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DateNews/announcement
April 16, 2015 The Cancer Arms Race: Targeting Multiple Immune Pathways to Match Cancer Evolution
In a new, reverse translational study, a team of investigators from the University of Pennsylvania report that a three-pronged, combination therapy using radiation and two checkpoint inhibitors boosts T cell responses against metastatic melanoma.
April 14, 2015 Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last
March 31, 2015 Desktop Wallpaper Calendars for April 2015
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March 31, 2015 Enhancement of Antibody Production in Humanized Mice
A newly published approach to humanizing NSG mice demonstrates improved B cell development and IgG antibody production following immunization.  The new method addresses an important limitation in immune cell responses that develop in mice humanized using other protocols. The new technique improves follicular lymphoid structure development and splenic germinal center formation, which are necessary and critical for B cell maturation, immunoglobulin class switching, and the development of IgG-producing plasma cells.
March 31, 2015 Mecp2 Mutations Underlie Decreased Bone Mass in Rett Syndrome
Previously, the early-onset osteoporosis experienced by many Rett syndrome patients has been attributed to drug side effects or to patient behavior.  New research suggests that the same MECP2 mutations that underlie the neurological disorder also affect bone remodeling by osteoblasts.
March 17, 2015 Normalizing CD4+ T Cell Metabolism Reverses Systemic Lupus
An exciting new study in Science Translational Medicine(Yin et al. 2015) demonstrates that normalizing CD4+ T cell metabolism effectively reverses disease phenotypes in multiple mouse models of lupus, offering a novel therapeutic approach for treating this autoimmune disease in humans.
March 3, 2015 JAX® Mice Help Unravel Cannabinoid-induced Munchies
It has been commonly observed that smoking marijuana (Cannabis sativa) induces the "munchies". Indeed, the neural circuits in the hypothalamus that regulate satiety can be disrupted by cannabinoids derived from marijuana. New research published in Nature (Koch et al. 2015) reveals a key role for pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) in regulating food intake. Stimulating cannabinoid receptor 1 (CB1R) in the ARC activates POMC neurons and increases food consumption in fed mice. These findings describe an important new mechanism in controlling feeding behavior.
March 3, 2015 New NSGTM-variant model does not require irradiation for engraftment of HSCs
NSGTM mice (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ, Stock# 005557) have revolutionized human disease modeling by providing a platform with which to create new and valuable models to study human hematopoiesis, cancer, infectious and many other diseases. With their severely immunodeficient phenotype, NSGTM mice support higher levels of engraftment with many kinds of human cells and tissues than traditional immunocompromised host strains
February 18, 2015 Desktop Wallpaper Calendars for March 2015
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February 17, 2015 Time-Restricted Feeding:  The Latest Diet Craze?
An exciting study in Cell Metabolism (Chaix et al. 2014) illustrates the pleiotropic beneficial effects of time-restricted feeding on the development of obesity and related disease risk factors that does not rely on caloric restriction.
February 16, 2015 Cellular senescence: an unexpected advantage in wound healing
A 2014 publication demonstrates that senescent cells at a wound edge promote tissue repair.  The study uncovered secreted factors that may have clinical applications in improving wound closure and reducing scar tissue. 
February 4, 2015 Thirsty? Specific Neural Populations Drive the Instinct
The instinct to drink or stop drinking has been mapped to a distinct group of neurons in the mouse brain in a recent study (Oka et al., 2015). Optogenetic activation or inhibition of these neurons led water-satiated mice to drink or water-deprived mice to stop drinking, respectively. The identification of this control center in the brain points toward progress in mapping and understanding the specific circuits that regulate innate urges and motivations.
February 4, 2015 Inhibition of Diabetes Onset by an ROR Inverse Agonist
TH17 cells are a T cell subpopulation that plays a significant role in autoimmune diseases, including type 1 diabetes. Exciting new data published in Endocrinology (Solt et al. 2015) demonstrates that TH17 cell differentiation can be blocked in vivo by an RORα and RORγt antagonist. Treating NOD/ShiLtJ mice, a model of human type 1 diabetes, with the antagonist significantly diminished insulitis and prevented the onset and progression of diabetes.
