New JAX Microinjection Services

New JAX^® Microinjection Services
We offer both DNA microinjection and ES cell microinjection services to producing genetically modified mice.

Research tools for neurobiological research
Looking for Cre-, fluorescent protein-, FLP-FRT-, TET-, or lacZ-expressing mouse strains for your neurobiology research? Check out the Research Tools section of the JAX^® Mice Database. Learn more about this new resource at our website. You can also request our new Reseach Tools Resource Manual.

Colon Cancer in Murine Models and Humans
This Jackson Laboratory meeting will discuss the development and validation of accurate preclinical rodent models and their use in translational cancer research. To learn more about this October 2009 meeting, visit our website.

Expanded Sacramento operations
In early 2009, a new, state-of-the-art JAX® Mice & Services facility in Sacramento will begin producing greater numbers and a wider selection of popular JAX^{^®} Mice strains. We will also offer more extensive breeding, in vivo, cancer and stem cell services, and greater customization of those services.

B6(Cg)-Tyr^c-2J/J - An ideal mouse for creating knockouts
B6(Cg)-Tyr^c-2J/J (000058), or B6-albino mice, are ideal for producing novel strains with targeted mutations. To learn why, visit the strain data sheet.

New JAX^{^®} Mice strains under development
You can find more information about these and other JAX^{^®} Mice strains by searching the JAX^{^®} Mice Database. If you are interested in submitting your unique research strain(s) to our international repository for mouse models, see our Strain Donation Form.

