Inflammatory bowel disease
 |
| Scroll down for relevant In Vivo Services, pathway genes, JAX® Mice strains and references. Enlarge diagram |
Inflammatory bowel disease compound evaluation services
Inflammatory bowel disease (IBD) is a group of chronic, relapsing and remitting inflammatory conditions affecting the colon and distal small intestine. JAX® In Vivo Services offers several mouse models of IBD to evaluate novel therapies.
Both cryopreserved and live Repository strains can be quickly and efficiently expanded to deliver cohorts directly into your discovery program. With JAX® Dedicated Supply Service and JAX® Speed Expansion Service you'll get the mice you need when you need them — fast.
Inducible models
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000664 | C57BL/6J | inducible (DSS) | Mahler et al. 1998 |
| 000651 | BALB/cJ | inducible (TNBS) | Blumberg et al. 1999 |
| 001976 | NOD/ShiLtJ | inducible (DSS) | Mahler et al. 1998 |
| 004326 | C3Bir.129P2(B6)-Il10tm1Cgn/Lt | spontaneous (flora-dependent) | Kuhn et al. 1993 |
JAX® Mice for IBD research
| Gene | Gene/protein function and details | Reference |
|---|---|---|
| Cd4, Cd4 antigen | Glycoprotein expressed on the surface of helper T lymphocytes and other immune cells. CD4 functions to initiate or augment the early phase of T cell activation. |
Westendorf et al. 2005 |
| Cd40, CD40 antigen | A costimulatory protein found on antigen presenting cells and is required for their activation |
Danese et al. 2007 |
| Cd40lg, CD40 ligand | Protein expressed on both CD4+ and CD8+ T cells that aids in stimulating B cells in the immune response. |
Danese et al. 2007 |
| Cd80, Cd80 antigen | Cd80 encodes B7-1, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly53 and CD28LG. |
Eri et al. 2008 |
| Cd86, Cd86 antigen | Cd86 encodes B7-2, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly58 and CD28LG2. |
Ebert et al. 2005 |
| Fas, TNF receptor superfamily member 6 | TNF-receptor superfamily, death domain containing member. Plays a central role in the physiological regulation of programmed cell death and has been implicated in the pathogenesis of diseases of the immune system. Also known as CD95 and TNFR6. |
Yukawa et al. 2002 |
| Il2ra, interleukin 2 receptor, alpha chain | The interleukin 2 receptor alpha (IL2RA), beta (IL2RB), and the common gamma chain (IL2RG) constitute the high-affinity IL2 receptor, expressed on immune cells, such as lymphocytes. Also known as Ly43 and CD25. |
Holmén et al. 2007 |
| Il4, interleukin 4 | Cytokine that induces differentiation of naive helper T cells. A key regulator of adaptive immunity. |
Griga et al. 2000 |
| Il6, interleukin 6 | An interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. |
Atreya and Neurath. 2005 |
| Il7, interleukin 7 | Cytokine important for B and T cell development. Plays an essential role in lymphoid cell survival. |
Totsuka et al. 2007 |
| Il10, interleukin 10 | An anti-inflammatory cytokine primarily produced by monocytes, which has pleiotrophic effects in immunoregulation and inflammation. |
Akhiani et al. 2005 |
| Il12a, interleukin 12a | Cytokine which has a number of biological activities including T cell-independent induction of interferon (IFN)-gamma. Important for the differentiation of both Th1 and Th2 cells. |
Wada et al. 2007 |
| Il12b, interleukin 12b | IL12 p40 subunit. Cytokine expressed by activated macrophages and important for Th1 cell development, regulation and memory. |
Kugathasan et al. 2007 |
| Il1rn, interleukin 1 receptor antagonist | This protein inhibits the activity of interleukin 1 alpha (IL1A) and beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. |
Bioque et al. 1996 |
| Myd88, myeloid differentiation primary response gene 88 | Adapter protein involved in Toll-like receptor and interleukin 1 receptor signaling pathways within the innate immune response. Activates the transcription factor NF-kappa-B. |
Fukata et al. 2005. |
| Nos2, nitric oxide synthase 2, inducible | Encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. |
Porras et al. 2006 |
| Rela, v-rel reticuloendotheliosis viral oncogene homolog A | NF-kappa-B or p65 is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. |
Inoue et al. 2009 |
| Pomc, pro-opiomelanocortin-alpha | Encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage. Gives rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. |
Farhadi et al. 2005 |
| Pparg, peroxisome proliferator activated receptor gamma | Member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors, which regulate transcription of various genes. Implicated in the pathology of numerous diseases. |
Dubuquoy et al. 2003 |
| Ptgs2, prostaglandin-endoperoxide synthase 2 | Participates in synthesizing prostanoids involved in pain and inflammation. Also known as cyclooxygenase-2 (COX2). |
Singer et al. 1998 |
| Tlr2, toll-like receptor 2 | Surface receptor present on multiple immune cells. Binds diverse pathogenic substances and initiates innate immune responses. Also known as CD282 and Ly105. | Tanaka 2008 |
| Tlr4, toll-like receptor 4 | Surface receptor for lipopolysaccharides from Gram-negative bacteria. Receptor engagement initiates innate immune response. |
De Jager et al. 2007 |
| Tnf, tumor necrosis factor | Pleiotropic cytokine promoting inflammation, cell death, proliferation and other responses. Synthesized by many cell types. |
Ferguson et al. 2008 |
| Vdr, vitamin D receptor | Nuclear receptor capable of transactivating vitamin-D responsive genes. |
Froicu and Cantorna 2007 |
| At this time there are no JAX® Mice strains available for the following symbols: Il13 and Il23a. | ||
