News items and announcements by date - page 3

Stay in touch:  RSS Email twitter Facebook LinkedIn

September 3, 2014 MR Imaging for Monitoring Therapeutic Response in Live Mice
A new study in NeuroReport (Kim et al. 2014) describes a new non-invasive imaging technology for detection of amyloid plaques and monitoring of responses to drug treatments in mouse models of Alzheimer’s disease.
August 20, 2014 Desktop Wallpaper Calendars for September/October 2014
Free downloadable image for your desktop
August 19, 2014 Transgenic Parasites to Dissect Host-Pathogen Interactions During Toxoplasmosis
A new report in Infection and Immunity (Christian et al.  2014) describes a powerful new T. gondii cre-lox based fluorescent reporter system for tracking host-pathogen cell interactions which can provide new insights into how host cells respond in vivo to toxoplasmosis infection.
August 19, 2014 Transparent Mice for Connectome Phenotyping
A highly innovative new technique has been published in Cell (Yang et al. 2014) that renders whole organs, and even an entire mouse, optically transparent. This amazing new development allows creation of enhanced three dimensional imaging of fluorescently labeled cells within multiple organs.  Yang et al. demonstrated imaging from cells expressing fluorescent transgenes as well as labeling by viral transduction, small molecules, mRNA probes, and antibodies. Using this approach, researchers will be able to build a “connectome” to understand the structural relationships between cell populations in both normal and pathological conditions.
August 4, 2014 Inhibition of Bromodomain Proteins for Human Diffuse Large B-cell Lymphoma
A recent article in Clinical Cancer Research revealed a broad anti-tumor effect of the small molecule JQ1, an inhibitor of BET family of bromodomain proteins (including Myc), on human DLBCL cell lines or DLBCL tumor-engrafted mice, providing novel potential therapeutic strategies for therapy-resistant or recurrent human DLBCL.
July 23, 2014 Enhancer Hijacking in Medulloblastoma
New research published in Nature (Northcott et al. 2014) describes previously unreported mechanisms of activation of oncogenes leading to medulloblastoma. Using a combination of genomic and RNA sequencing data, the authors identified chromosomal structural variants (SV) that led to changes in proximity of oncogenes, GFI1 and GFI1B,  to enhancer elements that ultimately up-regulated gene expression. Transduction of mouse neuronal stem cells with GFI1 or GFI1B in combination with Myc stimulated development of tumors in orthotopically transplanted NSG host mice, establishing a new mouse platform for medulloblastomas. The new mechanisms described in this research may help to provide new insight into the development of other heterogeneous cancers and provide new targets for molecular therapy.
July 9, 2014 Induction of Autoimmunity in Humanized NSG Mice
A new publication in the Journal of Immunology (Vudattu, N. et al. 2014) provides evidence that treatment of “humanized” NSG mice with ipilimumab (CTLA-4 Ig) can disrupt immune tolerance and initiate features of autoimmune disease, making this the first small animal model of human specific autoimmunity. This research establishes humanized NSG mice as a new therapeutic platform to study pathogenesis of human autoimmunity and develop new therapeutic interventions with greater potential to translate to human patients suffering from a wide range of autoimmune diseases (ex. Type 1 diabetes, Lupus, Multiple Sclerosis, etc.).
July 8, 2014 One-Step Generation of Genetically Engineered Mice by CRISPR/Cas Systems
Two exciting articles in Cell revealed how the revolutionary CRISPR/Cas system can be used to generate multiple gene mutations, reporter alleles and conditional alleles in mice in one step. The power of this system will undoubtedly transform genetic and biological research and facilitate the development of novel molecular therapeutics for complex human diseases.
June 25, 2014 Desktop Wallpaper Calendars for July/August 2014
Free downloadable image for your desktop
June 24, 2014 Autoimmunity Triggered by Antigen Mimicry
New research published in PLoS One (Massilamany et al. 2014) used SJL/J mice (000686), a model of EAE and MS, to provide compelling evidence that infectious organisms may be involved in the initiation and potentiation of autoimmune disease.  Peptides from the infectious agents mimic the same peptides identified from myelin that stimulate auto-reactive T cells.  The authors showed that infections could both prime the auto-reactive cells to initiate disease and stimulate the activity of preexisting autoimmune cells.
June 24, 2014 Osteopontin Deletion Prevents the Development of Obesity and Hepatic Steatosis
An exciting new report in PLoS One (Lancha et al. 2014) describes how Osteopontin deficiency is protective against diet-induced obesity and liver steatosis, thereby identifying a novel therapeutic target for obesity.