129S/Sv-Kras^tm4Tyj/J (008180) This strain carries a point mutation (G12D) in the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (Kras) gene. Homozygotes die in utero. Cre-mediated recombination can excise the stop codon and permit the oncogenic protein to be expressed. This strain may be used to study cancer and development.
B10(Cg)-Cacna1a^Tg-5J/LetJ (008623) Mice heterozygous for this semi-dominant spontaneous mutation of the calcium channel, voltage-dependent, P/Q type, alpha 1A subunit gene have a shaky gait. They may be used to study epilepsy and voltage-dependent calcium channels.
B6.129P2-Gt(ROSA)26Sor^tm1(tTA)Roos/J (008600) These mutant mice may be used to generate compound mutant mice that express a tetracycline-responsive promoter element-driven gene of interest, which can be directed to the cell types defined by the chosen Cre recombinase expression, and turned off by the addition of tetracycline.
B6.129S-Cstf2t^tm1Ccma/J (008370) Male mice that are homozygous for this targeted mutation of cleavage stimulation factor, 3' pre-RNA subunit 2, tau (Cstf2t) are infertile due to defective spermatogenesis. This mutant mouse strain may be used to study polyadenylation and translational regulation of protein synthesis during gametogenesis.
B6.C-Cacng2^stg-3J/LetJ (008624) Homozygotes for this spontaneous mutation of the calcium channel, voltage-dependent, gamma subunit 2 gene have an ataxic gait. Stargazer 3J mice may be used to study epilepsy and voltage-dependent calcium channels.
B6.C3Bir-Cacna1a^tg-4J/LetJ (008622) Homozygotes for this spontaneous mutation of the calcium channel, voltage-dependent, P/Q type, alpha 1A subunit gene have an ataxic gait, paroxysomal dyskinesia, and absence seizures. Tottering 4J mice may be used to study epilepsy and voltage-dependent calcium channels.
B6.Cg-Dmc1^tm1Jcs/JcsJ (008608) These mice have a targeted knockout mutation of the DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) gene (Dmc1). They may be used to study gametogenesis and meiosis, chromosome asynapsis, DNA repair mechanisms, homologous recombination, and the pachytene checkpoint.
B6.129S4-Gt(ROSA)26Sor^{tm3(phiC31o)Sor}/J (007743) These mutant mice express the mouse codon-optimized site-specific recombinase FC31o from the endogenous Gt(ROSA)26Sor locus. FC31o mediates irreversible DNA recombination at specific nonidentical pairs of sequence sites, attB and attP. This strain is an effective tool to generate tissue-specific targeted mutants.
B6.FVB-Tg(TACSTD1)02Leij/J (008426) These transgenic mice express the human tumor-associated calcium signal transducer 1 gene (TACSTD1). The transgene expression pattern is similar to the observed human pattern in both normal and tumor tissue. This strain may be used to study immunological therapies for cancer.
B6;129P-Tg(Neurog1-cre/ESR1)1Good/J (008529) When these Ngn1-CreER^T2 transgenic mice are bred with mice containing a loxP-flanked sequence of interest, they produce offspring in which tamoxifen-inducible, Cre-mediated recombination deletes the flanked sequences in Neurog1 expressing cells. This strain may be used to study neuron development and lineage mapping of Neurog1 expressing cells.
B6;C3-Tg(CAG-DsRed,-EGFP)5Gae/J (008605) This is a double-fluorescent, Cre-reporter strain with widespread expression of red fluorescence prior to Cre recombinase exposure, and green fluorescence following cre-mediated recombination in a pattern determined by cre expression. These mice can be used to analyze complex cellular relationships.
BXD49/RwwJ (007098)
BXD56/RwwJ (007104)
BXD64/RwwJ (007109)
BXD74/RwwJ (007118)
BXD79/RwwJ (007123)
The BXD#/Rww recombinant inbred strains may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).
C3H;101-Dync1h1^Swl/PopJ (008393) These mice harbor the radiation-induced Sprawling mutation of the cytoplasmic dynein heavy chain 1 gene (Dync1h1^Swl). They may be used to study microtubule motor protein function in sensory neuron degeneration, specifically in proprioceptive sensory neurons.
C57BL/6-Tg(HBB-cre)12Kpe/J (008314) These transgenic mice express Cre recombinase under the control of the human beta hemoglobin (HBB) promoter and intron 2-enhancer fragment, and the human beta hemoglobin locus control region (LCR). They may be used to generate tissue-specific targeted mutants to study erythropoiesis and hematopoiesis.
C57BL/6J-Tg(Nkx2-1-cre)2Sand/J (008661) These Nkx2.1Cre (or BAC-Nkx2.1-Cre) transgenic mice express cre under the control of the Nkx2.1 promoter/enhancer regions. They may be used to generate conditional mutations to study brain progenitor cells.
C57BLKS/J-Cacna2d2^du-2J/LetJ (008625) Homozygotes for the spontaneous mutation of the calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene exhibit ataxia, paroxysomal dyskinesia, and absence seizures. Ducky 2J mice may be used to study epilepsy and voltage-dependent calcium channels.
NOD.129P2(B6)-Cstl^tm1Cptr/RclJ (008352) This congenic NOD strain contains a neomycin cassette disruption in exon 3 of cathepsin L (Cstl^tm1Cptr) and homozygous mice are reported to be cathepsin L (Cstl) deficient. They are insulitis free and exhibit diabetes resistance. They may be used to identify the molecular pathways of major lysosomal cysteine proteases (specifically cathepsin L) in immune modulation.
NOD.129P2(B6)-Ctsb^tm1Jde/RclJ (008051) This congenic NOD strain contains a neomycin cassette disrupting exon 4 of cathepsin B (Ctsb^tm1Jde). Homozygotes are reportedly cathepsin B (Ctsb) deficient. They exhibit modestly delayed diabetes onset. They may be used to identify the molecular pathways of major lysosomal cysteine proteases (specifically cathepsin B) in immune modulation.
NOD.FVB-Tg(ITGAM-DTR/EGFP)34Lan/JdkJ (008547) Congenic NOD mice hemizygous for a simian diphtheria toxin receptor fused with green fluorescent protein under the control of human integrin alpha M, ITGAM, promoter (CD11b). They are a diphtheria toxin-inducible system that transiently depletes macrophages. They may be used to study type 1 diabetes.
STOCK Cacnb4^lh-2J/LetJ (008626) Homozygotes for this spontaneous mutation of the calcium channel, voltage-dependent, beta 4 subunit gene exhibit a lethargic behavior with gait instability and the occasional seizure. They may be used to study epilepsy and voltage-dependent calcium channels.
STOCK Foxa2^{tm1.1(rtTa)Moon}/J (008335) These Foxa2ITA/ITA transgenic mice express the reverse tetracycline-controlled transactivator (rtTA) protein from the forkhead box A2 (Foxa2) locus. They allow the inducible expression of genes in cells expressing FOXA2 for cardiac and neural development research.

