Asthma
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| Scroll down for relevant In Vivo Services, pathway genes, JAX® Mice strains and references. Enlarge diagram |
Asthma compound evaluation services
Asthma is a chronic respiratory disease characterized by bronchial inflammation and airway hyperresponsiveness. JAX® In Vivo Services offers ovalbumin-sensitized mice to evaluate novel therapies for human allergic asthma.
Asthma compound testing service
Both cryopreserved and live Repository strains can be quickly and efficiently expanded to deliver cohorts directly into your discovery program. With JAX® Dedicated Supply Service and JAX® Speed Expansion Service you'll get the mice you need when you need them — fast.
Inducible models
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000651 | BALB/cJ | inducible (OVA) | Beigelman et al. 2009 |
JAX® Mice for asthma research
| Gene | Gene/protein function and details | Reference |
|---|---|---|
| Ccl2, chemokine (C-C motif) ligand 2 | Small cytokine belonging to the CC chemokine family; also known as monocyte chemotactic protein-1 (MCP-1). Recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. |
Chelbi et al. 2008 |
| Cd80, Cd80 antigen | Cd80 encodes B7-1, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly53 and CD28LG. |
van Rijt et al. 2004 |
| Cd86, Cd86 antigen | Cd86 encodes B7-2, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly58 and CD28LG2. |
van Rijt et al. 2004 |
| Ifng, interferon gamma | Cytokine critical for innate and adaptive immunity. Aberrant expression is associated with a number of autoinflammatory and autoimmune diseases. |
Cohn et al. 2001 |
| Il2ra, interleukin 2 receptor, alpha chain | The interleukin 2 receptor alpha (IL2RA), beta (IL2RB), and the common gamma chain (IL2RG) constitute the high-affinity IL2 receptor, expressed on immune cells, such as lymphocytes. Also known as Ly43 and CD25. |
Xia et al. 2006 |
| Il4, interleukin 4 | Cytokine that induces differentiation of naive helper T cells. A key regulator of adaptive immunity. |
Brusselle et al. 1994 |
| Il10, interleukin 10 | An anti-inflammatory cytokine primarily produced by monocytes, which has pleiotrophic effects in immunoregulation and inflammation. |
Koya et al. 2007 |
| Il12b, interleukin 12b | IL12 p40 subunit. Cytokine expressed by activated macrophages and important for Th1 cell development, regulation and memory. |
Meyts et al. 2006 |
| Myd88, myeloid differentiation primary response gene 88 | Adapter protein involved in Toll-like receptor and interleukin 1 receptor signaling pathways within the innate immune response. Activates the transcription factor NF-kappa-B. |
Yang et al. 20091 |
| Nos2, nitric oxide synthase 2, inducible | Encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. |
Trifilieff et al. 2000 |
| Pomc, pro-opiomelanocortin-alpha | Encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage. Gives rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. |
Raap et al. 2003 |
| Pparg, peroxisome proliferator activated receptor gamma | Member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors, which regulate transcription of various genes. Implicated in the pathology of numerous diseases. |
Honda et al. 2004 |
| Tlr2, toll-like receptor 2 | Surface receptor present on multiple immune cells. Binds diverse pathogenic substances and initiates innate immune responses. Also known as CD282 and Ly105. |
Buckland et al. 2008 |
| Tlr4, toll-like receptor 4 | Surface receptor for lipopolysaccharides from Gram-negative bacteria. Receptor engagement initiates innate immune response. |
Yang et al. 2009 |
| Tnf, tumor necrosis factor | Pleiotropic cytokine promoting inflammation, cell death, proliferation and other responses. Synthesized by many cell types. |
Hutchison et al. 2008 |
| Vdr, vitamin D receptor | Nuclear receptor capable of transactivating vitamin-D responsive genes. |
Wittke et al. 2007 |
| At this time there are no JAX® Mice strains available for the following symbols: Il13 and Nr3c1. | ||
