Psoriasis
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| Scroll down for relevant In Vivo Services, pathway genes, JAX® Mice strains and references. Enlarge diagram |
Psoriasis compound evaluation services (.pdf)
Psoriasis is a complex, chronic, inflammatory skin disease. JAX® In Vivo Services provides T cell adoptive transfer-induced models of psoriasis and IBD for compound efficacy testing.
Psoriasis compound testing service (.pdf)
Both cryopreserved and live Repository strains can be quickly and efficiently expanded to deliver cohorts directly into your discovery program. With JAX® Dedicated Supply Service and JAX® Speed Expansion Service you'll get the mice you need when you need them — fast.
Inducible models
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 001803 | CBySmn.CB17-Prkdcscid/J | inducible (adoptive T cell transfer) | Davenport et al. 2002 |
JAX® Mice for psoriasis research
| Gene | Gene/protein function and details | Reference |
|---|---|---|
| Cd4, Cd4 antigen | Glycoprotein expressed on the surface of helper T lymphocytes and other immune cells. CD4 functions to initiate or augment the early phase of T cell activation. |
Watabe et al. 2007 |
| Cd80, Cd80 antigen | Cd80 encodes B7-1, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly53 and CD28LG. |
Gottlieb et al. 2002 |
| Cd86, Cd86 antigen | Cd86 encodes B7-2, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly58 and CD28LG2. |
Abrams et al. 2000 |
| Fas, TNF receptor superfamily member 6 | TNF-receptor superfamily, death domain containing member. Plays a central role in the physiological regulation of programmed cell death and has been implicated in the pathogenesis of diseases of the immune system. Also known as CD95 and TNFR6. |
Gilhar et al. 2006 |
| Ifng, interferon gamma | Cytokine critical for innate and adaptive immunity. Aberrant expression is associated with a number of autoinflammatory and autoimmune diseases. |
Bockelmann et al. 2005 |
| Il2ra, interleukin 2 receptor, alpha chain | The interleukin 2 receptor alpha (IL2RA), beta (IL2RB), and the common gamma chain (IL2RG) constitute the high-affinity IL2 receptor, expressed on immune cells, such as lymphocytes. Also known as Ly43 and CD25. |
Krueger et al. 2000 |
| Il4, interleukin 4 | Cytokine that induces differentiation of naive helper T cells. A key regulator of adaptive immunity. |
Ghoreschi et al. 2003 |
| Il10, interleukin 10 | An anti-inflammatory cytokine primarily produced by monocytes, which has pleiotrophic effects in immunoregulation and inflammation. |
Asadullah et al. 2004 |
| Il12a, interleukin 12a | Cytokine which has a number of biological activities including T cell-independent induction of interferon (IFN)-gamma. Important for the differentiation of both Th1 and Th2 cells. |
Cheng et al. 2001 |
| Il12b, interleukin 12b | IL12 p40 subunit. Cytokine expressed by activated macrophages and important for Th1 cell development, regulation and memory. |
Nair et al. 2008 |
| Rela, v-rel reticuloendotheliosis viral oncogene homolog A | NF-kappa-B or p65 is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. |
Nair et al. 2009 |
| Pomc, pro-opiomelanocortin-alpha | Encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage. Gives rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. |
Karanikas et al. 2007 |
| Pparg, peroxisome proliferator activated receptor gamma | Member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors, which regulate transcription of various genes. Implicated in the pathology of numerous diseases. |
Kuenzli and Saurat. 2003 |
| Ptgs2, prostaglandin-endoperoxide synthase 2 | Participates in synthesizing prostanoids involved in pain and inflammation. Also known as cyclooxygenase-2 (COX2). |
Koczan et al. 2005 |
| Tnf, tumor necrosis factor | Pleiotropic cytokine promoting inflammation, cell death, proliferation and other responses. Synthesized by many cell types. |
Schottelius et al. 2004 |
| Vdr, vitamin D receptor | Nuclear receptor capable of transactivating vitamin-D responsive genes. |
Kong et al. 2006 |
| At this time there are no JAX® Mice strains available for the following symbols: H2-Eb1 and Il23a. | ||