Recent articles by Jackson Laboratory scientists

Anderson MG, Hawes NL, Trantow CM, Chang B, John SWM. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res 2008; 21:565-78.

Bailey JS, Grabowski-Boase L, Steffy BM, Wiltshire T, Churchill GA, Tarantino LM. Identification of quantitative trait loci for locomoter activation and anxiety using closely related inbred strains. Genes Brain Behav 2008; 7:761-9

Blake JA, Thomas M, Thompson JA, White R, Ziman M. Perplexing pax: from puzzle to paradigm. Dev Dyn 2008; 237:2791-2803.

Chen J, Lu Y, Lee C-H, Li R, Leiter EH, Mathews CE. Commonalities of genetic resistance to spontaneous autoimmune and free radical-mediated diabetes. Free Radic Biol Med 2008; 45:1263-70.

Croker BA, Lawson BR, Berger M, Eidenschenk C, Blasius AL, Moresco EMY, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci USA 2008; 105(39):15028-33.

Ghim S, Jenson AB, Bubier JA, Silva KA, Smith RS, Sundberg JP. Cataracts in transgenic mice caused by a human papillomavirus type 18 E7 oncogene driven by KRT1-14. Exp Molec Pathol 2008; 85:77-82.

Govoni KE, Donahue LR, Marden C, Mohan S. Complex genetic regulation of bone mineral density and insulin-like growth factor-I in C57BL/6J-Chr #A/J/NaJ chromosome substitution strains. Physiol Genomics 2008; 35:159-164.

Guan Y, Myers CL, Lu R, Lemischka IR, Bult CJ, Troyanskaya OG.. A Genomewide Functional Network for the Laboratory Mouse. PLoS Comput Biol 2008; 4(9): e1000165.

Pang J-J, Boye SL, Kumar A, Dinculescu A, Deng W, Li J, Li Q, Rani A, Foster TC, Chang B, Hawes NL, Boatright JH, Hauswirth WW. AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation. Inv Ophth Vis Sci 2008; 49:4278-83.

Peng Y-W, Zallocchi M, Meehan DT, Delimont D, Chang B, Hawes N, Wang W, Cosgrove D. Progressive morphological and functional defects in retinas from alpha1 integrin-null mice. Inv Ophth Vis Sci 2008; 49(10):4647-54

Strong R, Miller RA, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E, Nadon NL, Warner HR, Harrison DE. Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 2008; 7:641-50.

Stylianou IM, Langley SR, Walsh K, Chen Y, Revenu C, Paigen B. Differences in DBA/1J and DBA/2J reveal lipid QTL genes. J Lipid Res 2008; 49:2402-13.

Svenson KL, Ahituv N, Durgin RS, Savage H, Magnani PA, Foreman O, Paigen B, Peters LL. A new mouse mutant for the LDL receptor identified using ENU mutagenesis. J Lipid Res 2008; 49:2452-62.

Thank you for your interest in JAX^{^®} Mice and Services.

Jennifer Guilmet
Regional Representative
The Jackson Laboratory

Email: jennifer.guilmet@jax.org
Tel: 1-617-780-2566

The latest version of the popular JAX^® Mice Coat Color poster includes a variety of strains with colors ranging from albino to black.

Based on a customer request, the JAX pups poster has been newly revised to include pups from birth through day 14.

Our Volume Pricing Program provides additional cost savings of 2% off the list price of our two most widely used research strains C57BL/6J (000664) or BALB/cJ (000651).


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