The Jackson Laboratory

• Pathways to Discovery: Autoimmune Diseases
• Working with ALS Mice
• SMA Mice Reference Guide

• Breeding strategies 
• Genetic background 

Pathways to Discovery: Autoimmune Diseases

To assist researchers investigating molecular commonalities among different autoimmune diseseas, in silico data mining and pathway software were used to integrate the gene/pathway interactions between inflammatory bowel disease (IBD), rheumatoid arthritis, asthma, multiple sclerosis (MS), and psoriasis.

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Working with ALS Mice

This informative resource, prepared by scientists with Prize4Life and The Jackson Laboratory, discusses considerations for preclinical studies using SOD1 mice, colony management, QPCR protocol for determining copy number, and provides a sample neurological scoring system and template pedigree ledger.

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Reference Guide to Mouse Models of Spinal Muscular Atrophy

This reference guide summarizes the history of SMA mouse model development. It describes the original models developed in the laboratories of Drs. Michael Sendtner at the University of Worzburg and Arthur Burghes at Ohio State University, the latest models that allow temporal and tissue specific control of SMN expression, and models under development. It includes protocols for maintaining SMA models, criteria for choosing the right model(s), and techniques for maintaining the genetic and phenotypic integrity of future models.

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Breeding Strategies for Maintaining Mice Colonies 

This manual describes breeding strategies and techniques for maintaining colonies of laboratory mice. These techniques have been developed and used by The Jackson Laboratory for over 75 years. They are safe, reliable, economical, efficient, and ensure that the mouse strains produced are genetically well defined.

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The Importance of Genetic Background 

This resource manual explains the importance of using genetically well-defined mice for biomedical research, describes The Jackson Laboratory's resources for helping researchers choose those mice, encourages researchers to clearly communicate the genetic make-up of their models by using proper nomenclature, and summarizes The Jackson Laboratory's programs to ensure that JAX^® Mice are genetically well-defined.

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