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February 17, 2014 Protection from HIV using VIP in BLT NSG!
An intriguing new publication in Nature Medicine (Balazs et al. 2014) provides preclinical evidence supporting the use of Vectored Immunoprophylaxis (VIP) to prevent transmission of HIV.  BLT NSG mice with human mucosal immunity were infected with HIV intravaginally, establishing a model of human heterosexual transmission. Humanized mice pretreated with VIP produced blocking antibodies that prevented HIV infection despite multiple viral exposures through the vaginal mucosa.
February 17, 2014 Antibody Directed Against TNFRSF21 is Neuroprotective in the SOD1*G93A Model of ALS
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord.  In a recent study published in Cell Death and Disease (Huang et al. 2013), inhibition of TNFRSF21 leads to motor neuron survival and functional improvement in a transgenic mouse model of ALS.
February 13, 2014 Register Today for Our Complimentary, Information-Rich Webinars

Join us for our latest webinars as we share valuable information on the innovative approaches to preclinical research and discovery using NSG mice, practical considerations for the care and housing of immune deficient mic, maximizing the productivity of your mouse breeding colonies, and minimizing naturally occurring genetic drift. We are also proud to present two new webinars focusing on Huntington's Disease and Advances in Genetic Research.

February 4, 2014 Humanized Mouse Model of Muscular Dystrophy
A new publication in Human Molecular Genetics (Zhang et al. 2014) describes a new mouse model of human skeletal muscle xenoengraftment in NRG immunodeficient mice.  These researchers demonstrated long term functional engraftment of skeletal muscle from normal and affected patients with Facioscapulohumeral Muscular Dystrophy (FSHD).
February 3, 2014 Deficiency of the ER Stress Protein Herpud1 Suppresses Atherosclerosis in Apoe Knockout Mice
ER stress has been implicated in the inflammatory response and progression of atherosclerotic lesions. A recent publication in PLoS One (Shinozaki, S. et al. 2013) demonstrates that a deficiency in the ER Stress protein Herpud1 suppresses atherosclerosis without altering plasma lipid levels.
January 22, 2014 New strains for research involving knockout mouse project (KOMP) mutations
FLP and Cre transgenic strains are now available on the same genetic background as KOMP alleles
January 22, 2014 Mesenchymal Stem Cells enhance islet transplantation in diabetic humanized mice
A recent publication in Molecular Therapy (Wu, H. et al. 2013) reports that human Mesenchymal Stem Cells can help improve primary function of transplanted human insulin producing β cells in a humanized NSG mouse made hyperglycemic by treatment with STZ. The Mesenchymal Stem Cells were also shown to suppress immune reaction by human peripheral blood cells towards the engrafted β cells. These results bring patients another step closer to successful islet replacement therapy.
January 22, 2014 Don't Miss the February JAX WebinarsTM. Reguster Today for Our Complimentary, Information-Rich Webinars 
The February JAX WebinarTM series shares valuable information from the expert research staff at The Jackson Laboratory on selecting immune deficient mouse models, innovative approaches to preclinical research and discovery using NSG mice, and practical considerations for the care and housing of immune deficient mice.
January 3, 2014 Genetics of Cocaine Addiction Uncovered Using C57BL/6 Mice
A single mutation controls differences in cocaine response between B6 substrains
January 3, 2014 Uncovering a Role for MicroRNA in Lupus-like Autoimmune Disease
A new report in in PNAS (Thai et al. 2013) demonstrates that deletion of miR-155 in a mouse model of systemic lupus erythamosus (SLE) alleviates multiple disease phenotypes.
December 20, 2013 An Expanded Color Palette for Fluorescent Imaging in the Mouse
New Brainbow strains enable clearer imaging of neurons and other tissues
December 18, 2013 Type 1 Diabetes Research Update: Tolerance Independent of Programmed Death
A new publication in International Immunology (Mukherjee et al. 2013) describes an important new approach to treat autoimmune Type 1 diabetes. This is a step forward in the development of a unique treatment to shut down immune destruction in T1D and potentially other autoimmune diseases.
December 18, 2013 Don't Miss the January Webinar Series
The January series features three webinars focused on selection and care of both type 1 and type 2 diabetes mouse models as well as a new webinar on the use of immune deficient mice for diabetes research.
December 17, 2013 Desktop Wallpaper Calendars for January 2014
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December 5, 2013 What can “Wicked High Cholesterol” mice teach us about heart disease?
Mutagenesis screens identify new genes important for understanding atherosclerosis.
November 26, 2013 Photoreceptor Cells Stress and Inflame the Retina in Diabetic Retinopathy
Diabetic retinopathy is a secondary complication of diabetes that diminishes quality of life and impacts the majority of long-term diabetics. Strategies for treatment are sorely needed and will require a better understanding of disease pathogenesis.
November 25, 2013 Desktop Wallpaper Calendars for December 2013
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November 22, 2013 Register now for our December Webinar on Mouse Models of Cardiovascular Diseases
Webinar highlights several of the hundreds of mouse models that can advance your research in areas of atherosclerosis, metabolic syndrome, hypertension, coronary heart disease and other heart disorders.
November 20, 2013 IL-21 Cuts Both Ways in Lupus
IL-21 Is a Double-Edged Sword in the Systemic Lupus Erythematosus-like Disease of BXSB.Yaa Mice
November 12, 2013 An Alternative to the Yearly Flu Shot?
Vectored immunoprophylaxis offers complete protection against influenza in mice
November 11, 2013 Reawakened T cells Improve Chronic HIV Infection in Humanized NSG Mice
Blocking PD1 protein on cytotoxic T cell suppress viral load
October 29, 2013 Desktop Wallpaper Calendars for November 2013
Free downloadable image for your desktop
October 28, 2013 Genetic Control of Long-term Memory
A recent report in the journal Cell Reports (Roy et al. 2013) describes a novel function of Peroxisome Proliferator Activated Receptor alpha (Ppara). Ppara is known to control fatty acid catabolism in the liver, but these researchers used C57BL/6J (000664) wild-type and B6;129S4-Pparatm1Gonz/J (008154) knockout mice to elegantly demonstrate that Ppara gene expression in the hippocampus also controls long-term memory.
October 28, 2013 Stimulation of Cellular Regeneration to Treat MS
Researchers at The Scripps Research Institute report in a recent issue of Nature (Deshmukh et al. 2013) a therapeutic approach to stimulate remyelination in vivo using the myelin proteolipid protein (PLP)-induced experimental autoimmune encephalomyelitis (EAE) SJL/J (000686) mouse model of MS.
October 14, 2013 Statins Offer New Hope for Treating Rett Syndrome

An elegant genetic screen has uncovered an unexpected role for cholesterol metabolism in the development of Rett syndrome in mouse models. Inhibiting cholesterol metabolism with statin drugs extended lifespan and improved neurological symptoms in a model of the disease.

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