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DateNews/announcement
January 21, 2015 Desktop Wallpaper Calendars for February 2015
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January 20, 2015 Breast Cancer Stem Cell Self-Promotion Occurs through Extracellular Matrix Modification
A compelling 2015 study by Chang et al. demonstrates that a specialized population of breast cancer stem cells promotes its own “stemness” and influences its microenvironment through a TAZ transcriptional positive feedback loop. 
January 20, 2015 Curcumin Attenuates Western Diet-Induced Disease by Increasing Intestinal Barrier Function
An exciting new study in PLOS One (Ghosh, Bie, Wang, and Ghosh. 2014) demonstrates the potential for targeting intestinal barrier function as a therapeutic approach for metabolic diseases like atherosclerosis and Type 2 Diabetes  and identifies curcumin as a strong therapeutic candidate.
January 6, 2015 Pneumococcal bacteria can directly infect and damage the heart in mice: Implications for human heart disease.
A recent article by Brown et al. in PLoS Pathogens demonstrate that Streptococcus pneumonia, a common Gram-positive bacterium, directly damages myocardium and disrupts cardiac function, providing compelling evidence that direct infection of heart tissue by bacteria can contribution to heart disease.
January 6, 2015 Triagonist Peptide for Weight Loss and Glycemic Control
A new report in Nature Medicine (Finan et al. 2014) describes a synthetic peptide agonist capable of binding three different hormone receptors that are key regulators of metabolism.  The triagonist peptide reduced body weight, improved glycemic control, reversed hepatic steatosis, and maintained lean body mass in several rodent models of human type 2 diabetes.
January 6, 2015 Desktop Wallpaper Calendars for January 2015
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January 5, 2015 Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last
December 10, 2014 Safer Gene Therapy for Immuno-Oncology
An important advance in developing safer gene therapies for immune-mediated cancer treatments has been reported in Cancer Research (Gschweng et al. 2014).  The safety of gene delivery by viral vectors into human hematopoietic stem cells (HSCs) is a legitimate concern based on adverse events observed in early clinical trials. Gschweng et al. have addresses this issue by creating a vector engineered to co-deliver a suicide gene along with a therapeutic anti-tumor T cell receptor (TCR).
December 9, 2014 Essential airway stem cells for lung generation
An exciting article in Nature reveals a mechanism by which a population of distal airway stem cells contributes to lung regeneration following acute viral infection and lung injury.  The studies highlight the potential for stem-cell based therapeutic strategies for treating patients with acute and chronic lung disease.
November 24, 2014 In Vivo Optogenetic Modulation of Cerebellar Networks
A recent article in PLoS One demonstrates a new device to precisely control and simultaneously record from specific neuronal circuits and cell-types in vivo using optogenetic tools. 
November 24, 2014 Replacement of Embryo-derived Cardiac Macrophages with Age May Affect Heart Tissue Homeostasis
A recent study (Molawi et al., 2014) describes how resident, embryo-derived macrophages in the heart slowly lose their capacity for self-renewal, and are replaced gradually by less proliferative, monocyte-derived macrophages.   This transition is associated with decreased capacity to repair cardiac tissue, and might explain the increased prevalence of cardiac disease as we age.
November 10, 2014 Tumor-Stromal Cell Turnover in PDX Mice
Stromal cells found within epithelial tumors can have a significant impact on the growth, vascularization, invasiveness, and metastatic potential of the cancer.  These features make stromal cell populations potential therapeutic targets.  A new publication in the journal Digestive Diseases and Sciences (Maykel et al., 2014) demonstrates the importance of immunodeficient host mouse selection for efficient propagation of primary human tumors referred to as patient derived xenografts (PDX), maintenance of tumor microenvironment, and in establishing a platform for in vivo therapy testing.
October 28, 2014 Novel Inhibitor Targets Vascular and Cognitive Defects in AD Mice
A new study in Journal of Experimental Medicine (Ahn et al. 2014) describes a novel molecule that targets Aβ-fibrinogen interactions in the 5XFAD mouse model of Alzheimer’s disease.  The novel inhibitor, RU-505, demonstrates efficacy in improving cerebrovascular and cognitive deficits in this model.
