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June 10, 2014 Insulin Degrading Enzyme Inhibitor Modulates Glucose Tolerance and Uncovers Expanded Roles
An exciting new report in Nature (Maianti et al. 2014) describes the discovery of a new insulin-degrading enzyme (IDE) inhibitor that improves glucose tolerance in a model of pre-diabetes and identifies previously unknown roles for IDE in glucose homeostasis beyond insulin regulation.
June 10, 2014 Longevity Biomarkers Revealed from Inbred Mouse Strains
A recent article in Aging Cell demonstrates a new protocol to identify pro-longevity, anti-longevity or role switching biomarkers utilizing the aging study data published in the Mouse Phenome Database. Their protocol may provide insights beyond the scheme of biomarkers for long or short lifespan.
May 27, 2014 Hunting for the Cellular Targets in Huntington’s
A new publication in Nature Medicine (Wang et al. 2014) reports on the expression of mutant huntingtin protein (mHTT) in specific regions of the brain and defines the cellular targets for optimal therapeutic intervention. The authors used Cre-Lox technology to diminish mutant protein expression in cortical or striatal neurons or in both regions of the brain. Mice were analyzed for improvement in motor function, psychiatric-like behaviors, and neurodegeneration. Results indicate that both regions of the brain may need to be targeted to obtain optimal therapeutic intervention.
May 26, 2014 Searching for the Secret Ingredients of the Fountain of Youth
Two recent exciting articles in Science and Nature Medicine demonstrated that exposure to young blood in aged mice is capable of rejuvenating heart and muscle tissue and improving synaptic plasticity along with cognitive functions. These studies revealed two critical players in these processes which may represent potential therapeutic targets for age-related disorders.
May 14, 2014 Effects of Cage Density on Inbred Mice
A recent article by Morgan et al. investigated the effect of housing density in five different inbred strains. The researchers from The Jackson Laboratory found that increased housing density for mice has no adverse effects and may even result in less stress— indicating that mice can be housed at higher densities than currently recommended by the Guide for the Care and Use of Laboratory Animals.
May 13, 2014 Transcranial Amelioration of Inflammation and Cell Death after Brain Injury
Investigators at the NIH (Roth et al.) describe a novel traumatic brain injury mouse model and delivery route for small molecule therapeutics that uncovers a role for inflammation in meningeal cell death.
April 29, 2014 Precise Genetic Mapping in Diversity Outbred Mice Identifies a Novel Pain Gene
Identifying drugable target genes that modulate human disease is a vital step in the drug discovery process.  The Diversity Outbred mice are a powerful tool to more rapidly identify new target genes.
April 15, 2014 Using “Don’t Eat Me” as an “Eat Me” Signal to Treat Cancer
An exciting report provides preclinical data that a monoclonal antibody can block the binding of CD47 on cancer cells to SIPRα on macrophages, converting a  “don’t eat me”  signal to “eat me”. This innate immunomodulatory approach used NSG mice engrafted with a variety of different human tumor types to demonstrate elimination of tumors, increased survival of the host, and phagocytosis of metastasizing tumor cells.   
April 15, 2014 Improving Translational Research: Make Your Mouse Studies Work
An inconvenient truth about translational research is that the success rate in developing patient therapeutics is unacceptably low. A recent article provides guidelines and recommendations to make animal models to work better and calls for more investment and due diligence to characterize animal models to boost the ability of preclinical work to predict drug effects in humans.
April 15, 2014 Desktop Wallpaper Calendars for April/May 2014
Free downloadable image for your desktop
April 1, 2014 Nanomedicine-Based Statin Delivery Inhibits Atherosclerotic Plaque Development
Atherosclerosis is a progressive inflammatory disease affecting arterial blood vessels.   Recently published in Nature Communications, Duivenvoorden et al. describe a novel nanomedicine that significantly reduces plaque area and inflammation.
April 1, 2014 Humanized FcRn Mice: New Models for Evaluating Pharmacokinetics of Human Therapeutic Antibodies
New models of humanized mice that are designed for evaluating therapeutic mAbs are presented and reviewed in a recent publication in Methods (G. Proetzel and D.C. Roopenian 2014). This article provides compiling evidence supporting the invaluable role of humanized FcRn models as strong and viable alternatives to primate PK studies of humanized mAbs and Fc-based compounds.
March 18, 2014 Breast Cancer Metastasis—not just an individual, but a group effort
A new publication in Cell (Cheung et al. 2013) uncovers a subpopulation of cells in luminal breast tumors lead a multicellular “collective invasion” of surrounding tissue.
March 18, 2014 Spontaneous Hair Cell Regeneration in Neonatal Mouse Cochlea
In a recent report published in Development (Cox et al.) designed two genetic mouse models for hair cell ablation, and found spontaneous regeneration in the cochlea of neonatal mice.
March 5, 2014 Complimentary March Webinar Series:
Making the Most of Your Research Colony