January 21, 2015 Desktop Wallpaper Calendars for February 2015
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January 20, 2015 Breast Cancer Stem Cell Self-Promotion Occurs through Extracellular Matrix Modification
A compelling 2015 study by Chang et al. demonstrates that a specialized population of breast cancer stem cells promotes its own “stemness” and influences its microenvironment through a TAZ transcriptional positive feedback loop. 
January 20, 2015 Curcumin Attenuates Western Diet-Induced Disease by Increasing Intestinal Barrier Function
An exciting new study in PLOS One (Ghosh, Bie, Wang, and Ghosh. 2014) demonstrates the potential for targeting intestinal barrier function as a therapeutic approach for metabolic diseases like atherosclerosis and Type 2 Diabetes  and identifies curcumin as a strong therapeutic candidate.
January 6, 2015 Pneumococcal bacteria can directly infect and damage the heart in mice: Implications for human heart disease.
A recent article by Brown et al. in PLoS Pathogens demonstrate that Streptococcus pneumonia, a common Gram-positive bacterium, directly damages myocardium and disrupts cardiac function, providing compelling evidence that direct infection of heart tissue by bacteria can contribution to heart disease.
January 6, 2015 Triagonist Peptide for Weight Loss and Glycemic Control
A new report in Nature Medicine (Finan et al. 2014) describes a synthetic peptide agonist capable of binding three different hormone receptors that are key regulators of metabolism.  The triagonist peptide reduced body weight, improved glycemic control, reversed hepatic steatosis, and maintained lean body mass in several rodent models of human type 2 diabetes.
January 6, 2015 Desktop Wallpaper Calendars for January 2015
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December 10, 2014 Safer Gene Therapy for Immuno-Oncology
An important advance in developing safer gene therapies for immune-mediated cancer treatments has been reported in Cancer Research (Gschweng et al. 2014).  The safety of gene delivery by viral vectors into human hematopoietic stem cells (HSCs) is a legitimate concern based on adverse events observed in early clinical trials. Gschweng et al. have addresses this issue by creating a vector engineered to co-deliver a suicide gene along with a therapeutic anti-tumor T cell receptor (TCR).
December 9, 2014
November 24, 2014 In Vivo Optogenetic Modulation of Cerebellar Networks
A recent article in PLoS One demonstrates a new device to precisely control and simultaneously record from specific neuronal circuits and cell-types in vivo using optogenetic tools. 
November 24, 2014 Replacement of Embryo-derived Cardiac Macrophages with Age May Affect Heart Tissue Homeostasis
A recent study (Molawi et al., 2014) describes how resident, embryo-derived macrophages in the heart slowly lose their capacity for self-renewal, and are replaced gradually by less proliferative, monocyte-derived macrophages.   This transition is associated with decreased capacity to repair cardiac tissue, and might explain the increased prevalence of cardiac disease as we age.
November 10, 2014 Tumor-Stromal Cell Turnover in PDX Mice
Stromal cells found within epithelial tumors can have a significant impact on the growth, vascularization, invasiveness, and metastatic potential of the cancer.  These features make stromal cell populations potential therapeutic targets.  A new publication in the journal Digestive Diseases and Sciences (Maykel et al., 2014) demonstrates the importance of immunodeficient host mouse selection for efficient propagation of primary human tumors referred to as patient derived xenografts (PDX), maintenance of tumor microenvironment, and in establishing a platform for in vivo therapy testing.
October 28, 2014 Novel Inhibitor Targets Vascular and Cognitive Defects in AD Mice
A new study in Journal of Experimental Medicine (Ahn et al. 2014) describes a novel molecule that targets Aβ-fibrinogen interactions in the 5XFAD mouse model of Alzheimer’s disease.  The novel inhibitor, RU-505, demonstrates efficacy in improving cerebrovascular and cognitive deficits in this model.
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