Manuals

For comprehensive lists of JAX® Mice strains specific to diverse areas of mouse genetics and disease research, please visit our research area pages.

Manuals are available on the following topics:

 

Humanized NSG for infections disease Guide

Humanized NSG Mice for Infectious Disease Research

Humanized NSG mice are used by researchers and drug discovery scientists as powerful tools to study hematopoiesis, inflammatory disease and viral host-pathogen interactions. These mouse models are accelerating the development of novel therapies in HIV infection and oncology. Inside this guide you will find:

  • Key steps to develop humanized mice
  • How to select between hu-CD34 NSG, hu-BLT NSG or hu-PBMC NSG models
  • Applications in HIV, Dengue virus and Epstein-Barr infectious disease research

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HD

A Field Guide to Working with Mouse Models of Huntington's Disease

Working jointly with CHDI and PsychoGenics, Inc., we now have this valuable resource available for you. Inside the field guide you'll find:

  • List of mouse models of Huntington’s disease
  • Best practices for managing Huntington’s disease mouse colonies
  • Preclinical research study design considerations

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ALS

Working with Amyotrophic Lateral Sclerosis (ALS) Mouse Models

Guidelines for preclinical testing and colony management

This informative resource, prepared by scientists with Prize4Life and The Jackson Laboratory, discusses considerations for preclinical studies using SOD1 mice, colony management, QPCR protocol for determining copy number, and provides a sample neurological scoring system and template pedigree ledger.

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SMA

Reference Guide to Mouse Models of Spinal Muscular Atrophy

This reference guide summarizes the history of SMA mouse model development. It describes the original models developed in the laboratories of Drs. Michael Sendtner at the University of Worzburg and Arthur Burghes at Ohio State University, the latest models that allow temporal and tissue specific control of SMN expression, and models under development. It includes protocols for maintaining SMA models, criteria for choosing the right model(s), and techniques for maintaining the genetic and phenotypic integrity of future models.

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