October 28, 2014 Desktop Wallpaper Calendars for November/December 2014
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October 26, 2014 Intestinal cell modifications aid gut microbiota during infection, helps host
A recent article in Nature reveals an exciting mechanism by which a host can select beneficial micro-biota to improve its own fitness during systemic infection.  The studies provide novel insights into host-gut microbiota mutualistic relationships.
October 9, 2014 Cas9 Knock-in Mice for Efficient Genome Editing In Vivo and Ex Vivo
Two novel Cas9-expressing mouse models are described in a recent Cell publication from the laboratory of Dr. Feng Zhang at MIT.  The Cre-dependent LSL-Cas9 (024857) and constitutive Cas9 (024858) mice offer numerous and exciting possibilities for genome editing in vivo and ex vivo.
October 9, 2014 Complete Life Cycle of Malaria Parasite in Humanized DRAG Mice
A very import new advance towards the development of Malaria therapy has been reported in Malaria Journal (Wijayalath et al., 2014).  The work presented by Wijayalath et al. demonstrates, for the first time, a mouse model that enables all components of the malaria parasite life cycle. This new model supports human immune functions that will allow a greater understanding of the immunobiology of malaria, which in turn may allow for the development of new treatment strategies.
September 30, 2014 Humanized Mice for Tumor Antibody Production
An exciting publication in the journal mAbs (Wege et al. 2014) describes a new method for making human B cell-derived antibodies specific for novel antigens present on human cancer cells.  These researchers accomplished this in vivo by co-injecting human hematopoietic stem cells and human breast cancer cells into immunodeficient NSG mice.  The mice developed a human immune system, including antibodies in serum that were specific for antigens on the engrafted tumor cells.
September 30, 2014  Potential New Therapeutic Target for Treating Down Syndrome
A new study in PLoS One (Garcia-Cerro, S. et al. 2014) identifies a potential therapeutic target to ameliorate learning disabilities in Down syndrome (DS).  Normalization of Dyrk1a (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) gene dosage in B6EiCSN.BLiA-TS(1716)65Dn/J (Ts65Dn, 005252)rescues many, but not all, of the cognitive and neuromorphological phenotypes observed in trisomic (TS) mice.  Drug or genetic targeting of Dyrk1a, therefore, may be a novel therapeutic target to improve memory and learning for DS patients. 
September 16, 2014 Targeting Endothelin and Complement Pathways is Effective in Preventing Glaucoma in Mice
A recent article in Neurobiology of Disease revealed an exciting and robust therapeutic strategy to prevent glaucoma development in mice using combinatorial inhibition of both the endothelin system and the classical complement cascade. Their studies offer great potential to transform the treatment of glaucoma.
September 16, 2014 Inhibition of Obesity by Manipulation of Gut Microbiota
A new study in Journal of Clinical Investigation (Chen, et al. 2014) describes genetic engineering and therapeutic delivery of gut bacteria, which provide long-lasting inhibition of obesity and improved insulin response in both induced and polygenic mouse models of obesity.
September 3, 2014 Validated Therapeutic Target for ALS
A new publication in Science Translational Medicine (de Boer, A. S. et al. 2014) uncovers and validates a new mechanism of disease in Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease). These researchers show that microglia from ALS mice (B6SJL-Tg(SOD1*G93A)1Gur/J 002726) are toxic to normal human motor neurons in vitro. The researchers also found that blockage of signaling through the prostaglandin D receptor (Ptgdr, or DP1) could restore motor neuron survival and extend lifespan.  These findings suggest inhibiting the DPI receptor could be a viable therapeutic strategy in the future. 
September 3, 2014 MR Imaging for Monitoring Therapeutic Response in Live Mice
A new study in NeuroReport (Kim et al. 2014) describes a new non-invasive imaging technology for detection of amyloid plaques and monitoring of responses to drug treatments in mouse models of Alzheimer’s disease.
August 20, 2014 Desktop Wallpaper Calendars for September/October 2014
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August 19, 2014 Transgenic Parasites to Dissect Host-Pathogen Interactions During Toxoplasmosis
A new report in Infection and Immunity (Christian et al.  2014) describes a powerful new T. gondii cre-lox based fluorescent reporter system for tracking host-pathogen cell interactions which can provide new insights into how host cells respond in vivo to toxoplasmosis infection.
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