In this issue:
- Colony management solutions
- New JAX® Mice Price List
- The JAX® Mice difference
- Join us at the American Diabetes Association Meeting
- JAX® Mice strains under development
- Recent publications co-authored by Jackson Laboratory professors
Colony management solutions
Make better use of limited resources and and simplify all aspects of managing your mouse colonies—all with our breeding and cryopreservation services. You can depend on our expertise maintaining laboratory mice. Our experience maintaining the world's largest mouse model collection enables us to develop cost-effective, time-efficient breeding solutions to fit your needs. In addition, we have successfully cryopreserved and recovered more than 5,000 mouse strains. Contact us today to simplify and accelerate your research.
New JAX® Mice Price List
Our new 2008-2009 JAX® Mice Price List includes over 500 new strains. To request a copy of the new Price List (available June 1), please visit our Web site. For a list of new strains by research area, visit our newly released strains webpage.
The JAX® Mice Difference
Not only are JAX Mice the most published and well characterized, they are healthiest, most genetically stable models available, and they are supported by our exper technical scientists. Learn how we ensure the integrity of JAX® Mice for your research with our animal health and genetic testing and monitoring programs or contact our technical support team today.
Join us at the American Diabetes Association Meeting
Stop by booth 226 at ADA in San Francisco, CA, from June 6-9, 2008 to meet our research scientists, product managers, and technical support, customer service and regional representatives. View a list of future meetings we will be attending.
New JAX® Mice strains under development
You can find more information about these and other JAX® Mice strains by searching the JAX® Mice Database. To submit your unique research strain(s) to our international repository for mouse models, see our Strain Submission Form.
- 129S1-Sv-Sufutm1Aeb/J (007859) Mice homozygous for the suppressor of fused homolog (Drosophila) (Sufu) gene are viable and fertile. This mutant mouse strain represents a model that may be used to study neuronal differentiation.
- B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J (005895) These Clone-1 TCR (also called Clone 1 Thy1.1 TCR or Cl.1 TCR) transgenic mice were designed to optimize conditions for tumor eradication by low avidity tumor-specific T cells and may also be used to study T cell avidity, tolerance, positive/negative selection, and activation.
- B6.129-Fut1tm1Sdo/J (006939) Fucosyltransferase 1 (Fut1) -deficient mice do not have epididymal alpha(1,2)fucosylated glycans or the fucosylated glycolipid, fucosyl GA1, in pancreatic acinar glands. Homozygotes exhibit delayed maturation of nerve fibers in the glomerular layer of the olfactory bulb. This mutant mouse strain may be used to study glycosidic molecular interactions and function, and olfactory nerve pathway development.
- B6.129-Mgl1tm1Hed/J (006944) Macrophage galactose N-acetyl-galactosamine specific lectin 1 (Mgl1) -deficient mice exhibit slightly increased red blood cell counts, mean corpuscular hemoglobin, hematocrit and mean corpuscular volume when compared to wildtype controls. Homozygotes have diminished antigen-induced granulation tissue formation. This mutant mouse strain may be used to study glycosidic molecular interactions and function, antigen-specific and antigen-independent cellular immune response and hematopoiesis.
- B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J (008135) Hemizygous transgenic mice are viable and fertile and develop a Parkinson-like phenotype upon aging. Hind limb paralysis due to loss of motor neurons and a resting tremor are initially seen at about 6 months of age. No Lewy body-like pathology is noted. Cell death in the spinal cord (extensive) and brain are observed.
- B6;129P2-Pvalbtm1(cre)Arbr/J (008069) This strain expresses Cre recombinase from the endogenous Pvalb, parvalbumin, locus. When crossed with a strain containing a floxed target sequence of interest, Cre-mediated recombination results in deletion of the target in interneurons in the brain and sensory neurons in the dorsal root ganglia.
- B6;SJL-Tg(Tagln-tTA)1Mrab Tg(tetO-Mcpt1)1Mrab/J (008082) These SM22a-tTA/TRE-RVCH-HA bi-transgenic mice allow targeted overexpression or Tet-Off conditional expression of vascular chymase in smooth muscle cells, and may be used to study elevated chymase activity in systemic hypertension and cardiovascular disease.
- BXD70/RwwJ (007115) The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664) females and DBA/2J (000671) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug , stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).
- (C57BL/6-Tg(TRAMP)8247Ng/J X FVB/NJ)F1/J (008215) These transgenic mice express the simian virus 40 (SV40) large tumor T antigen (Tag) under the control of the rat probasin promoter. Mice carrying the TRAMP (Transgenic Adenocarcinoma of Mouse Prostate) transgene develop progressive forms of prostate cancer with distant site metastasis, primarily to the lymph nodes and lungs.
- NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ (008173) Congenic NOD mice hemizygous for enhanced green florescent protein, EGFP, under the control of the Mouse Insulin I promoter, InsI, (MIP-GFP) express green florescence in tissues where insulin I is normally detected, specifically in pancreatic beta-cells. Transgenic female mice develop insulitis and diabetes at a similar or higher rate as wildtype controls. Transgenic mice may be used to study diabetes and pancreatic beta islet cell biology.
- NOD.FVB-Tg(Igh-6-Cd80)1Gjf/JbsJ (007769) This congenic NOD strain contains a transgene encoding murine Cd80 controlled by IgM enhancer and promoter elements and is commonly referred to as NOD.B7-1B Tg. The donating investigator reports that this diabetes resistant strain expresses high levels of the transgene on B cells, but not on T-cells. Circulating, splenic, and bone marrow B cells are significantly reduced. This strain may be used to study autoreactive T cell activation, B cell depletion and the role of B7 costimulatory molecules in autoimmunity, specifically Type 1 Diabetes.
- STOCK Gt(ROSA)26Sortm1(Notch1)Dam/J (008159) Expression of the Notch1 intracellular domain fragment and GFP is blocked by a loxP-flanked STOP fragment placed between the coding sequence the the GT(ROSA)26Sor promoter. When used in conjunction with a Cre recombinase-expressing strain, these RosaN1-IC mutant mice may be useful in generating conditional mutations for studying the effects of Notch pathway activation.
- STOCK Tg(Ins2-cre/Esr1)1Dam/J (008122) When these RIP-CreER mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in pancreatic beta cells. This mutant mouse strain may be used to study pancreatic development, diabetes and obesity.
- STOCK Tg(Ins2-rtTA)2Efr/J (008250) Ins-rtTA or RIP7-rtTA transgenic mice express the reverse tetracycline-controlled transactivator (rtTA) protein under the control of the rat insulin 2 promoter. When mated to a second transgenic strain carrying a gene under the regulatory control of a tetracycline-responsive promoter element (TRE or tetO), expression of the gene in pancreatic beta cells is induced with administration of the tetracycline analog, doxycycline (dox). This strain provides a Tet-On tool that allows the inducible expression of genes in pancreatic beta cells.
- STOCK Tg(Neurog3-cre/Esr1)1Dam/J (008119) When these Ngn3/CreER mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Neurog3 expressing cells such as pancreatic islet cells and undifferentiated spermatogonia. This mutant mouse strain may be used to study pancreatic development and lineage mapping of Neurog3 expressing cells.
- STOCK Tg(tetO-DTA)1Gfi/J (008168) These tet-diphtheria toxin A mice may be used to generate bi-transgenic mice mutants for reversible, inducible deletion of specific groups of cells.
Recent publications co-authored by Jackson Laboratory professors
Lozier J, McCright B, Gridley T. Notch signaling regulates bile duct morphogenesis in mice. PLoS ONE 2008 Mar; 3(3):e1851. PubMed:[18365007]
Mackiewicz M, Paigen B, Naidoo N, Pack AI. Analysis of the QTL for sleep homeostasis in mice: Homer1a is a likely candidate. Physiol Genomics 2008; 33:91-99. PubMed:[18171722]
Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, DePinho RA, Wong K-K. Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. Carcinogenesis 2008; 29(4):747-53. PubMed:[18283039]
Renaud J, Kerjan G, Sumita I, Zagar Y, Georget V, Kim D, Fouquet C, Suda K, Sanbo M, Suto F, Ackerman SL, Mitchell KJ, Fujisawa H, Chédotal A. Plexin-A2 and its ligand, Sema6A, control nucleus- centrosome coupling in migrating granule cells. Nat Neurosci 2008 Apr; 11(4):440-9. PubMed:[18327254]
Stylianou IM, Affourtit JP, Shockley KR, Wilpan RY, Abdi FA, Bhardwaj S, Rollins J, Churchill GA, Paigen B. Applying gene expression, proteomics and single-nucleotide polymorphism analysis for complex trait gene identification. Genetics 2008 Mar; 178(3): 1795-805. PubMed:[18245842]
Wong SY, Crowley D, Bronson RT, Hynes RO. Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer. Clin Exp Metastasis 2008; 25:109-118. PubMed:[18058030]
Thank you for your interest in JAX® Mice and Services.
Jennifer Guilmet
Regional Representative
The Jackson LaboratoryEmail: jennifer.guilmet@jax.org
Tel: 617-780-2566
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