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DateNews/announcement
March 3, 2015 JAX® Mice Help Unravel Cannabinoid-induced Munchies
It has been commonly observed that smoking marijuana (Cannabis sativa) induces the "munchies". Indeed, the neural circuits in the hypothalamus that regulate satiety can be disrupted by cannabinoids derived from marijuana. New research published in Nature (Koch et al. 2015) reveals a key role for pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) in regulating food intake. Stimulating cannabinoid receptor 1 (CB1R) in the ARC activates POMC neurons and increases food consumption in fed mice. These findings describe an important new mechanism in controlling feeding behavior.
March 3, 2015 New NSGTM-variant model does not require irradiation for engraftment of HSCs
NSGTM mice (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ, Stock# 005557) have revolutionized human disease modeling by providing a platform with which to create new and valuable models to study human hematopoiesis, cancer, infectious and many other diseases. With their severely immunodeficient phenotype, NSGTM mice support higher levels of engraftment with many kinds of human cells and tissues than traditional immunocompromised host strains
February 23, 2015 Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last
February 18, 2015 Desktop Wallpaper Calendars for March 2015
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February 17, 2015 Time-Restricted Feeding:  The Latest Diet Craze?
An exciting study in Cell Metabolism (Chaix et al. 2014) illustrates the pleiotropic beneficial effects of time-restricted feeding on the development of obesity and related disease risk factors that does not rely on caloric restriction.
February 16, 2015 Cellular senescence: an unexpected advantage in wound healing
A 2014 publication demonstrates that senescent cells at a wound edge promote tissue repair.  The study uncovered secreted factors that may have clinical applications in improving wound closure and reducing scar tissue. 
February 4, 2015 Thirsty? Specific Neural Populations Drive the Instinct
The instinct to drink or stop drinking has been mapped to a distinct group of neurons in the mouse brain in a recent study (Oka et al., 2015). Optogenetic activation or inhibition of these neurons led water-satiated mice to drink or water-deprived mice to stop drinking, respectively. The identification of this control center in the brain points toward progress in mapping and understanding the specific circuits that regulate innate urges and motivations.
February 4, 2015 Inhibition of Diabetes Onset by an ROR Inverse Agonist
TH17 cells are a T cell subpopulation that plays a significant role in autoimmune diseases, including type 1 diabetes. Exciting new data published in Endocrinology (Solt et al. 2015) demonstrates that TH17 cell differentiation can be blocked in vivo by an RORα and RORγt antagonist. Treating NOD/ShiLtJ mice, a model of human type 1 diabetes, with the antagonist significantly diminished insulitis and prevented the onset and progression of diabetes.
January 21, 2015 Desktop Wallpaper Calendars for February 2015
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January 20, 2015 Breast Cancer Stem Cell Self-Promotion Occurs through Extracellular Matrix Modification
A compelling 2015 study by Chang et al. demonstrates that a specialized population of breast cancer stem cells promotes its own “stemness” and influences its microenvironment through a TAZ transcriptional positive feedback loop. 
January 20, 2015 Curcumin Attenuates Western Diet-Induced Disease by Increasing Intestinal Barrier Function
An exciting new study in PLOS One (Ghosh, Bie, Wang, and Ghosh. 2014) demonstrates the potential for targeting intestinal barrier function as a therapeutic approach for metabolic diseases like atherosclerosis and Type 2 Diabetes  and identifies curcumin as a strong therapeutic candidate.
January 6, 2015 Pneumococcal bacteria can directly infect and damage the heart in mice: Implications for human heart disease.
A recent article by Brown et al. in PLoS Pathogens demonstrate that Streptococcus pneumonia, a common Gram-positive bacterium, directly damages myocardium and disrupts cardiac function, providing compelling evidence that direct infection of heart tissue by bacteria can contribution to heart disease.
January 6, 2015 Triagonist Peptide for Weight Loss and Glycemic Control
A new report in Nature Medicine (Finan et al. 2014) describes a synthetic peptide agonist capable of binding three different hormone receptors that are key regulators of metabolism.  The triagonist peptide reduced body weight, improved glycemic control, reversed hepatic steatosis, and maintained lean body mass in several rodent models of human type 2 diabetes.
