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DateNews/announcement
December 5, 2013 What can “Wicked High Cholesterol” mice teach us about heart disease?
Mutagenesis screens identify new genes important for understanding atherosclerosis.
November 26, 2013 Photoreceptor Cells Stress and Inflame the Retina in Diabetic Retinopathy
Diabetic retinopathy is a secondary complication of diabetes that diminishes quality of life and impacts the majority of long-term diabetics. Strategies for treatment are sorely needed and will require a better understanding of disease pathogenesis.
November 25, 2013 Desktop Wallpaper Calendars for December 2013
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November 22, 2013 Register now for our December Webinar on Mouse Models of Cardiovascular Diseases
Webinar highlights several of the hundreds of mouse models that can advance your research in areas of atherosclerosis, metabolic syndrome, hypertension, coronary heart disease and other heart disorders.
November 20, 2013 IL-21 Cuts Both Ways in Lupus
IL-21 Is a Double-Edged Sword in the Systemic Lupus Erythematosus-like Disease of BXSB.Yaa Mice
November 12, 2013 An Alternative to the Yearly Flu Shot?
Vectored immunoprophylaxis offers complete protection against influenza in mice
November 11, 2013 Reawakened T cells Improve Chronic HIV Infection in Humanized NSG Mice
Blocking PD1 protein on cytotoxic T cell suppress viral load
October 29, 2013 Desktop Wallpaper Calendars for November 2013
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October 28, 2013 Genetic Control of Long-term Memory
A recent report in the journal Cell Reports (Roy et al. 2013) describes a novel function of Peroxisome Proliferator Activated Receptor alpha (Ppara). Ppara is known to control fatty acid catabolism in the liver, but these researchers used C57BL/6J (000664) wild-type and B6;129S4-Pparatm1Gonz/J (008154) knockout mice to elegantly demonstrate that Ppara gene expression in the hippocampus also controls long-term memory.
October 28, 2013 Stimulation of Cellular Regeneration to Treat MS
Researchers at The Scripps Research Institute report in a recent issue of Nature (Deshmukh et al. 2013) a therapeutic approach to stimulate remyelination in vivo using the myelin proteolipid protein (PLP)-induced experimental autoimmune encephalomyelitis (EAE) SJL/J (000686) mouse model of MS.
October 14, 2013 Statins Offer New Hope for Treating Rett Syndrome

An elegant genetic screen has uncovered an unexpected role for cholesterol metabolism in the development of Rett syndrome in mouse models. Inhibiting cholesterol metabolism with statin drugs extended lifespan and improved neurological symptoms in a model of the disease.

October 12, 2013 Register for the November 7th Webinar: Protect Your Research: Know Your B6 Mouse
The C57BL/6 inbred mouse is the most commonly used research strain. This webinar will cover areas including substrain differences; the significance of control selection; recently published papers highlighting the differences between substrains.
October 7, 2013 Register now for our November Webinars on Modeling Human Infectious Diseases in Mice
Webinars highlighting the challenges and innovations for studying viruses (HIV, Dengue, and Ebola), bacteria, and parasites that infect humans and how humanized NSG mice have revolutionized this field.
October 1, 2013 Desktop Wallpaper Calendars for October 2013
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September 30, 2013 First Mouse Model to Successfully Replicate Hepatitis C
Genetically humanized mice enable both infection and replication of Hepatitis C virus
September 27, 2013 Breaking the addiction to high-fat food
Excess dietary fat leads to dopamine deficiency and diminishes reward of lower calorie foods
September 17, 2013 Stem Cells Created In Vivo Have Greater Potential
Recent work has shown that iPS cells produced in vivo in mice represent a more primitive type of totipotent stem cell that is uniquely capable of producing the major embryonic and extraembryonic cell lineages.
September 16, 2013 A Dozen Facts You Didn’t Know About Cre-lox
Some underappreciated and overlooked aspects of this powerful genetic engineering tool
September 3, 2013 Relaxin muscle to treat diabetes
Treatment of obese, pre-diabetic, mice with relaxin hormone improves insulin resistance
September 3, 2013 Desktop Wallpaper Calendars for September 2013
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August 29, 2013 Bacteria are a Pain
Bacteria are capable of directly inducing pain in mouse sensory neurons, allowing suppression of the immune response
August 21, 2013 All Black 6 Mice Are Not Created Equal
New findings highlight differences in genetics and phenotypes between C57BL/6 and C57BL/6N
August 20, 2013 Sophisticated New Model for Ovarian Cancer Developed
Improved modeling of tumor microenvironment in NSG mice leads to a more clinically relevant model of ovarian cancer
August 14, 2013 Register now for our September Webinars on The Foundations of Mouse Research
Webinars on using mouse models effectively in research
August 7, 2013 Early Signs of Huntington's Disease Are Detectable in Mice
Early diagnosis in humans may facilitate therapeutic intervention
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