JAX® Alopecia Areata Model

The first reliable, commercially available mouse model for alopecia areata.


Key benefits

  • JAX-developed technique (engraftment of diseased skin from an older mouse onto younger recipients) considerably accelerates onset of alopecia areata (AA) in C3H/HeJ (000659) mice
  • Polygenic and human-like AA
  • Highly trained staff with expertise in a variety of skin disorder models
  • Proximity of efficacy testing laboratory to AA mouse holding area minimizes transfer-induced stress
  • Supported by the National Alopecia Areata Foundation

Capabilities

Pricing

  • Determined by quotation

Image for figure 1 caption below.
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Figure 1. Oblique skin sections (A & B) showing an incursion of mononuclear cells (primarily CD4+ and CD8+ T lymphocytes) in and around anagen stage (actively growing) hair follicles. At greater magnification, these inflammatory cells can be seen between follicles and within the root sheaths. Longitudinal skin sections (C & D) confirm this condition which results in follicular dystrophy. Hair fibers produced by these follicles are structurally abnormal and break at the skin's surface.


Ordering information

Representatives are available
Monday - Friday:
8am-8pm ET (5am-5pm PT)

Toll free: 1-800-422-6423
International: +1-207-288-5845
Fax: +1-207-288-6150