January 6, 2015 Desktop Wallpaper Calendars for January 2015
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December 10, 2014 Safer Gene Therapy for Immuno-Oncology
An important advance in developing safer gene therapies for immune-mediated cancer treatments has been reported in Cancer Research (Gschweng et al. 2014).  The safety of gene delivery by viral vectors into human hematopoietic stem cells (HSCs) is a legitimate concern based on adverse events observed in early clinical trials. Gschweng et al. have addresses this issue by creating a vector engineered to co-deliver a suicide gene along with a therapeutic anti-tumor T cell receptor (TCR).
December 9, 2014 Essential airway stem cells for lung generation
An exciting article in Nature reveals a mechanism by which a population of distal airway stem cells contributes to lung regeneration following acute viral infection and lung injury.  The studies highlight the potential for stem-cell based therapeutic strategies for treating patients with acute and chronic lung disease.
November 24, 2014 In Vivo Optogenetic Modulation of Cerebellar Networks
A recent article in PLoS One demonstrates a new device to precisely control and simultaneously record from specific neuronal circuits and cell-types in vivo using optogenetic tools. 
November 24, 2014 Replacement of Embryo-derived Cardiac Macrophages with Age May Affect Heart Tissue Homeostasis
A recent study (Molawi et al., 2014) describes how resident, embryo-derived macrophages in the heart slowly lose their capacity for self-renewal, and are replaced gradually by less proliferative, monocyte-derived macrophages.   This transition is associated with decreased capacity to repair cardiac tissue, and might explain the increased prevalence of cardiac disease as we age.
November 10, 2014 Tumor-Stromal Cell Turnover in PDX Mice
Stromal cells found within epithelial tumors can have a significant impact on the growth, vascularization, invasiveness, and metastatic potential of the cancer.  These features make stromal cell populations potential therapeutic targets.  A new publication in the journal Digestive Diseases and Sciences (Maykel et al., 2014) demonstrates the importance of immunodeficient host mouse selection for efficient propagation of primary human tumors referred to as patient derived xenografts (PDX), maintenance of tumor microenvironment, and in establishing a platform for in vivo therapy testing.
October 28, 2014 Novel Inhibitor Targets Vascular and Cognitive Defects in AD Mice
A new study in Journal of Experimental Medicine (Ahn et al. 2014) describes a novel molecule that targets Aβ-fibrinogen interactions in the 5XFAD mouse model of Alzheimer’s disease.  The novel inhibitor, RU-505, demonstrates efficacy in improving cerebrovascular and cognitive deficits in this model.
October 28, 2014 Desktop Wallpaper Calendars for November/December 2014
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October 26, 2014 Intestinal cell modifications aid gut microbiota during infection, helps host
A recent article in Nature reveals an exciting mechanism by which a host can select beneficial micro-biota to improve its own fitness during systemic infection.  The studies provide novel insights into host-gut microbiota mutualistic relationships.
October 9, 2014 Cas9 Knock-in Mice for Efficient Genome Editing In Vivo and Ex Vivo
Two novel Cas9-expressing mouse models are described in a recent Cell publication from the laboratory of Dr. Feng Zhang at MIT.  The Cre-dependent LSL-Cas9 (024857) and constitutive Cas9 (024858) mice offer numerous and exciting possibilities for genome editing in vivo and ex vivo.
October 9, 2014 Complete Life Cycle of Malaria Parasite in Humanized DRAG Mice
A very import new advance towards the development of Malaria therapy has been reported in Malaria Journal (Wijayalath et al., 2014).  The work presented by Wijayalath et al. demonstrates, for the first time, a mouse model that enables all components of the malaria parasite life cycle. This new model supports human immune functions that will allow a greater understanding of the immunobiology of malaria, which in turn may allow for the development of new treatment strategies.
September 30, 2014 Humanized Mice for Tumor Antibody Production
An exciting publication in the journal mAbs (Wege et al. 2014) describes a new method for making human B cell-derived antibodies specific for novel antigens present on human cancer cells.  These researchers accomplished this in vivo by co-injecting human hematopoietic stem cells and human breast cancer cells into immunodeficient NSG mice.  The mice developed a human immune system, including antibodies in serum that were specific for antigens on the engrafted tumor cells.
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