Rheumatoid arthritis
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| Scroll down for relevant In Vivo Services, pathway genes, JAX® Mice strains and references. Enlarge diagram |
Rheumatoid arthritis compound evaluation services
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that principally attacks the joints. JAX® In Vivo Services can model RA in mice for compound efficacy testing.
Both cryopreserved and live Repository strains can be quickly and efficiently expanded to deliver cohorts directly into your discovery program. With JAX® Dedicated Supply Service and JAX® Speed Expansion Service you'll get the mice you need when you need them — fast.
Inducible models
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000670 | DBA/1J | inducible (collagen) | Malfait et al. 2001 |
| 000651 | BALB/cJ | inducible (collagen-antibody) | Lange et al. 2005 |
| 000653 | BUB/BnJ | inducible (collagen) | Haqqi et al. 1995 |
JAX® Mice for rheumatoid arthritis research
| Gene | Gene/protein function and details | Reference |
|---|---|---|
| Ccl2, chemokine (C-C motif) ligand 2 | Small cytokine belonging to the CC chemokine family; also known as monocyte chemotactic protein-1 (MCP-1). Recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. |
Okamoto et al. 2008 |
| Cd4, Cd4 antigen | Glycoprotein expressed on the surface of helper T lymphocytes and other immune cells. CD4 functions to initiate or augment the early phase of T cell activation. |
Hirota et al. 2007 |
| Cd40, CD40 antigen | A costimulatory protein found on antigen presenting cells and is required for their activation |
van der Linden et al. 2009 |
| Cd40lg, CD40 ligand | Protein expressed on both CD4+ and CD8+ T cells that aids in stimulating B cells in the immune response. |
Lee et al. 2006 |
| Cd80, Cd80 antigen | Cd80 encodes B7-1, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly53 and CD28LG. |
Buch et al. 2008 |
| Cd86, Cd86 antigen | Cd86 encodes B7-2, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly58 and CD28LG2. |
Lagana et al. 2009 |
| Ciita, class II transactivator | Positive regulator of Class II major histocompatibility complex (MHC) gene transcription, functioning through activation of the transcription factor RFX5. Considered the "master control factor", needed for expression of MHC Class II genes. |
Swanberg et al. 2005 |
| Ifng, interferon gamma | Cytokine critical for innate and adaptive immunity. Aberrant expression is associated with a number of autoinflammatory and autoimmune diseases. |
Sattler et al. 2009 |
| Il2ra, interleukin 2 receptor, alpha chain | The interleukin 2 receptor alpha (IL2RA), beta (IL2RB), and the common gamma chain (IL2RG) constitute the high-affinity IL2 receptor, expressed on immune cells, such as lymphocytes. Also known as Ly43 and CD25. |
van Amelsfort et al. 2007 |
| Il4, interleukin 4 | Cytokine that induces differentiation of naive helper T cells. A key regulator of adaptive immunity. |
Finnegan et al. 2002 |
| Il6, interleukin 6 | An interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. |
Brennan and McInnes. 2008 |
| Il7, interleukin 7 | Cytokine important for B and T cell development. Plays an essential role in lymphoid cell survival. |
Churchman and Ponchel. 2008 |
| Il10, interleukin 10 | An anti-inflammatory cytokine primarily produced by monocytes, which has pleiotrophic effects in immunoregulation and inflammation. |
Antoniv and Ivashkiv. 2006 |
| Il12a, interleukin 12a | Cytokine which has a number of biological activities including T cell-independent induction of interferon (IFN)-gamma. Important for the differentiation of both Th1 and Th2 cells. |
Wada et al. 2007 |
| Il12b, interleukin 12b | IL12 p40 subunit. Cytokine expressed by activated macrophages and important for Th1 cell development, regulation and memory. |
Wada et al. 2007 |
| Il1rn, interleukin 1 receptor antagonist | This protein inhibits the activity of interleukin 1 alpha (IL1A) and beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. |
Ljung et al. 2007 |
| Myd88, myeloid differentiation primary response gene 88 | Adapter protein involved in Toll-like receptor and interleukin 1 receptor signaling pathways within the innate immune response. Activates the transcription factor NF-kappa-B. |
Sacre et al. 2007 |
| Pomc, pro-opiomelanocortin-alpha | Encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage. Gives rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. |
Slominski et al 1993 |
| Pparg, peroxisome proliferator activated receptor gamma | Member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors, which regulate transcription of various genes. Implicated in the pathology of numerous diseases. |
Okamoto et al. 2005 |
| Ptgs2, prostaglandin-endoperoxide synthase 2 | Participates in synthesizing prostanoids involved in pain and inflammation. Also known as cyclooxygenase-2 (COX2). |
Siegle et al. 1998 |
| Tlr2, toll-like receptor 2 | Surface receptor present on multiple immune cells. Binds diverse pathogenic substances and initiates innate immune responses. Also known as CD282 and Ly105. |
Huang et al. 2009 |
| Tlr4, toll-like receptor 4 | Surface receptor for lipopolysaccharides from Gram-negative bacteria. Receptor engagement initiates innate immune response. |
Abdollahi-Roodsaz et al. 2007 |
| Tnf, tumor necrosis factor | Pleiotropic cytokine promoting inflammation, cell death, proliferation and other responses. Synthesized by many cell types. |
Brennan and McInnes. 2008 |
| Vdr, vitamin D receptor | Nuclear receptor capable of transactivating vitamin-D responsive genes. |
Cutolo et al. 2007 |
| At this time there are no JAX® Mice strains available for the following symbols: Il13 and H2-Eb1 | ||
