining Mice Colonies This manual describes breeding strategies and techniques for maintaining colonies of laboratory mice. These techniques have been developed and used by The Jackson Laboratory for over 75 years. They are safe, reliable, economical, efficient, and ensure that the mouse strains produced are genetically well defined. Request a copy of the breeding strategies resource manual back to top
	Cancer Research The purpose of the Cancer Resource Manual is to inform investigators of the extensive resources available for cancer research at The Jackson Laboratory. They include hundreds of cancer research mouse models, publicly accessible databases such as the Mouse Tumor Biology Database, courses and conferences on and related to cancer and stem cell research, and the results of research by Jackson Laboratory scientists. Request a copy of the cancer resource manual back to top
	Cardiovascular Research This manual highlights and compares more than 30 JAX^® Mice models suitable for cardiovascular research. It also describes other Jackson Laboratory resources, including courses, Web sites, and JAX^® Services, as well as briefly summarizing relevant research conducted by Jackson Laboratory Investigators. Request a copy of the cardiovascular resource manual back to top
	The Importance of Genetic Background This resource manual explains the importance of using genetically well-defined mice for biomedical research, describes The Jackson Laboratory's resources for helping researchers choose those mice, encourages researchers to clearly communicate the genetic make-up of their models by using proper nomenclature, and summarizes The Jackson Laboratory's programs to ensure that JAX^® Mice are genetically well-defined. Request a copy of the genetic background resource manual back to top
	Infectious Disease Research This manual briefly describes various infectious diseases, summarizes selected studies, and describes JAX^® Mice models useful for researching these diseases: HIV (AIDS), anthrax, botulism, ebola, plague, smallpox, and tularemia. Request a copy of the infectious disease resource manual back to top
	Neurobiology Research The Neurobiology Resource Manual summarizes the neuroscience research of Jackson Laboratory scientists, describes Jackson Laboratory courses and web sites related to neuroscience research, and showcases nearly 30 of over 600 JAX^® Mice models suitable for neurobiology research. Request a copy of the neurobiology resource manual back to top
	Research Tools The development of cutting-edge genetic tools such as Cre-lox, FLP-FRT, and fluorescent proteins has revolutionized the ability of research scientists to manipulate the mouse genome. These relatively new technologies, combined with more traditional tools, including Tet and lacZ expression systems, provide abundant possibilities for developing a new generation of genetically engineered mice to study normal gene function(s), and how alteration of these functions leads to disease. This manual is a guide to understanding the basic mechanisms of these technologies, how “research tool” mouse strains that implement these technologies can be used, and how to find these strains in the JAX^® Mice Database. Request a copy of the research tools manual back to top
	Sensorineural Research This Resource Manual briefly describes the sensorineural research conducted by Jackson Laboratory scientists, over 20 of the hundreds of suitable JAX^® Mice, JAX online resources, and Jackson Laboratory courses and conferences relevant to sensorineural research. Request a copy of the sensorineural research resource manual back to top
	Type 2 Diabetes & Obesity Research This manual describes and compares traditional and newly-developed JAX^® Mice models of type 2 diabetes and diet-induced obesity (diabesity), describes the Diet Induced Obesity, Compound Evaluation, and Model Characterization programs offered by JAX^® Services, summarizes the research of Jackson Laboratory scientists investigating diabetes and associated diseases, and lists the major diabetes-associated resources available to the biomedical research community. Request a copy of the type 2 diabetes & obesity resource manual back to top