Pathways to Discovery: Autoimmune Diseases
This comprehensive tool will save you the time and headache of determining molecular commonalities among different autoimmune diseases. You'll find actionable information on gene/pathway interactions between inflammatory bowel disease (IBD), rheumatoid arthritis, asthma, multiple sclerosis (MS) and psoriasis. The Pathways resource is also an invaluable time-saving device for non-autoimmune researchers as these same genes play important roles in cancer, Alzheimer's, atherosclerosis and obesity. In silico data mining and pathway software were used to integrate the interactions between diseases and bring the resource to life.
This new, comprehensive resource facilitates the identification of novel therapeutic targets, or the exploration of alternate therapeutic areas for existing targets, by providing the following:
- Schematics of gene/pathway associations common to IBD, arthritis, asthma, MS, and psoriasis
- Descriptions of JAX® In Vivo Pharmacology Services for autoimmune disease research
- Over 100 JAX® Mice strains linked to multiple autoimmune diseases
- Gene- and disease-specific references
Not an autoimmune disease researcher? Request a dedicated website on gene pathways for your research area.
- Inducible models for autoimmune diseases
- Helper T Cell Profile in Mouse Models of Autoimmune Disease
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| Common genetic pathway interactions exist between different autoimmune diseases. The Jackson Laboratory acknowledges Ingenuity Systems, Inc. for the biological pathway diagram and supporting content. Genes were included if they were associated with two or more disease areas. Enlarge diagram |
JAX® In Vivo Services for Autoimmune Disease Research
We provide fully customizable target validation and efficacy testing services with access to the world's largest collection of specialized mouse models of autoimmune disease. Newly available models and customized protocols supplement our standard services to provide an individualized experience. Our study directors and research scientists bring their expertise and collective knowledge of mouse physiology and genetics to work for you.
Inducible models for autoimmune diseases
In addition to the mutant JAX® Mice strains listed throughout this resource, the table below offers an overview of more than a dozen popular autoimmune disease-susceptible strains. These inducible mouse models recapitulate many aspects of the human disease and generally have a short latency to disease onset.
JAX® Mice distributes the best characterized, most genetically-stable mouse strains from both our East Coast, Bar Harbor, ME facility and our new, state-of-the-art West Coast, Sacramento, Calif. facility. The use of our common inbred strains supports the collection, preservation, and distribution of specialty mutant mouse models for the study of human diseases.
IBD
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000664 | C57BL/6J | inducible (DSS) | Mahler et al. 1998 |
| 000651 | BALB/cJ | inducible (TNBS) | Blumberg et al. 1999 |
| 001976 | NOD/ShiLtJ | inducible (DSS) | Mahler et al. 1998 |
| 004326 | C3Bir.129P2(B6)-Il10tm1Cgn/Lt | spontaneous (flora-dependent) | Kuhn et al. 1993 |
Rheumatoid arthritis
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000670 | DBA/1J | inducible (collagen) | Malfait et al. 2001 |
| 000651 | BALB/cJ | inducible (collagen-antibody) | Lange et al. 2005 |
| 000653 | BUB/BnJ | inducible (collagen) | Haqqi et al. 1995 |
Asthma
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000651 | BALB/cJ | inducible (OVA) | Beigelman et al. 2009 |
Multiple sclerosis
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000686 | SJL/J | inducible (proteolipid protein) | Duzhak et al. 2003 |
| 001026 | BALB/cByJ | inducible | Teuscher et al. 1987 |
| 100008 | NZBWF1/J | inducible (MBP) | Zamvil et al. 1994 |
| 000457 | B10.RIII-H2r H2-T18b/(71NS)SnJ | inducible (MBP) | Zhao et al. 1993 |
Psoriasis
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 001803 | CBySmn.CB17-Prkdcscid/J | inducible (adoptive T cell transfer) | Davenport et al. 2002 |
Helper T Cell Profile in Mouse Models of Autoimmune Disease
Helper T cells are lymphocytes capable of activating and directing a variety of immune cells to generate a successful immune response to infection. Three major subgroups of Th cells have been defined, Th1, Th2, and Th17, each with distinct cytokine products and biological functions*. Understanding the Th cell subgroup involved in autoimmune disease pathogenesis may lead to the development of novel treatments or identification of better models for efficacy testing current therapies for common autoimmune diseases. This resource lists the Th cell subset(s) linked to each specific mouse model, the particular cytokines secreted by each Th cell subgroup, and supporting references.
| Helper Cell Subset* | |||||
|---|---|---|---|---|---|
| Disease Area | Model | Mouse Strain | Th1 | Th2 | Th17 |
| Inflammatory Bowel Disease | DSS-induced (acute) | C57BL/6J (000664) or BALB/cJ (000651) | - | - | - |
| DSS-induced (chronic) | C57BL/6J (000664) |
- |
- | ||
| TNBS-induced | BALB/cJ (000651) | + Neurath et al. 1995 |
- | + Daniel et al. 2008 | |
| Adoptive CD4+CD45RBhi T cell transfer |
CBySmn.CB17-Prkdcscid/J (001803) | + Ogino et al. 2011 |
+ Kanai et al. 2006 |
+ Kulberg et al. 2006 | |
| Rheumatoid Arthritis | Collagen antibody-induced | BALB/cJ (000651) | - | - | - |
| Collagen-induced | DBA/1J (000670) DBA/1LacJ (001140) | + Malfait et al. 1998 |
- | + Lubberts et al. 2004 | |
| Asthma | OVA-induced | BALB/cJ (000651) | - | + Webb et al. 2000 |
+ Hellings et al. 2003 |
| Multiple Sclerosis | PLP-EAE MOG-EAE |
SJL/J (000686) C57BL/6J (000664) |
+ Mohindru et al. 2004 |
- | + O'Connor et al. 2008 |
| Psoriasis | CD4+CD45RBhi Adoptive T cell transfer | CBySmn.CB17-Prkdcscid/J (001803) | + Hong et al. 2011 |
- | + Ma et al. 2008 |
* Th1: Initiating Cytokine IL-12; Effector Cytokines INFγ, IL-2, TNFβ
Th2: Initiating Cytokine IL-4 Effector Cytokines IL-5, IL-4, IL-13, IL-6
Th17: Initiating Cytokine IL-21, TNFβ, IL-6 Effector Cytokines IL-17, IL-22, IL-26
