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July 21, 2015 Cellular Architecture from the Outside-In
In a 2015 EMBO Journal study, the powerful interconnectedness between extracellular matrix homeostasis and internal cellular architecture is described.  Mice with a deficit in a remodeling collagenase exhibit profound cellular disorganization and induction of senescence, leading to dwarfism and premature death.  This study highlights the underlying mechanisms of diseases attributed to matrix metalloproteinase mutations, such as progeria, and may lead toward development of therapies for these patients.  
July 20, 2015 Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last
July 6, 2015 Not feeling the love? That makes scents.
Neuroscientists investigate fluctuations in female attraction to and sensory perception of male pheromones throughout the estrous cycle (Dey et al 2015).
July 6, 2015 Diversity Outbred Mice Identify Exposure Thresholds and Genetic Factors That Influence Benzene-Induced Genotoxicity
A 2015 study demonstrates that the J:DO mice display a reproducible response to benzene inhalation that more accurately reflects the range of responses observed in human populations. Further, genetic mapping linked variation in benzene-induced genotoxicity to two sulfotransferase candidate genes.
June 24, 2015 The XactMice You Need For a Tumor Microenvironment
A new publication in Oncogene (Morton et al., 2015) demonstrates the importance of human immune cells in maintaining the microenvironment of a patient derived xenograft (PDX).   The human immune cells infiltrate the tumor, stimulate lymphangiogenesis, and help maintain the original genetic expression profile of the PDX.  These observations highlight the complex interactions between tumors and the immune system and their importance in maintaining original tumor fidelity.  Humanized, tumor-bearing mice are clearly an important and relevant platform for studying human tumor biology, and will be an important tool for future preclinical efficacy testing.
June 24, 2015 Lymphatic Vessels Discovered within the Mouse Central Nervous System
A recent Nature study (Louveau et al. 2015) describes the discovery and characterization of lymphatic vessels in the dura of the central nervous system.  These long-elusive structures answer many neuroanatomical questions regarding how immune cells enter and exit the brain, and may improve our understanding of neural disease etiology and suggest novel treatment paradigms. 
June 24, 2015 Desktop Wallpaper Calendars for July 2015
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June 10, 2015 Sperm Counts: A Father’s Influence Is Far-Reaching
Researchers at Emory University School of Medicine demonstrate that environmental experience is transmitted through epigenetic modifications in the male germline and physically shapes neuroanatomy (Dias and Ressler 2014).
June 10, 2015 The ZEN of CRISPR/Cas9 Genome Editing

A recent publication in Genetics (Qin et al. 2015) by JAX researchers describes the use of electroporation to more efficiently deliver Cas9 mRNA, sgRNA and donor nucleotides to mouse embryos. The method allows more efficient generation of mice with a range of genetic alterations.

May 27, 2015 Desktop Wallpaper Calendars for June 2015
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May 27, 2015 Oxytocin Primes the Maternal Left Brain in Mice

New York University researchers have identified oxytocin-responsive neurons in the left auditory cortex that mediate maternal pup retrieval.

May 27, 2015 Generating New Self-Specific Treg Cells to Target Autoimmune Disorders

Deregulated, impaired Treg cells allow uncontrolled destruction of healthy tissues by cytotoxic T cells in many common autoimmune disorders.

May 13, 2015 Modeling Antibody-Induced Cytokine Storm in Hu-PBMC NSG™ Mice
Therapeutic antibodies (Abs) are being used clinically to treat cancer.  For many patients receiving these compounds, a potentially life- threatening condition called cytokine storm or cytokine release syndrome (CRS) can render these treatments unfeasible.
May 13, 2015 RBM3 Mediates Protective Effects of Cooling on Neurodegeneration
A new study in Nature (Peretti et al. 2015) demonstrates the protective effects of the cold-shock protein RBM3 on neurodegeneration in the 5XFAD mouse model of Alzheimer’s disease and a mouse model for prion disease.  The data suggests that modulating cold-shock protein pathways offers a potential and novel new therapeutic approach for preventing and treating neurodegenerative diseases.
April 29, 2015 Repurposing Viagra Reverses Peripheral Neuropathy in Diabetic Mice
A recent report in PLoS One (Wang et al. 2015) demonstrates that sildenafil (Viagra®) treatment significantly alleviates diabetic peripheral neuropathy and neurovascular dysfunction in mice with long-term diabetes.
April 29, 2015 Psychiatric Disorders in Offspring Linked to Asthmatic Mothers
A recent study (Schwartzer et al. 2015) in mice examining the developmental and behavioral differences between offspring born to asthmatic and non-asthmatic mothers draws an important link between inflammatory signaling in utero and its effect on neurological development.
April 29, 2015 Desktop Wallpaper Calendars for May 2015
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April 16, 2015 The Cancer Arms Race: Targeting Multiple Immune Pathways to Match Cancer Evolution
In a new, reverse translational study, a team of investigators from the University of Pennsylvania report that a three-pronged, combination therapy using radiation and two checkpoint inhibitors boosts T cell responses against metastatic melanoma.
March 31, 2015 Desktop Wallpaper Calendars for April 2015
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March 31, 2015 Enhancement of Antibody Production in Humanized Mice
A newly published approach to humanizing NSG mice demonstrates improved B cell development and IgG antibody production following immunization.  The new method addresses an important limitation in immune cell responses that develop in mice humanized using other protocols. The new technique improves follicular lymphoid structure development and splenic germinal center formation, which are necessary and critical for B cell maturation, immunoglobulin class switching, and the development of IgG-producing plasma cells.
March 31, 2015 Mecp2 Mutations Underlie Decreased Bone Mass in Rett Syndrome
Previously, the early-onset osteoporosis experienced by many Rett syndrome patients has been attributed to drug side effects or to patient behavior.  New research suggests that the same MECP2 mutations that underlie the neurological disorder also affect bone remodeling by osteoblasts.
March 17, 2015 Normalizing CD4+ T Cell Metabolism Reverses Systemic Lupus
An exciting new study in Science Translational Medicine(Yin et al. 2015) demonstrates that normalizing CD4+ T cell metabolism effectively reverses disease phenotypes in multiple mouse models of lupus, offering a novel therapeutic approach for treating this autoimmune disease in humans.
March 3, 2015 JAX® Mice Help Unravel Cannabinoid-induced Munchies
It has been commonly observed that smoking marijuana (Cannabis sativa) induces the "munchies". Indeed, the neural circuits in the hypothalamus that regulate satiety can be disrupted by cannabinoids derived from marijuana. New research published in Nature (Koch et al. 2015) reveals a key role for pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) in regulating food intake. Stimulating cannabinoid receptor 1 (CB1R) in the ARC activates POMC neurons and increases food consumption in fed mice. These findings describe an important new mechanism in controlling feeding behavior.
March 3, 2015 New NSGTM-variant model does not require irradiation for engraftment of HSCs
NSGTM mice (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ, Stock# 005557) have revolutionized human disease modeling by providing a platform with which to create new and valuable models to study human hematopoiesis, cancer, infectious and many other diseases. With their severely immunodeficient phenotype, NSGTM mice support higher levels of engraftment with many kinds of human cells and tissues than traditional immunocompromised host strains
February 18, 2015 Desktop Wallpaper Calendars for March 2015
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