June 10, 2014 Insulin Degrading Enzyme Inhibitor Modulates Glucose Tolerance and Uncovers Expanded Roles
An exciting new report in Nature (Maianti et al. 2014) describes the discovery of a new insulin-degrading enzyme (IDE) inhibitor that improves glucose tolerance in a model of pre-diabetes and identifies previously unknown roles for IDE in glucose homeostasis beyond insulin regulation.
June 10, 2014 Longevity Biomarkers Revealed from Inbred Mouse Strains
A recent article in Aging Cell demonstrates a new protocol to identify pro-longevity, anti-longevity or role switching biomarkers utilizing the aging study data published in the Mouse Phenome Database. Their protocol may provide insights beyond the scheme of biomarkers for long or short lifespan.
May 27, 2014 Hunting for the Cellular Targets in Huntington’s
A new publication in Nature Medicine (Wang et al. 2014) reports on the expression of mutant huntingtin protein (mHTT) in specific regions of the brain and defines the cellular targets for optimal therapeutic intervention. The authors used Cre-Lox technology to diminish mutant protein expression in cortical or striatal neurons or in both regions of the brain. Mice were analyzed for improvement in motor function, psychiatric-like behaviors, and neurodegeneration. Results indicate that both regions of the brain may need to be targeted to obtain optimal therapeutic intervention.
May 26, 2014 Searching for the Secret Ingredients of the Fountain of Youth
Two recent exciting articles in Science and Nature Medicine demonstrated that exposure to young blood in aged mice is capable of rejuvenating heart and muscle tissue and improving synaptic plasticity along with cognitive functions. These studies revealed two critical players in these processes which may represent potential therapeutic targets for age-related disorders.
May 14, 2014 Effects of Cage Density on Inbred Mice
A recent article by Morgan et al. investigated the effect of housing density in five different inbred strains. The researchers from The Jackson Laboratory found that increased housing density for mice has no adverse effects and may even result in less stress— indicating that mice can be housed at higher densities than currently recommended by the Guide for the Care and Use of Laboratory Animals.
May 13, 2014 Transcranial Amelioration of Inflammation and Cell Death after Brain Injury
Investigators at the NIH (Roth et al.) describe a novel traumatic brain injury mouse model and delivery route for small molecule therapeutics that uncovers a role for inflammation in meningeal cell death.
April 29, 2014 Precise Genetic Mapping in Diversity Outbred Mice Identifies a Novel Pain Gene
Identifying drugable target genes that modulate human disease is a vital step in the drug discovery process.  The Diversity Outbred mice are a powerful tool to more rapidly identify new target genes.
April 15, 2014 Using “Don’t Eat Me” as an “Eat Me” Signal to Treat Cancer
An exciting report provides preclinical data that a monoclonal antibody can block the binding of CD47 on cancer cells to SIPRα on macrophages, converting a  “don’t eat me”  signal to “eat me”. This innate immunomodulatory approach used NSG mice engrafted with a variety of different human tumor types to demonstrate elimination of tumors, increased survival of the host, and phagocytosis of metastasizing tumor cells.   
April 15, 2014 Improving Translational Research: Make Your Mouse Studies Work
An inconvenient truth about translational research is that the success rate in developing patient therapeutics is unacceptably low. A recent article provides guidelines and recommendations to make animal models to work better and calls for more investment and due diligence to characterize animal models to boost the ability of preclinical work to predict drug effects in humans.
April 15, 2014 Desktop Wallpaper Calendars for April/May 2014
Free downloadable image for your desktop
April 1, 2014 Nanomedicine-Based Statin Delivery Inhibits Atherosclerotic Plaque Development
Atherosclerosis is a progressive inflammatory disease affecting arterial blood vessels.   Recently published in Nature Communications, Duivenvoorden et al. describe a novel nanomedicine that significantly reduces plaque area and inflammation.
April 1, 2014 Humanized FcRn Mice: New Models for Evaluating Pharmacokinetics of Human Therapeutic Antibodies
New models of humanized mice that are designed for evaluating therapeutic mAbs are presented and reviewed in a recent publication in Methods (G. Proetzel and D.C. Roopenian 2014). This article provides compiling evidence supporting the invaluable role of humanized FcRn models as strong and viable alternatives to primate PK studies of humanized mAbs and Fc-based compounds.
March 18, 2014 Breast Cancer Metastasis—not just an individual, but a group effort
A new publication in Cell (Cheung et al. 2013) uncovers a subpopulation of cells in luminal breast tumors lead a multicellular “collective invasion” of surrounding tissue.
March 18, 2014 Spontaneous Hair Cell Regeneration in Neonatal Mouse Cochlea
In a recent report published in Development (Cox et al.) designed two genetic mouse models for hair cell ablation, and found spontaneous regeneration in the cochlea of neonatal mice.
Older articles...