Multiple sclerosis
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| Scroll down for relevant In Vivo Services, pathway genes, JAX® Mice strains and references. Enlarge diagram |
Multiple sclerosis compound evaluation services
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. JAX® In Vivo Services offers experimental autoimmune encephalomyelitis (EAE) mice, a model of human MS, for investigation of new therapeutics.
Both cryopreserved and live Repository strains can be quickly and efficiently expanded to deliver cohorts directly into your discovery program. With JAX® Dedicated Supply Service and JAX® Speed Expansion Service you'll get the mice you need when you need them — fast.
Inducible models
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000686 | SJL/J | inducible (proteolipid protein) | Duzhak et al. 2003 |
| 001026 | BALB/cByJ | inducible | Teuscher et al. 1987 |
| 100008 | NZBWF1/J | inducible (MBP) | Zamvil et al. 1994 |
| 000457 | B10.RIII-H2r H2-T18b/(71NS)SnJ | inducible (MBP) | Zhao et al. 1993 |
JAX® Mice for multiple sclerosis research
| Gene | Gene/protein function and details | Reference |
|---|---|---|
| Ccl2, chemokine (C-C motif) ligand 2 | Small cytokine belonging to the CC chemokine family; also known as monocyte chemotactic protein-1 (MCP-1). Recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. |
Dogan et al. 2008 |
| Cd40, CD40 antigen | A costimulatory protein found on antigen presenting cells and is required for their activation |
Wiesemann et al. 2008 |
| Cd80, Cd80 antigen | Cd80 encodes B7-1, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly53 and CD28LG. |
Racke et al. 2000 |
| Cd86, Cd86 antigen | Cd86 encodes B7-2, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly58 and CD28LG2. |
Marckmann et al. 2004 |
| Ciita, class II transactivator | Positive regulator of Class II major histocompatibility complex (MHC) gene transcription, functioning through activation of the transcription factor RFX5. Considered the "master control factor", needed for expression of MHC Class II genes. |
Swanberg et al. 2005 |
| Fas, TNF receptor superfamily member 6 | TNF-receptor superfamily, death domain containing member. Plays a central role in the physiological regulation of programmed cell death and has been implicated in the pathogenesis of diseases of the immune system. Also known as CD95 and TNFR6. |
Lopatinskaya et al. 2006 |
| Ifng, interferon gamma | Cytokine critical for innate and adaptive immunity. Aberrant expression is associated with a number of autoinflammatory and autoimmune diseases. |
Schrijver et al. 2004 |
| Il2ra, interleukin 2 receptor, alpha chain | The interleukin 2 receptor alpha (IL2RA), beta (IL2RB), and the common gamma chain (IL2RG) constitute the high-affinity IL2 receptor, expressed on immune cells, such as lymphocytes. Also known as Ly43 and CD25. |
van Boxel-Dezaire et al. 2001 |
| Il4, interleukin 4 | Cytokine that induces differentiation of naive helper T cells. A key regulator of adaptive immunity. |
Ponomarev et al. 2007 |
| Il7, interleukin 7 | Cytokine important for B and T cell development. Plays an essential role in lymphoid cell survival. |
Kremlev et al. 2008 |
| Il10, interleukin 10 | An anti-inflammatory cytokine primarily produced by monocytes, which has pleiotrophic effects in immunoregulation and inflammation. | Dressel et al. 2006 |
| Il12a, interleukin 12a | Cytokine which has a number of biological activities including T cell-independent induction of interferon (IFN)-gamma. Important for the differentiation of both Th1 and Th2 cells. |
Gran et al. 2002 |
| Myd88, myeloid differentiation primary response gene 88 | Adapter protein involved in Toll-like receptor and interleukin 1 receptor signaling pathways within the innate immune response. Activates the transcription factor NF-kappa-B. |
Marta et al. 2009 |
| Nos2, nitric oxide synthase 2, inducible | Encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. |
Dogan et al. 2008 |
| Pomc, pro-opiomelanocortin-alpha | Encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage. Gives rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. |
Then Bergh et al. 1999 |
| Pparg, peroxisome proliferator activated receptor gamma | Member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors, which regulate transcription of various genes. Implicated in the pathology of numerous diseases. |
Aktas et al. 2007 |
| Ptgs2, prostaglandin-endoperoxide synthase 2 | Participates in synthesizing prostanoids involved in pain and inflammation. Also known as cyclooxygenase-2 (COX2). |
Rose et al. 2004 |
| Tlr2, toll-like receptor 2 | Surface receptor present on multiple immune cells. Binds diverse pathogenic substances and initiates innate immune responses. Also known as CD282 and Ly105. |
Buckland et al. 2008 |
| Tlr4, toll-like receptor 4 | Surface receptor for lipopolysaccharides from Gram-negative bacteria. Receptor engagement initiates innate immune response. |
Marta et al. 2008 |
| Tnf, tumor necrosis factor | Pleiotropic cytokine promoting inflammation, cell death, proliferation and other responses. Synthesized by many cell types. |
Dogan et al. 2008 |
| Vdr, vitamin D receptor | Nuclear receptor capable of transactivating vitamin-D responsive genes. |
Correale et al. 2009 |
| At this time there are no JAX® Mice strains available for the following symbols: H2-Eb1 and Nr3c1. | ||