Our complimentary March webinar focus on maximizing the productivity of your mouse breeding colonies by understanding mouse reproductive biology and minimizing naturally occurring genetic drift. We are also proud to present two new webinars focusing on Huntington's Disease and Advances in Genetic Research.

March 4, 2014 Improved Nanogel-Based Delivery System for Treating
Systemic Lupus Erythematosus in Mice

Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory disease of the connective tissues.  A nanogel-based delivery system for drug treatment is shown to more directly target immune cells responsible to the autoimmune disease and slow disease progression in mice.
February 18, 2014 Desktop Wallpaper Calendars for March/April 2014
Free downloadable image for your desktop
February 17, 2014 Protection from HIV using VIP in BLT NSG!
An intriguing new publication in Nature Medicine (Balazs et al. 2014) provides preclinical evidence supporting the use of Vectored Immunoprophylaxis (VIP) to prevent transmission of HIV.  BLT NSG mice with human mucosal immunity were infected with HIV intravaginally, establishing a model of human heterosexual transmission. Humanized mice pretreated with VIP produced blocking antibodies that prevented HIV infection despite multiple viral exposures through the vaginal mucosa.
February 17, 2014 Antibody Directed Against TNFRSF21 is Neuroprotective in the SOD1*G93A Model of ALS
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord.  In a recent study published in Cell Death and Disease (Huang et al. 2013), inhibition of TNFRSF21 leads to motor neuron survival and functional improvement in a transgenic mouse model of ALS.
February 13, 2014 Register Today for Our Complimentary, Information-Rich Webinars

Join us for our latest webinars as we share valuable information on the innovative approaches to preclinical research and discovery using NSG mice, practical considerations for the care and housing of immune deficient mic, maximizing the productivity of your mouse breeding colonies, and minimizing naturally occurring genetic drift. We are also proud to present two new webinars focusing on Huntington's Disease and Advances in Genetic Research.

February 4, 2014 Humanized Mouse Model of Muscular Dystrophy
A new publication in Human Molecular Genetics (Zhang et al. 2014) describes a new mouse model of human skeletal muscle xenoengraftment in NRG immunodeficient mice.  These researchers demonstrated long term functional engraftment of skeletal muscle from normal and affected patients with Facioscapulohumeral Muscular Dystrophy (FSHD).
February 3, 2014 Deficiency of the ER Stress Protein Herpud1 Suppresses Atherosclerosis in Apoe Knockout Mice
ER stress has been implicated in the inflammatory response and progression of atherosclerotic lesions. A recent publication in PLoS One (Shinozaki, S. et al. 2013) demonstrates that a deficiency in the ER Stress protein Herpud1 suppresses atherosclerosis without altering plasma lipid levels.
January 22, 2014 New strains for research involving knockout mouse project (KOMP) mutations
FLP and Cre transgenic strains are now available on the same genetic background as KOMP alleles
January 22, 2014 Mesenchymal Stem Cells enhance islet transplantation in diabetic humanized mice
A recent publication in Molecular Therapy (Wu, H. et al. 2013) reports that human Mesenchymal Stem Cells can help improve primary function of transplanted human insulin producing β cells in a humanized NSG mouse made hyperglycemic by treatment with STZ. The Mesenchymal Stem Cells were also shown to suppress immune reaction by human peripheral blood cells towards the engrafted β cells. These results bring patients another step closer to successful islet replacement therapy.
January 22, 2014 Don't Miss the February JAX WebinarsTM. Reguster Today for Our Complimentary, Information-Rich Webinars 
The February JAX WebinarTM series shares valuable information from the expert research staff at The Jackson Laboratory on selecting immune deficient mouse models, innovative approaches to preclinical research and discovery using NSG mice, and practical considerations for the care and housing of immune deficient mice.
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